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ABCA3

  • Official Full Name

    ATP-binding cassette, sub-family A (ABC1), member 3

  • Overview

    ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.
  • Synonyms

    ABCA3; ATP-binding cassette, sub-family A (ABC1), member 3; ABC3; ATP-binding cassette sub-family A member 3; ABC C; EST111653; LBM180; ABC transporter 3; ABC-C transporter; ATP-binding cassette transporter 3; ABC-C; SMDP3; MGC72201; MGC166979;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCA3-546H Recombinant Human ABCA3 Mammalian Cell His
Human ABCA3-9205H Recombinant Human ABCA3, GST-tagged E.coli GST 1-209a.a.
Human ABCA3-8114H Recombinant Human ABCA3 protein, His & T7-tagged E.coli His/T7 Asp1358~Phe1635 (Accession # Q99758)
Human ABCA3-2HCL Recombinant Human ABCA3 lysate HEK293 N/A
Human ABCA3-1861H Recombinant Human ABCA3 protein, GST-tagged E.coli GST 1606 - 1704 aa
Human ABCA3-2399H Recombinant Human ABCA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ABCA3-2399H-B Recombinant Human ABCA3 Protein Pre-coupled Magnetic Beads HEK293
Human ABCA3-0508H Recombinant Human ABCA3 Protein (Asp1358-Phe1635), N-His-tagged E.coli N-His Asp1358-Phe1635
Mouse ABCA3-1079M Recombinant Mouse ABCA3 Protein Mammalian Cell His
Mouse ABCA3-181M-B Recombinant Mouse ABCA3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABCA3-181M Recombinant Mouse ABCA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABCA3 Related Articles

ABCA3 involved in several pathways and played different roles in them. We selected most pathways ABCA3 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersAbca2;TAP2;ABCC4;ABCG2;ABCA7;ABCB9;ABCB7;ABCC3;ABCD2

ABCA3 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA3 itself. We selected most functions ABCA3 had, and list some proteins which have the same functions with ABCA3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingP2RX2;PRKACA;PARS2;HSP90AA1.1;BAZ1B;ZAP70;MATK;KCNJ11;DNAJA1
ATPase activity, coupled to transmembrane movement of substancesABCA1B;ABCB6;ABCA1;Abcb1b;ABCA6;ABCB4;ABCG2D;ABCC3;ABCA7
transporter activityLCN9;SLCO1A4;AP4B1;CHP1;SLC4A2A;TTPAL;AP1S2;CPNE6;SEC22A

ABCA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA3.

CANX; LAMP3

Park, SK; Dahmer, MK; et al. MAPK and JAK-STAT Signaling Pathways are Involved in the Oxidative Stress - Induced Decrease in Expression of Surfactant Protein Genes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 30:334-346(2012).
Buckley, S; Shi, W; et al. The Milieu of Damaged Alveolar Epithelial Type 2 Cells Stimulates Alveolar Wound Repair by Endogenous and Exogenous Progenitors. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 45:1212-1221(2011).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the function of ABCA3? 04/14/2023

ABCA3 catalyzes the ATP-dependent transport of phospholipids such as phosphatidylglycerol and phosphatidylcholine from the cytoplasm to the lumen of the lamellar bodies, and then participates in lamellar bodies biogenesis and homeostasis of lung surfactant. Preferential transport of phosphatidylcholine containing short acyl chains. In addition, it acts as an efflux transporter for miltefosine across the macrophage membrane, as well as through intralumenal vesicles to remove free cholesterol (FC) as a surfactant component and protect cells from free cholesterol toxicity.

How pure is your ABCA3 product? 04/14/2023

The purity of our recombinant proteins is generally above 80%. And we can produce higher purity ABCA3 protein according to your requirements, such as crystalline grade protein.

I am going to purchase ABCA3 products, will you provide detailed instructions for use? 04/14/2023

Of course, in addition to this, we will provide MSDS files.

Do you test ABCA3 protein products for endotoxin levels? 04/14/2023

We can detect and remove endotoxins from protein products upon request. Please consult our technical experts for specific services.

What physiological processes are ABCA3 proteins involved in? 04/14/2023

ABCA3 transporters may be involved in the development of resistance to xenobiotics and engulfment during programmed cell death.

Which protein family does ABCA3 protein belong to? 04/14/2023

ABCA3 is a member of the superfamily of ATP-binding cassette (ABC) transporters and a member of the ABC1 subfamily.

Can you provide ABCA3 proteins from other species besides humans and mice? 04/14/2023

Our experts can perform customized protein expression according to the research needs of our customers.

Why does your ABCA3 protein use His and GST tags? 04/14/2023

His and GST tags are commonly used for purification and are beneficial for improving protein solubility and downstream applications.

What are your recombinant ABCA3 hosts? 04/14/2023

Our recombinant ABCA3 proteins are expressed from E. coli and mammalian cells.

Does ABCA3 correlate with lung health and disease? 04/14/2023

ABCA3 is a highly conserved transmembrane protein that plays a key role in regulating pulmonary surfactant homeostasis, and mutations in this protein have been increasingly recognized as a cause of inherited lung disease.

Customer Reviews (3)

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Reviews
08/12/2022

    Creative BioMart's technical experts are very professional, quick and friendly.

    06/13/2020

      I used recombinant ABCA3 protein as a positive control for WB, and the experiment worked well.

      02/14/2020

        Creative BioMart's recombinant proteins are highly pure and immunoreactivity, making them ideal for assays based on antigen-antibody reactions.

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