Recombinant Human MAPKAPK2

• Cat.No.: MAPKAPK2-27128TH
• Product Overview: Recombinant fragment, corresponding to amino acids 46-end of Human MAPKAP Kinase 2, expressed by baculovirus in Sf9 insect cells, with an N-terminal tag, MW 68 kDa.

Specification

• Description: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
• Tissue specificity: Expressed in all tissues examined.
• Biological activity: Specific activity: 254 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 [ Homo sapiens ]
• Official Symbol: MAPKAPK2
• Synonyms: MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2
• Gene ID: 9261
• mRNA Refseq: NM_004759
• Protein Refseq: NP_004750
• MIM: 602006
• Uniprot ID: P49137
• Chromosome Location: 1q32
• Pathway: Activated TLR4 signalling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity