Active Recombinant Human STK19, GST-tagged

• Cat.No.: STK19-263H
• Product Overview: Recombinant full-length human STK19 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: STK19 is a member of the serine/threonine kinase family that shows a manganese-dependent protein kinase activity and phosphorylates α-casein at ser/thr residues and histone at ser residues. STK19 contains a positively charged putative nuclear localization signal, multiple potential phosphorylation sites, 2 amidation sites, 9 potential N-myristoylation sites, and no N-glycosylation sites. STK19 has been shown to localize predominantly in the nucleus. The phosphorylation of STK19 is thought to be involved in transcriptional regulation. STK19 localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: The specific activity of STK19 was determined to be 2 nmol /min/mg
• Molecular Mass: ~70 kDa
• Purity: >70% by densitometry
• Applications: Kinase Assay, Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 μg/μl

Gene Information

• Gene Name: STK19 serine/threonine kinase 19 [ Homo sapiens ]
• Official Symbol: STK19
• Synonyms: STK19; serine/threonine kinase 19; serine/threonine-protein kinase 19; D6S60; G11; RP1; MHC class III HLA-RP1; nuclear serine/threonine protein kinase; D6S60E; HLA-RP1; MGC117388
• Gene ID: 8859
• mRNA Refseq: NM_004197
• Protein Refseq: NP_004188
• MIM: 604977
• UniProt ID: P49842
• Chromosome Location: 6p21.33
• Function: ATP binding; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity