Recombinant Full Length Human PRC1 Protein, MYC/DDK-tagged
Cat.No. : | PRC1-2915H |
Product Overview : | Recombinant Human PRC1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
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Description : | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 71.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | PRC1 protein regulator of cytokinesis 1 [ Homo sapiens ] |
Official Symbol : | PRC1 |
Synonyms : | ASE1; ASE1 |
Gene ID : | 9055 |
mRNA Refseq : | NM_003981 |
Protein Refseq : | NP_003972 |
MIM : | 603484 |
UniProt ID : | O43663 |
Products Types
◆ Recombinant Protein | ||
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Prc1-5097M | Recombinant Mouse Prc1 Protein, Myc/DDK-tagged | +Inquiry |
PRC1-3585C | Recombinant Chicken PRC1 | +Inquiry |
PRC1-527H | Recombinant Human PRC1 Protein, His-tagged | +Inquiry |
PRC1-528H | Recombinant Human PRC1 protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
PRC1-5267P | Active Native Yeast Carboxypeptidase Y Protein | +Inquiry |
◆ Lysates | ||
PRC1-459HCL | Recombinant Human PRC1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt has high safety, environmental protection and no pollution.
The quality is so good, it greatly saves the experimental time, very good.
The preparation cost is low and cost-effective, which is very suitable for our research.
Q&As (6)
Ask a questionThe activity of PRC1 can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the interaction of PRC1 with microtubules and its function in cell division.
PRC1 promotes chromosome segregation and cytoplasmic equalization during metaphase of cell division by interacting with microtubules. It is also involved in the process of cell plate formation.
It interacts with other proteins, such as microtubule-associated proteins and cyclins. These interactions help regulate the function of PRC1 in cell division.
PRC1 plays an important role in stem cell and tissue regeneration. It is involved in the process of stem cell self-renewal and differentiation, as well as the cell cycle regulation of tissue regeneration.
Drug development for PRC1 is ongoing. Several research teams are developing small molecule inhibitors or activators that modulate PRC1 activity for the treatment of PRC1-related diseases.
The expression level of PRC1 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the PRC1 gene, thereby regulating its expression level in cells.
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