Native Human C-abl Oncogene 1, Receptor Tyrosine Kinase

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Native Human C-abl Oncogene 1, Receptor Tyrosine Kinase

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Cat. No. : ABL1-618H
Product Overview : Native Human ABL1 is expressedinhuman plasma.
Description : HumanABL1 synthetic peptide can be used as a substrate for Abl kinase in in vitrokinase assays. It is phosphorylated by Abl kinase with a Km of 4 µM. ABL1 isa plasma membrane-associated non-receptor tyrosine kinase with transformingactivity wich requires its tyrosine kinase activity.
Source : human plasma
Form : Lyophilized
Molecular Weight : 1.337 g/mol
Purity : 90-95% as determinedby HPLC analysis
Reconstitution : Centrifuge vialprior to opening.Reconstitute with sterile distilled water.
Storage : Stable for 1 year at-20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : ABL1
PDBrendering based on 1ab2. :

Gene Name : ABL1 c-abl oncogene 1,non-receptor tyrosine kinase [ Homo sapiens ]
Synonyms : ABL1; c-abl oncogene 1,receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; bcr/c-abloncogene protein; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelsonmurine leukemia viral oncogene homolog 1; EC 2.7.10.2; Abelson murineleukemia viral oncogene homolog 1; OTTHUMP00000022375; OTTHUMP00000022376
Gene ID : 25
mRNA Refseq : NM_005157
Protein Refseq : NP_005148
MIM : 189980
UniProt ID : P00519
Chromosome Location : 9q34.1
Pathway : Axon guidance; Cell cycle;Chronic myeloid leukemia; ErbB signaling pathway; Neurotrophin signalingpathway; Pathogenic Escherichia coli infection; Pathways in cancer; T CellReceptor Signaling Pathway; TP53 network; Viral myocarditis; miRNAs involvedin DDR; p53 pathway; Role of Abl in Robo-Slit signaling; Shigellosis
Function : ATP binding; DNA binding;magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosinekinase activity; nucleotide binding; protein C-terminus binding; transferaseactivity

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