Recombinant Human GCK
Cat.No. : | GCK-28593TH |
Product Overview : | Recombinant full length human IGLK; amino acids 1-465, 52kDa. |
- Specification
- Gene Information
- Related Products
Description : | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
Source : | E. coli |
Tissue specificity : | Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the hexokinase family. |
Gene Name : | GCK glucokinase (hexokinase 4) [ Homo sapiens ] |
Official Symbol : | GCK |
Synonyms : | GCK; glucokinase (hexokinase 4); maturity onset diabetes of the young 2 , MODY2; glucokinase; HK4; |
Gene ID : | 2645 |
mRNA Refseq : | NM_000162 |
Protein Refseq : | NP_000153 |
MIM : | 138079 |
Uniprot ID : | P35557 |
Chromosome Location : | 7p15.3-p15.1 |
Pathway : | Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Butirosin and neomycin biosynthesis, organism-specific biosystem; Butirosin and neomycin biosynthesis, conserved biosystem; Developmental Biology, organism-specific biosystem; |
Function : | ATP binding; glucokinase activity; glucose binding; kinase activity; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
GCK-2198H | Recombinant Human GCK Protein, His-tagged | +Inquiry |
GCK-972H | Recombinant Human GCK Protein, His (Fc)-Avi-tagged | +Inquiry |
GCK-0261H | Recombinant Human GCK Protein (M1-Q465), His tagged | +Inquiry |
GCK-0260H | Recombinant Human GCK Protein (M1-Q465), Tag Free | +Inquiry |
GCK-658H | Recombinant Human GCK Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
GCK-5985HCL | Recombinant Human GCK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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