What is CHMP2A Protein
CHMP2A, officially known as Charged Multivesicular Body Protein 2A, is a critical player in cellular processes with various synonyms such as Chromatin Modifying Protein 2A, VPS2-1, and hSnf7-1. Belonging to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family, CHMP2A plays a pivotal role in endosomal sorting and cellular membrane dynamics.
This protein, characterized by its structural intricacies, is classified as a member of the AAA ATPase family and the ESCRT-III (endosomal sorting complex required for transport III) complex. Recent research advances have shed light on the nuanced functions and regulatory mechanisms of CHMP2A, expanding our understanding of cellular homeostasis.
CHMP2A Biological Functions and Molecular Mechanisms
The biological functions of CHMP2A are diverse and impactful. Primarily involved in the process of multivesicular body (MVB) formation, CHMP2A participates in the sorting and trafficking of cellular cargo destined for degradation. This is achieved through its role in the ESCRT-III complex, a molecular machinery responsible for the formation of intraluminal vesicles within endosomes, ultimately leading to the creation of MVBs.
Molecular mechanisms underlying CHMP2A function include its interaction with other ESCRT-III components, orchestrating a finely-tuned process of cargo recognition, membrane deformation, and vesicle scission. This dynamic interplay ensures the proper removal of obsolete or damaged cellular components, contributing to cellular maintenance and homeostasis.
Figure 1. The proposed mechanism of CHMP2A KO in tumor cells. (Bernareggi D, et al., 2022)
CHMP2A Related Signaling Pathway
The signaling pathways involving CHMP2A are intricately linked to endosomal sorting and membrane dynamics. As a core component of the ESCRT-III complex, CHMP2A is engaged in the downregulation of cell surface receptors, modulating their intracellular trafficking and subsequent degradation. This process is crucial for the regulation of various signaling pathways, impacting cellular responses to external stimuli.
CHMP2A Related Diseases
Anomalies in CHMP2A expression or function have been associated with various diseases, highlighting its significance in maintaining cellular health. Mutations in CHMP2A have been linked to neurodegenerative disorders, including frontotemporal dementia (FTD). Research suggests that dysregulation of the ESCRT machinery, including CHMP2A, may contribute to the pathological accumulation of protein aggregates seen in FTD and other related conditions.
CHMP2A's Applications in Biomedicine
The versatility of CHMP2A extends beyond its fundamental cellular functions, making it a promising candidate for biomedical applications. In diagnostic development, CHMP2A can serve as a potential biomarker for conditions associated with ESCRT dysfunction, aiding in the early detection and monitoring of diseases such as FTD.
Furthermore, CHMP2A's involvement in cellular membrane dynamics positions it as a valuable player in vaccine development. Understanding its role in antigen presentation and endosomal processing provides a foundation for designing vaccines that harness the body's natural mechanisms for immune response, potentially enhancing vaccine efficacy.
In the realm of therapeutics, the modulation of CHMP2A function presents a novel avenue for targeted interventions. Developing pharmaceuticals that regulate the ESCRT machinery could hold promise for conditions where aberrant cellular clearance contributes to pathology, such as neurodegenerative diseases.
Recommended Products
| Cat.# | Product name | Species | Source (Host) | Tag |
|---|---|---|---|---|
| CHMP2A-4011H | Recombinant Human CHMP2A Protein, Myc/DDK-tagged, C13 and N15-labeled | Human | HEK293T | Myc/DDK |
| CHMP2A-11184H | Recombinant Human CHMP2A, GST-tagged | Human | E.coli | GST |
| CHMP2A-1396H | Recombinant Human Chromatin Modifying Protein 2A, His-tagged | Human | E.coli | His |
| CHMP2A-3205HF | Recombinant Full Length Human CHMP2A Protein, GST-tagged | Human | In Vitro Cell Free System | GST |
| CHMP2A-26719TH | Recombinant Human CHMP2A, His-tagged | Human | E.coli | His |
| CHMP2A-27958TH | Recombinant Human CHMP2A, His-tagged | Human | E.coli | His |
| CHMP2A-1249H | Recombinant Human CHMP2A Protein, GST-Tagged | Human | Wheat Germ | GST |
| CHMP2A-5210H | Recombinant Human CHMP2A protein, GST-tagged | Human | E.coli | GST |
| Chmp2a-2146M | Recombinant Mouse Chmp2a Protein, Myc/DDK-tagged | Mouse | HEK293T | Myc/DDK |
| CHMP2A-1650M | Recombinant Mouse CHMP2A Protein, His (Fc)-Avi-tagged | Mouse | HEK293 | His (Fc)-Avi |
Reference
- Bernareggi D, et al. CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity. Nature Communications. 2022, 13(1): 1899.
