bmpr1a
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  • Official Full Name
  • bone morphogenetic protein receptor, type IA
  • Background
  • The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
  • Synonyms
  • BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-prot
Cat.#:BMPR1A-2706HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR1A Protein, MYC/DDK-tagged
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Cat.#:BMPR1A-142HTag:hIgG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BMPR1A protein, hIgG/His-tagged
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Cat.#:BMPR1A-26752THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BMPR1A
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Cat.#:BMPR1A-26HTag:His
Source (Host):Species:Human
Product nameRecombinant Human BMP Receptor Type IA, His-tagged
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Cat.#:BMPR1A-278HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMPR1A Protein
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Cat.#:BMPR1A-279HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMPR1A Protein, GST-tagged
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Cat.#:BMPR1A-281HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BMPR1A Protein, GST-tagged
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Cat.#:BMPR1A-28HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human BMPR-1A, His-tagged
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Cat.#:BMPR1A-4130HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Bone Morphogenetic Protein Receptor, Type IA
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Cat.#:BMPR1A-508HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human BMPR1A, Fc Chimera
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Cat.#:BMPR1A-545HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human BMPR1A Protein, Fc Chimera
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Cat.#:BMPR1A-553HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human BMPR1A, Fc-tagged, Biotinylated
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Cat.#:BMPR1A-554HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human BMPR1A, Fc-tagged
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Cat.#:BMPR1A-771HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR1A, Fc-His tagged
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Cat.#:BMPR1A-867HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human BMPR1A Protein, Fc/His-tagged
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Cat.#:Bmpr1a-247MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Bmpr1a, Fc-His tagged
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Cat.#:Bmpr1a-24MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Bmpr1a, His tagged
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Cat.#:Bmpr1a-623MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Bmpr1a Protein, Fc Chimera
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Cat.#:Bmpr1a-576RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmpr1a protein, His & T7-tagged
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Cat.#:BMPR1A-999RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BMPR1A Protein
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Cat.#:BMPR1A-1685RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey BMPR1A Protein
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Cat.#:BMPR1A-1686RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey BMPR1A Protein, hIgG1-tagged
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Cat.#:BMPR1A-1687RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey BMPR1A Protein, hIgG4-tagged
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Cat.#:BMPR1A-547RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BMPR1A Protein, His-tagged
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Cat.#:BMPR1A-1043CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine BMPR1A Protein, Fc-tagged
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Cat.#:BMPR1A-6909CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BMPR1A
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Cat.#:BMPR1A-160HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human BMPR1A, His-tagged
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Cat.#:Bmpr1a-1709MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Bone Morphogenetic Protein Receptor, Type 1A
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Cat.#:BMPR1A-889HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Bone Morphogenetic Protein Receptor, Type IA, His-tagged
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Cat.#:BMPR1A-991HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein Receptor, Type IA, GST-tagged
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Cat.#:BMPR1A-2145HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR1A cell lysate
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Cat.#:BMPR1A-2466MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse BMPR1A cell lysate
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Involved Pathway

BMPR1A involved in several pathways and played different roles in them. We selected most pathways BMPR1A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMPR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL15; CCL25; VEGFA; IFNA14; CCL19; IL-8; Il23a; IL6ST; CXCL10; CCL3
TGF-beta signaling pathway
NOG; INHBE; ACVR1BA; FSTA; BMP2; SMAD7; ID2B; BMPR2; AMH; NDR1
Hippo signaling pathway
TEAD3; YAP1; PARD6B; TEAD1; FZD7; CRB1; SMAD4; WNT3A; BMP6; SMAD1
Signaling pathways regulating pluripotency of stem cells
WNT7A; FZD3; Fzd4; FZD6; KLF4; NEUROG1; WNT8B; AKT2; WNT11; NANOG

Protein Function

BMPR1A has several biochemical functions, for example, ATP binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMPR1A itself. We selected most functions BMPR1A had, and list some proteins which have the same functions with BMPR1A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2B; ABCA4; STYK1; UBE2L3A; PRKACBB; EPHA8; MYO1EB; ATP1A1A.3; MAP2K2A; TAE1
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein HIF3A; JUNBA; FOXP3A; ZNF131; FOXB1B; KLF11; SCAND1; FOXB1A; MED1; RELB
Function SMAD binding
Related Protein TOB1; SMAD2; DAB2; SOD3; PML; YY1; BMPR1B; EID2; EP300; TGFBR1
Function glycoprotein binding
Related Protein LMAN2; BMPR1B; Shh; OS9; CANX; Serpina1c; FBXO17; TGFB1; LACRT; FBXO27
Function metal ion binding
Related Protein PRDM5; SALL4; ACSM2; RTEL1; PPM1L; ZNF485; SIAH1A; SP2; CDH15; INO80B
Function protein binding
Related Protein PPP1R9A; PRF1; ASCL4; EPHA3; RARB; CLEC1B; TRPV4; C1orf51; AKTIP; KLHDC4
Function protein homodimerization activity
Related Protein DGCR8; BHLHB9; DMRTC1B; CHEK2; PDCD6; CARD8; S100A5; ANG; TKT; CHUK
Function protein serine/threonine kinase activity
Related Protein PAK2A; CDK12; HUNK; IRAK1; MAP4K6; ACVR2B; MAP2K4; AKT2L; LATS2; PRKCZ
Function receptor signaling protein serine/threonine kinase activity
Related Protein ACVR1C; BMPR2A; SLKA; TGFBR1; BMPR1BA; NEK4; STK25B; STK26; BMPR1BB; SBK3
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR1B; BMPR1BB; BMPR2A; ACVRL1; BMPR1A; BMPR1BA; TGFBR2; ACVR2A; BMPR2B; TGFBR1B

Interacting Protein

BMPR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMPR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of BMPR1A.
BMP2; GDF5; BMP4; BMP2; BMP2; FSTL1; HSP90AB1

BMPR1A Related Gene Family

TGF