Active Recombinant Human BMPR2 Protein, N-His-tagged

• Cat.No.: BMPR2-29H
• Product Overview: N-terminal 6His-tagged, recombinant fragment of human BMPR2 expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography.

Specification

• Description: Bone Morphogenetic Protein Receptor Type 2 (BMPR2) is a member of the bone morphogenetic protein receptor family of transmembrane serine/threonine kinases. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
• Source: Sf21
• Species: Human
• Tag: His
• Form: 1.85 mg/ml of enzyme in 40 mM Tris/HCl pH 7.5, 40 mM NaCl, 240 mM imidazole, 0.08 mM EGTA, 20% (v/v) glycerol. Frozen solution.
• Bio-activity: 8 U/mg, where one unit of BMPR2 activity is defined as 1 nmol phosphate incorporated into 0.33 mg/ml myelin basic protein (MBP) per minute at 30 centigrade with a final ATP concentration of 100 μM.
• Molecular Mass: 67 kDa
• Purity: 83% by SDS-PAGE and Coomassie blue staining.
• Applications: Drug Discovery & Development
• Storage: 1 year at -70 centigrade.
• Handling Advice: Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
• Use/Stability: On receipt of material store at -70 centigrade. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Gene Information

• Gene Name: BMPR2 bone morphogenetic protein receptor type 2 [ Homo sapiens (human) ]
• Official Symbol: BMPR2
• Synonyms: BMPR2; bone morphogenetic protein receptor type 2; BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II
• Gene ID: 659
• mRNA Refseq: NM_001204.7
• Protein Refseq: NP_001195.2
• MIM: 600799
• UniProt ID: Q13873

Reviews

11/20/2022

High-quality protein crystallography services, exceptional outcomes.

04/28/2022

Critical expertise in protein engineering, unmatched service quality.

07/29/2019

Swift and reliable protein sequencing, invaluable for our research.

Q&As

What role does BMPR2 play in the development and progression of pulmonary arterial hypertension (PAH)?

BMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.

What is the impact of BMPR2 mutations on hereditary hemorrhagic telangiectasia?

Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.

How do alterations in BMPR2 expression or signaling affect embryonic development and congenital anomalies?

Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.

What are the effects of BMPR2 dysregulation on renal function and kidney disease?

Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.

How does BMPR2 mediate the signaling pathways of bone morphogenetic proteins (BMPs) in bone formation and remodeling?

BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.

How does BMPR2 influence cardiovascular development and disease, particularly in heart valve formation?

BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.

How does BMPR2 contribute to the regulation of cell proliferation and apoptosis in various tissues?

BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.