Native Human C-abl Oncogene 1, Receptor Tyrosine Kinase

• Cat.No.: ABL1-618H
• Product Overview: Native Human ABL1 is expressedinhuman plasma.

Specification

• Cat. No.: ABL1-618H
• Description: HumanABL1 synthetic peptide can be used as a substrate for Abl kinase in in vitrokinase assays. It is phosphorylated by Abl kinase with a Km of 4 µM. ABL1 isa plasma membrane-associated non-receptor tyrosine kinase with transformingactivity wich requires its tyrosine kinase activity.
• Source: human plasma
• Form: Lyophilized
• Molecular Weight: 1.337 g/mol
• Purity: 90-95% as determinedby HPLC analysis
• Reconstitution: Centrifuge vialprior to opening.Reconstitute with sterile distilled water.
• Storage: Stable for 1 year at-20°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ABL1

Gene Information

• Gene Name: ABL1 c-abl oncogene 1,non-receptor tyrosine kinase [ Homo sapiens ]
• Synonyms: ABL1; c-abl oncogene 1,receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; bcr/c-abloncogene protein; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelsonmurine leukemia viral oncogene homolog 1; EC 2.7.10.2; Abelson murineleukemia viral oncogene homolog 1; OTTHUMP00000022375; OTTHUMP00000022376
• Gene ID: 25
• mRNA Refseq: NM_005157
• Protein Refseq: NP_005148
• MIM: 189980
• UniProt ID: P00519
• Chromosome Location: 9q34.1
• Pathway: Axon guidance; Cell cycle;Chronic myeloid leukemia; ErbB signaling pathway; Neurotrophin signalingpathway; Pathogenic Escherichia coli infection; Pathways in cancer; T CellReceptor Signaling Pathway; TP53 network; Viral myocarditis; miRNAs involvedin DDR; p53 pathway; Role of Abl in Robo-Slit signaling; Shigellosis
• Function: ATP binding; DNA binding;magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosinekinase activity; nucleotide binding; protein C-terminus binding; transferaseactivity