• Official Full Name

    bone morphogenetic protein receptor, type II (serine/threonine kinase)

  • Overview

    BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-beta ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death
  • Synonyms

    BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1, primary pulmonary hypertension 1; bone morphogenetic protein receptor type-2; BMPR II; BMPR3; BRK 3; T ALK; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II ac;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Fc
  • Fc|His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • hFc
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMPR2-1367H Active Recombinant Human BMPR2, His-tagged Sf9 Insect Cell His
Human BMPR2-556H Active Recombinant Human BMPR2, Fc-tagged, Biotinylated Human Cell Fc
Human BMPR2-134H Recombinant Human BMPR2, His-tagged HEK293 His
Human BMPR2-870H Recombinant Human BMPR2 Protein, Fc/His-tagged HEK293 Fc/His
Human BMPR2-133H Active Recombinant Human BMPR2 protein, His&hFc-tagged HEK293 His&hFc
Human BMPR2-10258H Recombinant Human BMPR2, His-tagged E.coli His
Human BMPR2-993H Recombinant Human Bone Morphogenetic Protein Receptor, Type II, GST-tagged Sf9 Insect Cell His
Human BMPR2-577H Recombinant Human BMPR2 protein, His & T7-tagged E.coli His/T7
Human BMPR2-868H Recombinant Human BMPR2 Protein, His-tagged HEK293 His
Human BMPR2-287H Recombinant Human BMPR2 Protein, GST-tagged Sf21 Insect Cell GST
Human BMPR2-288H Recombinant Human BMPR2 Protein, GST-tagged Wheat Germ GST
Human BMPR2-2717HCL Recombinant Human BMPR2 cell lysate Human Cell N/A
Human BMPR2-451H-B Recombinant Human BMPR2 Protein Pre-coupled Magnetic Beads HEK293
Human BMPR2-451H Recombinant Human BMPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BMPR2-0770H Recombinant Human BMPR2 Protein (Ser27-Thr150), N-His tagged E.coli N-His
Human BMPR2-2707H Recombinant Human BMPR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BMPR2-1779HFL Recombinant Full Length Human BMPR2 Protein, C-Flag-tagged Mammalian cells Flag
Human BMPR2-1375H Recombinant Human BMPR2 Protein (Ser27-Ile151), C-His tagged Mammalian cells C-His
Mouse BMPR2-2440M Recombinant Mouse BMPR2 Protein Mammalian Cell His
Mouse BMPR2-1060M-B Recombinant Mouse BMPR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse BMPR2-1060M Recombinant Mouse BMPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bmpr2-715M Recombinant Mouse Bmpr2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque BMPR2-549R Recombinant Rhesus monkey BMPR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BMPR2-377R Recombinant Rhesus Macaque BMPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BMPR2-377R-B Recombinant Rhesus Macaque BMPR2 Protein Pre-coupled Magnetic Beads HEK293
Chicken BMPR2-1108C Recombinant Chicken BMPR2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BMPR2 Related Articles
  • BMPR2 Related Research Area

BMPR2 involved in several pathways and played different roles in them. We selected most pathways BMPR2 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFSF11;MPL;CCL28;IL12BA;Il4ra;CCL15;KDR;IL13RA1;CCL5
TGF-beta signaling pathwayE2F5;LFT2;RPS6KB1B;TGIF2;BMP8B;ROCK2B;IFNG1-2;CUL1B;BMP7A
Hippo signaling pathwayMOBKL1A;MPP5;INADL;TGFBR1;SMAD1;ID1;WNT8B;FZD5;LLGL1
Signaling pathways regulating pluripotency of stem cellsPIK3R1;MEIS1;FZD9;FGFR1;LIF;STAT3;INHBE;WNT3A;MAPK3

BMPR2 has several biochemical functions, for example, ATP binding, BMP binding, activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by BMPR2 itself. We selected most functions BMPR2 had, and list some proteins which have the same functions with BMPR2. You can find most of the proteins on our site.

Function Related Protein
activin receptor activity, type II
growth factor bindingLTBP2;FLT1;A2M;IGFBP2B;BMPR2;NRP2;LTBP4;ACVR1C;NKD2
metal ion bindingMAP3K4;ARHGAP29;CYP3C1L2;ZBTB6;ZNF789;TRPM6;IRF2BPL;ZNF726;CYP2AA4
protein bindingRNF149;ZNF624;SNX7;RPS27A;PPP3CC;S100A9;ERN1;NR0B2;ERG
receptor signaling protein serine/threonine kinase activityACVR2B;ACVR1L;SLKA;SBK3;OXSR1B;ACVR1;TGFBR1A;ACVR1BA;ACVR2AA

BMPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMPR2.

PRKG1; C4bpa; Prkcb; GDF5; MAPK8; Bmpr2; Ctbp1; Mos; Serpina3k; Lsp1; Cryab

Guignabert, C; Dorfmuller, P; et al. Pathology and Pathobiology of Pulmonary Hypertension. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE 34:551-559(2013).
Yu, J; Taylor, L; et al. Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension. JOURNAL OF CELLULAR PHYSIOLOGY 228:322-329(2013).
  • Q&As
  • Reviews

Q&As (7)

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What role does BMPR2 play in the development and progression of pulmonary arterial hypertension (PAH)? 02/01/2022

BMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.

What is the impact of BMPR2 mutations on hereditary hemorrhagic telangiectasia? 11/19/2020

Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.

How do alterations in BMPR2 expression or signaling affect embryonic development and congenital anomalies? 05/14/2020

Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.

What are the effects of BMPR2 dysregulation on renal function and kidney disease? 05/05/2020

Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.

How does BMPR2 mediate the signaling pathways of bone morphogenetic proteins (BMPs) in bone formation and remodeling? 06/01/2019

BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.

How does BMPR2 influence cardiovascular development and disease, particularly in heart valve formation? 01/20/2019

BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.

How does BMPR2 contribute to the regulation of cell proliferation and apoptosis in various tissues? 04/18/2018

BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.

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