Recombinant Human PRC1 Protein, His-tagged
Cat.No. : | PRC1-527H |
Product Overview : | Recombinant human PRC1 isoform 1 (NP_003972.1) (Met 1-Ser 620) was expressed, with a polyhistidine tag at the N-terminus. |
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Source : | Baculovirus-Insect Cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met |
Form : | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 20% gly, 3mM DTT, 5%~8% trehalose and mannitol. |
Molecular Mass : | The recombinant human PRC1 consists of 639 amino acids and predicts a molecular mass of 74 kDa. It migrates as an approximately 75 KDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | PRC1 protein regulator of cytokinesis 1 [ Homo sapiens ] |
Official Symbol : | PRC1 |
Synonyms : | PRC1; protein regulator of cytokinesis 1; anaphase spindle elongation 1 homolog (S. cerevisiae); ASE1; protein regulating cytokinesis 1; anaphase spindle elongation 1 homolog; MGC1671; MGC3669; |
Gene ID : | 9055 |
mRNA Refseq : | NM_003981 |
Protein Refseq : | NP_003972 |
MIM : | 603484 |
UniProt ID : | O43663 |
Chromosome Location : | 15q26.1 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe activity of PRC1 can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the interaction of PRC1 with microtubules and its function in cell division.
PRC1 promotes chromosome segregation and cytoplasmic equalization during metaphase of cell division by interacting with microtubules. It is also involved in the process of cell plate formation.
It interacts with other proteins, such as microtubule-associated proteins and cyclins. These interactions help regulate the function of PRC1 in cell division.
PRC1 plays an important role in stem cell and tissue regeneration. It is involved in the process of stem cell self-renewal and differentiation, as well as the cell cycle regulation of tissue regeneration.
Drug development for PRC1 is ongoing. Several research teams are developing small molecule inhibitors or activators that modulate PRC1 activity for the treatment of PRC1-related diseases.
The expression level of PRC1 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the PRC1 gene, thereby regulating its expression level in cells.
Customer Reviews (3)
Write a reviewIt has high safety, environmental protection and no pollution.
The quality is so good, it greatly saves the experimental time, very good.
The preparation cost is low and cost-effective, which is very suitable for our research.
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