"Ephb1" Related Products


Recombinant Mouse Eph Receptor B1, GST-tagged, Active

Cat. No. : Ephb1-303M
Product Overview : Recombinant mouse Ephb1 (591-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=62kDa.
Description : EPHB1 is a member of the Eph family of receptor tyrosine kinases. Ligand-activated EPHB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration. In addition, activated EPHB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation. Expression of dominant-negative c-Src significantly reduced EPHB1-dependent ERK1/2 activation and chemotaxis.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 591-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : Ephb1 Eph receptor B1 [ Mus musculus ]
Synonyms : Ephb1; Eph receptor B1; Elk; Net; Cek6; Elkh; Hek6; AW488255; 9330129L11; C130099E04Rik; ENSMUSG00000074119
Gene ID : 270190
mRNA Refseq : NM_001168296
Protein Refseq : NP_001161768
UniProt ID : Q8CBF3
Chromosome Location : 9F1
Pathway : Axon guidance
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity; protein kinase activity; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity

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