a4galt
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  • Official Full Name
  • Alpha 1,4-Galactosyltransferase
  • Background
  • The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.
  • Synonyms
  • A4GALT; alpha 1,4-galactosyltransferase; P1; PK; Gb3S; P(k); A14GALT; A4GALT1; lactosylceramide 4-alpha-galactosyltransferase; GB3 synthase; alpha4Gal-T1; CD77 synthase; P1/Pk synthase; P(k) antigen synthase; P blood group (P one antigen); globotriaosylceramide synthase; alpha-1,4-N-acetylglucosaminyltransferase; UDP-galactose: beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase; NP_059132.1; EC 2.4.1.228
Cat.#:A4GALT-483HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human A4GALT Protein, His-tagged
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Cat.#:A4galt-484MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse A4galt Protein, His-tagged
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Cat.#:A4galt-485RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat A4galt Protein, His-tagged
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Cat.#:A4GALT-005HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human A4GALT Protein, GST-tagged
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Cat.#:A4GALT-9186HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human A4GALT, GST-tagged
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Cat.#:A4GALT-9187HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human A4GALT protein, GST-tagged
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Cat.#:A4GALT-379RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat A4GALT Protein
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Cat.#:A4GALT-5510CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken A4GALT
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Cat.#:A4GALT-9163HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human A4GALT 293 Cell Lysate
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Involved Pathway

A4GALT involved in several pathways and played different roles in them. We selected most pathways A4GALT participated on our site, such as Glycosphingolipid biosynthesis - globo series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with A4GALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosphingolipid biosynthesis - globo series
ST8SIA1; GLA; FUT9A; B3GALNT1; GBGT1L4; A4GALT; FUT2; HEXB; NAGA; GBGT1
Metabolic pathways
DLDH; SCLY; ME3; DHRS13L1; IMPDH1B; SMPD1; NDUFS2; ATP5A1; NDUFB10; PLCB4

Protein Function

A4GALT has several biochemical functions, for example, galactosyltransferase activity, lactosylceramide 4-alpha-galactosyltransferase activity, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A4GALT itself. We selected most functions A4GALT had, and list some proteins which have the same functions with A4GALT. You can find most of the proteins on our site.
Function
Related Protein
Function galactosyltransferase activity
Related Protein B3GNT2A; B3GNTL1; B4GALT1; B3GALT6; UGGT1; A4GALT; B3GALNT2; B3GNT6; B4GALT5; B3GNT7L
Function lactosylceramide 4-alpha-galactosyltransferase activity
Related Protein A4GALT
Function toxic substance binding
Related Protein GUCY2C; CHRNA7; PHAX; ASS1; EPHX2; NEFH; A4GALT; Alb; AZU1; DSG1

Interacting Protein

A4GALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A4GALT here. Most of them are supplied by our site. Hope this information will be useful for your research of A4GALT.
Dlg4; rab40c

A4GALT Related Articles

Lai, YJ; Wu, WY; et al. A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P-1/P-2 blood groups. TRANSFUSION 54:3222-3231(2014).
Westman, JS; Hellberg, A; et al. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles. TRANSFUSION 54:1831-1835(2014).