"MET" Related Products

Recombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), GST-tagged

Cat. No. : MET-1271H
Product Overview : Recombinant humanMET is expressed in insect cells, 53.7 kDa and N-terminal GST tag.
Description : MET is a receptor-liketyrosine kinase comprised of disulfide-linked heterodimeric structure with a50-kDa extracellular « chain and a 145-kDa extracellular transmembrane chain.The methionine at residue 1250 has been replaced by threonine to mimic a drugresistant form of MET.
Source : insect cells
Species : Human
Form : Liquid in a bufferof 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% Glycerol
Molecular Weight : 53.7 kDa
Concentration : 0.31 mg/ml
Purity : > 70% asdetermined by SDS-PAGE analysis
Specific Activity : ≥ 100 nmolphosphate transferred to Myelin Basic Protein (MBP) substrate/min/mg
Storage : Store in workingaliquots at -80°C. Product is stable for 6 months when stored as directed. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : MET
Crystallographicstructure of MET. PDB rendering based on 1r0p. :

Gene Name : MET met proto-oncogene(hepatocyte growth factor receptor) [ Homo sapiens ]
Synonyms : MET; metproto-oncogene (hepatocyte growth factor receptor); HGFR; AUTS9; RCCP2;c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; oncogeneMET; HGF/SF receptor; OTTHUMP00000024917; OTTHUMP00000069168; proto-oncogenec-Met; scatter factor receptor; tyrosine-protein kinase Met; metproto-oncogene tyrosine kinase; EC; EC 2.7.10
Gene ID : 4233
mRNA Refseq : NM_000245
Protein Refseq : NP_000236
MIM : 164860
UniProt ID : P08581
Chromosome Location : 7q31
Pathway : Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Bacterial invasion of epithelialcells; Cytokine-cytokine receptor interaction; Developmental Biology;Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; FGFsignaling pathway; Melanoma; Pathways in cancer; Renal cell carcinoma;Semaphorin interactions; Signaling events mediated by TCPTP;Syndecan-1-mediated signaling events
Function : ATP binding;hepatocyte growth factor-activated receptor activity; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity

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