Recombinant Human CHMP2A Protein, GST-Tagged

• Cat.No.: CHMP2A-1249H
• Product Overview: Human CHMP2A full-length ORF (NP_055268, 1 a.a. - 222 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 50.05 kDa
• AA Sequence: MDLLFGRRKTPEELLRQNQRALNRA MRELDRERQKLETQEKKIIADIKKM AKQGQMDAVRIMAKDLVRTRRYVRK FVLMRANIQAVSLKIQTLKSNNSMA QAMKGVTKAMGTMNRQLKLPQIQKI MMEFERQAEIMDMKEEMMNDAIDDA MGDEEDEEESDAVVSQVLDELGLSL TDELSNLPSTGGSLSVAAGGKKAEA AASALADADADLEERLKNLRRD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CHMP2A charged multivesicular body protein 2A [ Homo sapiens ]
• Official Symbol: CHMP2A
• Synonyms: CHMP2A; charged multivesicular body protein 2A; chromatin modifying protein 2A; charged multivesicular body protein 2a; BC 2; CHMP2; putative breast adenocarcinoma marker (32kD); VPS2; VPS2 homolog A (S. cerevisiae); VPS2A; vps2-1; hVps2-1; VPS2 homolog A; chromatin-modifying protein 2a; putative breast adenocarcinoma marker BC-2; vacuolar protein sorting-associated protein 2-1; BC2; BC-2
• Gene ID: 27243
• mRNA Refseq: NM_014453
• Protein Refseq: NP_055268
• MIM: 610893
• UniProt ID: O43633