Recombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), GST-tagged

• Cat.No.: MET-1271H
• Product Overview: Recombinant humanMET is expressed in insect cells, 53.7 kDa and N-terminal GST tag.

Specification

• Cat. No.: MET-1271H
• Description: MET is a receptor-liketyrosine kinase comprised of disulfide-linked heterodimeric structure with a50-kDa extracellular « chain and a 145-kDa extracellular transmembrane chain.The methionine at residue 1250 has been replaced by threonine to mimic a drugresistant form of MET.
• Source: insect cells
• Species: Human
• Form: Liquid in a bufferof 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% Glycerol
• Molecular Weight: 53.7 kDa
• Concentration: 0.31 mg/ml
• Purity: > 70% asdetermined by SDS-PAGE analysis
• Specific Activity: ≥ 100 nmolphosphate transferred to Myelin Basic Protein (MBP) substrate/min/mg
• Storage: Store in workingaliquots at -80°C. Product is stable for 6 months when stored as directed. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: MET

Gene Information

• Gene Name: MET met proto-oncogene(hepatocyte growth factor receptor) [ Homo sapiens ]
• Synonyms: MET; metproto-oncogene (hepatocyte growth factor receptor); HGFR; AUTS9; RCCP2;c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; oncogeneMET; HGF/SF receptor; OTTHUMP00000024917; OTTHUMP00000069168; proto-oncogenec-Met; scatter factor receptor; tyrosine-protein kinase Met; metproto-oncogene tyrosine kinase; EC 2.7.10.1; EC 2.7.10
• Gene ID: 4233
• mRNA Refseq: NM_000245
• Protein Refseq: NP_000236
• MIM: 164860
• UniProt ID: P08581
• Chromosome Location: 7q31
• Pathway: Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Bacterial invasion of epithelialcells; Cytokine-cytokine receptor interaction; Developmental Biology;Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; FGFsignaling pathway; Melanoma; Pathways in cancer; Renal cell carcinoma;Semaphorin interactions; Signaling events mediated by TCPTP;Syndecan-1-mediated signaling events
• Function: ATP binding;hepatocyte growth factor-activated receptor activity; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity