BMPR1A

  • Official Full Name

    bone morphogenetic protein receptor, type IA

  • Overview

    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
  • Synonyms

    BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-prot;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • His
  • hFc
  • Fc Chimera
  • Fc|His
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|HIgG
  • His|SUMO
  • His|T7
  • human|IgG1|Fc
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMPR1A-553H Active Recombinant Human BMPR1A, Fc-tagged, Biotinylated Human Cell Fc
Human BMPR1A-26H Active Recombinant Human BMP Receptor Type IA, His-tagged His
Human BMPR1A-508H Active Recombinant Human BMPR1A, Fc Chimera Mammalian cells Fc Chimera
Human BMPR1A-28H Active Recombinant Human BMPR-1A, His-tagged Insect Cell His
Human BMPR1A-4130H Active Recombinant Human Bone Morphogenetic Protein Receptor, Type IA Human N/A
Human BMPR1A-545H Active Recombinant Human BMPR1A Protein, Fc Chimera Mammalian cells Fc
Human BMPR1A-554H Active Recombinant Human BMPR1A, Fc-tagged Human Cell Fc
Human BMPR1A-991H Recombinant Human Bone Morphogenetic Protein Receptor, Type IA, GST-tagged Sf9 Insect Cell GST
Human BMPR1A-160H Recombinant Human BMPR1A, His-tagged Insect Cell His
Human BMPR1A-771H Recombinant Human BMPR1A, Fc-His tagged Human Cell Fc/His
Human BMPR1A-867H Recombinant Human BMPR1A Protein, Fc/His-tagged HEK293 Fc/His
Human BMPR1A-889H Recombinant Human BMPR1A protein, His-tagged HEK293 His
Human BMPR1A-278H Recombinant Human BMPR1A Protein Wheat Germ N/A
Human BMPR1A-142H Recombinant Human BMPR1A protein, hIgG/His-tagged Insect Cell His/HIgG
Human BMPR1A-281H Recombinant Human BMPR1A Protein, GST-tagged Sf21 Insect Cell GST
Human BMPR1A-26752TH Recombinant Human BMPR1A Sf9 Insect Cell N/A
Human BMPR1A-279H Recombinant Human BMPR1A Protein, GST-tagged Wheat Germ GST
Human BMPR1A-2145HCL Recombinant Human BMPR1A cell lysate Human Cell N/A
Human BMPR1A-361H Recombinant Human BMPR1A Protein (177-532 aa), His-SUMO-tagged E.coli His/SUMO
Human BMPR1A-32H Active Recombinant Human BMPR1A Protein CHO cells N/A
Human BMPR1A-354H Recombinant Human BMPR1A protein, Fc-tagged HEK293 human/IgG1/Fc
Human BMPR1A-2706H Recombinant Human BMPR1A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BMPR1A-3748HF Recombinant Full Length Human BMPR1A Protein In Vitro Cell Free System
Human BMPR1A-2876H Recombinant Human BMPR1A protein, His-tagged E.coli His
Human BMPR1A-151H Recombinant Human BMPR1A Protein, His-tagged Human Cells His
Human BMPR1A-107H Recombinant Human BMPR1A Protein, His-tagged HEK293 His
Human BMPR1A-3749HF Recombinant Full Length Human BMPR1A Protein, GST-tagged In Vitro Cell Free System GST
Human BMPR1A-0787H Recombinant Human BMPR1A Protein (M1-I532), Tag Free Insect Cell No tag
Human BMPR1A-0683H Recombinant Human BMPR1A Protein (Gln24-Arg152), C-Fc and C-His tagged Mammalian cells C-Fc and C-His
Human BMPR1A-108H Recombinant Human BMPR1A Protein, Fc-tagged HEK293 Fc
Human BMPR1A-0684H Recombinant Human BMPR1A Protein (Gln24-Arg152), N-His tagged E.coli N-His
Human BMPR1A-169H-B Recombinant Human BMPR1A Protein Pre-coupled Magnetic Beads HEK293
Human BMPR1A-5114H Recombinant Human BMPR1A Protein (Met1-Arg152), C-His tagged Mammalian cells C-His
Human BMPR1A-0788H Recombinant Human BMPR1A Protein (M1-I532), GST tagged Insect Cell GST
Human BMPR1A-2932H Recombinant Human BMPR1A protein, His-tagged HEK293 His
Human BMPR1A-2678H Active Recombinant Human BMPR1A protein, hFc&His-tagged HEK293 hFc&His
Human BMPR1A-2931H Recombinant Human BMPR1A protein, Fc-tagged HEK293 Fc
Human BMPR1A-169H Recombinant Human BMPR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bmpr1a-623M Active Recombinant Mouse Bmpr1a Protein, Fc Chimera Mammalian cells Fc
Mouse Bmpr1a-247M Active Recombinant Mouse Bmpr1a protein, His&hFc-tagged HEK293 His&hFc
Mouse Bmpr1a-24M Active Recombinant Mouse Bmpr1a protein(Met1-Arg152), His-tagged HEK293 C-His
Mouse Bmpr1a-1709M Recombinant Mouse Bone Morphogenetic Protein Receptor, Type 1A Mammalian cells N/A
Mouse BMPR1A-2466MCL Recombinant Mouse BMPR1A cell lysate Human Cell N/A
Mouse Bmpr1a-10524M Recombinant Mouse Bmpr1a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bmpr1a-10524M-B Recombinant Mouse Bmpr1a Protein Pre-coupled Magnetic Beads HEK293
Mouse Bmpr1a-714M Recombinant Mouse Bmpr1a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Bmpr1a-576R Recombinant Rat Bmpr1a protein, His & T7-tagged E.coli His/T7
Rat BMPR1A-999R Recombinant Rat BMPR1A Protein Mammalian Cell His
Rat BMPR1A-657R Recombinant Rat BMPR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BMPR1A-657R-B Recombinant Rat BMPR1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey BMPR1A-1685R Recombinant Rhesus Monkey BMPR1A Protein HEK293 N/A
Rhesus monkey BMPR1A-1686R Recombinant Rhesus Monkey BMPR1A Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey BMPR1A-1687R Recombinant Rhesus Monkey BMPR1A Protein, hIgG4-tagged HEK293 hIgG4
Canine BMPR1A-1043C Active Recombinant Canine BMPR1A protein(Met1-Arg152), hFc-tagged HEK293 C-hFc
Homo sapiens (Human) RFL24140HF Recombinant Full Length Human Bone Morphogenetic Protein Receptor Type-1A(Bmpr1A) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL32762MF Recombinant Full Length Mouse Bone Morphogenetic Protein Receptor Type-1A(Bmpr1A) Protein, His-Tagged E.coli expression system His
Rhesus Macaque BMPR1A-547R Recombinant Rhesus monkey BMPR1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque BMPR1A-375R-B Recombinant Rhesus Macaque BMPR1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BMPR1A-375R Recombinant Rhesus Macaque BMPR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken BMPR1A-6909C Recombinant Chicken BMPR1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BMPR1A Related Gene Family
  • BMPR1A Related Research Area

