A4GALT Protein, Alpha 1,4-Galactosyltransferase

A4GALT

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A4GALT

Official Full Name Alpha 1,4-Galactosyltransferase
Background The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.
Synonyms A4GALT; alpha 1,4-galactosyltransferase; P1; PK; Gb3S; P(k); A14GALT; A4GALT1; lactosylceramide 4-alpha-galactosyltransferase; GB3 synthase; alpha4Gal-T1; CD77 synthase; P1/Pk synthase; P(k) antigen synthase; P blood group (P one antigen); globotriaosylceramide synthase; alpha-1,4-N-acetylglucosaminyltransferase; UDP-galactose: beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase; NP_059132.1; EC 2.4.1.228
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human A4GALT-005H Recombinant Human A4GALT Protein, GST-tagged Wheat Germ GST
    Human A4GALT-483H Recombinant Human A4GALT Protein, His-tagged E.coli His
    Human A4GALT-9163HCL Recombinant Human A4GALT 293 Cell Lysate HEK293 N/A
    Human A4GALT-9186H Recombinant Human A4GALT, GST-tagged E.coli GST
    Human A4GALT-9187H Recombinant Human A4GALT protein, GST-tagged Wheat Germ GST
    Mouse A4galt-484M Recombinant Mouse A4galt Protein, His-tagged E.coli His
    Rat A4GALT-379R Recombinant Rat A4GALT Protein Mammalian Cell His
    Rat A4galt-485R Recombinant Rat A4galt Protein, His-tagged E.coli His
    Chicken A4GALT-5510C Recombinant Chicken A4GALT Mammalian Cell His

    A4GALT involved in several pathways and played different roles in them. We selected most pathways A4GALT participated on our site, such as Glycosphingolipid biosynthesis - globo series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with A4GALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosphingolipid biosynthesis - globo series NAGA; GBGT1L4; FUT1; ST3GAL1; FUT2; HEXA; FUT9; A4GALT; GBGT1; ST8SIA1
    Metabolic pathways GGT1; HGD; TBXAS1; SLC27A5; NMNAT1; PAFAH1B1; UGP2A; ACSM1; ADPGK; GNE

    A4GALT has several biochemical functions, for example, galactosyltransferase activity, lactosylceramide 4-alpha-galactosyltransferase activity, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A4GALT itself. We selected most functions A4GALT had, and list some proteins which have the same functions with A4GALT. You can find most of the proteins on our site.

    Function Related Protein
    galactosyltransferase activity B3GNT7L; B4GALT2; B4GALT1; UGGT1; B3GNT2; B3GNT5A; B3GNT8; POC1BL; GALNT18A; B3GNT2B
    lactosylceramide 4-alpha-galactosyltransferase activity A4GALT
    toxic substance binding A4GALT; GUCY2C; CHRNA7; ASS1; NEFH; Alb; EPHX2; H2-AB1; AZU1; DSG1

    A4GALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A4GALT here. Most of them are supplied by our site. Hope this information will be useful for your research of A4GALT.

    Dlg4; rab40c

    Lai, YJ; Wu, WY; et al. A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P-1/P-2 blood groups. TRANSFUSION 54:3222-3231(2014).
    Westman, JS; Hellberg, A; et al. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles. TRANSFUSION 54:1831-1835(2014).

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