PRC1
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Official Full Name
protein regulator of cytokinesis 1
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Overview
Protein Regulator of Cytokinesis 1 (PRC1) is involved in cytokinesis. PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in vivo CDK substrate. PRC1 protein levels are high during S and G2/M and drop dramatically after cells exit mitosis and enter G1. PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage,Is a microtubule binding and bundling protein both in vivo and in vitro. Overexpression of PRC1 extensively bundles interphase microtubules, but does -
Synonyms
PRC1; protein regulator of cytokinesis 1; anaphase spindle elongation 1 homolog (S. cerevisiae); ASE1; protein regulating cytokinesis 1; anaphase spindle elongation 1 homolog; MGC1671; MGC3669;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Human
- Mouse
- Yeast
- E. coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | PRC1-527H | Recombinant Human PRC1 Protein, His-tagged | Insect Cell | His | ||
| Human | PRC1-459HCL | Recombinant Human PRC1 cell lysate | Insect Cell | N/A |
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| Human | PRC1-2915H | Recombinant Human PRC1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | PRC1-1755H | Recombinant Human PRC1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | PRC1-528H | Recombinant Human PRC1 protein, GST-tagged | E. coli | GST | 13-175 aa |
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| Human | PRC1-1623HFL | Recombinant Full Length Human PRC1 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | PRC1-1755H-B | Recombinant Human PRC1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Prc1-5097M | Recombinant Mouse Prc1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Yeast | PRC1-5267P | Active Native Yeast PRC1 Protein | Yeast | N/A |
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| Chicken | PRC1-3585C | Recombinant Chicken PRC1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PRC1 Related Articles
PRC1 involved in several pathways and played different roles in them. We selected most pathways PRC1 participated on our site, such as RHO GTPase Effectors, RHO GTPases activate CIT, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPase Effectors | BAIAP2;ZWINT;RHPN2;NCKAP1;ERCC6L;CCDC99;KNTC1;KIF14;CLIP1 |
| RHO GTPases activate CIT | PRC1;CIT;KIF14;PRC1B;RHOAE |
| Signal Transduction | OTULINB;CCNT2A;OPN4.1;GPBAR1;ZFPM2B;EDNRAB;METAP2;MYO7AA;NMB |
| Signaling by Rho GTPases | TAGAPA;ARHGAP11A;MKL1;FMNL2;RHOU;DCLRE1B;RHOUA;IQGAP3;RHOJ |
PRC1 has several biochemical functions, for example, identical protein binding, kinesin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRC1 itself. We selected most functions PRC1 had, and list some proteins which have the same functions with PRC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NFKBIA;C1QL4;CXADR;SCHIP1;CD28;SIAH1A;FAS;BRAF;LRRK2 |
| kinesin binding | SNCA;AP1AR;ATCAY;KIFAP3;SPAG9A;PRC1;FAM83D;KLC3;JAKMIP1 |
| microtubule binding | MAPRE3A;EML1;KIF2A;NDEL1A;KIF3A;MAPT;KIF5B;CETN2;WDR81 |
| protein binding | PIKFYVE;ACTL7A;TCOF1;PTPRA;MRPL28;CD72;CDK2AP1;ZC3H8;FXYD7 |
| protein kinase binding | ZFP36;ATF2;PXN;PDPK1;TP53;VRK2;NBEA;CCNL2;AP2A1 |
PRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRC1.
TRIM37; USHBP1; Dlg4; Racgap1; KRT20; CCDC85B; PTBP3; EXOSC2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of PRC1 can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the interaction of PRC1 with microtubules and its function in cell division.
PRC1 promotes chromosome segregation and cytoplasmic equalization during metaphase of cell division by interacting with microtubules. It is also involved in the process of cell plate formation.
It interacts with other proteins, such as microtubule-associated proteins and cyclins. These interactions help regulate the function of PRC1 in cell division.
PRC1 plays an important role in stem cell and tissue regeneration. It is involved in the process of stem cell self-renewal and differentiation, as well as the cell cycle regulation of tissue regeneration.
Drug development for PRC1 is ongoing. Several research teams are developing small molecule inhibitors or activators that modulate PRC1 activity for the treatment of PRC1-related diseases.
The expression level of PRC1 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the PRC1 gene, thereby regulating its expression level in cells.
Customer Reviews (3)
Write a reviewIt has high safety, environmental protection and no pollution.
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