BMPR1A involved in several pathways and played different roles in them. We selected most pathways BMPR1A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMPR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionNGFRB;INHBC;KITLGA;KDRL;CSF3;CCR5;CCL26;BMP7;ACVR2A
TGF-beta signaling pathwayROCK2B;TGFB2;INHBC;IFNG;BAMBIA;RHOAA;TGFBR2;EP300;SMAD9
Hippo signaling pathwaySERPINE1;YWHAG;GSK3B;FZD10;BMPR1A;WNT11;AJUBA;TGFB2;MPP5
Signaling pathways regulating pluripotency of stem cellsESX1;PIK3CB;FGFR1;WNT9B;JARID2;INHBC;SOX2;FGFR3;ID3

BMPR1A has several biochemical functions, for example, ATP binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMPR1A itself. We selected most functions BMPR1A had, and list some proteins which have the same functions with BMPR1A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP3K6;RUNX2;MAPK12A;EPHB4B;FASTK;NEK6;ADCY8;PFKFB2A;HSPE1
RNA polymerase II transcription factor activity, sequence-specific DNA bindingELF3;FOXD2;TFDP1;SOX14;ZSCAN1;SOX30;MEF2C;ERG;SPIC
SMAD bindingFKBP1A;STUB1;TGFBRAP1;PML;TOB1;USP15;SKOR1;TGFBR3;CREBBP
glycoprotein bindingRAB14;FOXRED2;FBXO17;SDC1;TFRC;BMPR1A;LACRT;FLNA;VLDLR
metal ion bindingNR1D2A;PRSS37;ZNF763;PM20D1.2;ZNF484;CYP2K19;ZBTB2;CACNA2D1;ZNF395A
protein bindingEXOSC5;GORAB;ARHGEF3;YRDC;ETV4;LYL1;CRX;TNFRSF11A;CACNG1
protein homodimerization activityDMRT3A;CARM1;JAM3;IL6ST;GIMAP7;ADAM10;CD200;CUBN;ENO3
protein serine/threonine kinase activitySYK;CDK14;EIF2AK4;PRKCBA;CAMKK1A;STK35;CSNK1E;MAP2K4;PIK3CA
receptor signaling protein serine/threonine kinase activitySLKA;BMPR2B;TGFB2;PANK1A;OXSR1B;ACVR1B;OXSR1A;SBK3;PAK2A
transmembrane receptor protein serine/threonine kinase activityBMPR1AA;TGFBR1B;ACVRL1;ALPK2;ACVR2A;ACVR1L;BMPR1BA;ACVR2AA;BMPR2B

BMPR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMPR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of BMPR1A.

BMP2; GDF5; BMP4; BMP2; BMP2; FSTL1; HSP90AB1

TGF
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What disease might abnormal BMPR1A levels suggest? 11/20/2022

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A? 10/12/2022

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed? 01/05/2022

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A? 01/03/2022

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment? 03/10/2020

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause? 01/21/2020

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.

Customer Reviews (3)

Write a review
Reviews
11/06/2021

    The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

    10/20/2021

      When experimenting with this protein, stable and repeatable results can be obtained.

      03/08/2021

        This product has strict quality control and complies with relevant industry standards.

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