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Recombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase)

Cat.No. : KDR-5447H
Product Overview : Recombinant HumanKDR is produced as a non-chimeric protein in a monomeric form, which has aMW=116 kDa.
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Cat. No. : KDR-5447H
Description : KDR, belonging to the family of receptortyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1),VEGFR-3 (Flt-4). Their expression is almost exclusively restricted toendothelial cells, but VEGFR-1 can also be found on monocytes. All KDR have seven immunoglobulin-like extracellulardomains, a single transmembrane region and an intracellular split tyrosinekinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor,but a higher signaling activity. Mitogenic activity in endothelial cells ismainly mediated by VEGFR-2 leading to their proliferation. Differentialsplicing of the flt-1 gene leads to the formation of a secreted, solublevariant of VEGFR-1 (KDR). No naturally occurring, secreted formsof VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 isdependent on heparin.
Source : Insect cells
Species : Human
Form : Lyophilized from abuffer of 20 mM Tris + 150 mM NaCl, pH 8.0.
Molecular Weight : 116 kDa
Purity : > 90% by SDS-PAGEand visualized by silver stain
Endotoxin Level : < 0.1 ng/µg ofsKDR
Biological Activity : The activity ofrecombinant human sVEGFR-2 was determined by its ability to abolish the bindingof iodinated VEGF to solid surfaces or cell surfaces. The ED50 for thiseffect is typically 10.0 ng/ml.
Reconstitution : Centrifuge vialprior to opening. The lyophilized human sKDR is soluble in water and mostaqueous buffers. The lyophilized powder should be reconstituted in water orPBS to a concentration not lower than 100 µg/ml.
Storage : The material isstable for greater than six months at -20°C to -80°C. After the first thawingit is recommended to aliquot the material in order to avoid repeated freeze-thawcycles. Store at 2-4°C not longer than 2 days.
OfficialSymbol : KDR
Gene Name : KDR kinase insert domainreceptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Synonyms : KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2;vascular endothelial growth factor receptor 2; soluble VEGFR2;OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1;protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor; EC 2.7.10; EC 2.7.10.1
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968
Chromosome Location : 4q11-q12
Pathway : Angiogenesis;Cytokine-cytokine receptor interaction; Endocytosis; Focal Adhesion;HIF-2-alpha transcription factor network; Id Signaling Pathway; Integrins inangiogenesis; Neurophilin interactions with VEGF and VEGFR; Notch-mediatedHES/HEY network; S1P1 pathway; Signal Transduction; Signaling events mediatedby VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization;VEGF ligand-receptor interactions; VEGF signaling pathway
Function : ATP binding; Hsp90protein binding; growth factor binding; integrin binding; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity;receptor signaling protein tyrosine kinase activity; transmembrane receptorprotein tyrosine kinase activity; vascular endothelial growthfactor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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