ABCC3

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ABCC3

Official Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Synonyms ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; cMOAT2; EST90757; MLP2; MOAT D; MRP3; ABC 31; ABC31; ABCC 3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; ATP-binding cassette sub-family C member 3; Canicular multispecific organic anion transporter; CMOAT 2; MLP 2; MOAT-D; MOATD; MRP 3; MRP3_HUMAN; Multi specific organic anion transporter D; Multi-specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multidrug resistance-associated protein 3; Multispecific organic anion tranporter D; OTTHUMP00000221667; OTTHUMP00000221668; OTTHUMP00000221670; multi-specific orga
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCC3-8118H Recombinant Human ABCC3 protein, His & T7-tagged E.coli His/T7
    Human ABCC3-9150HCL Recombinant Human ABCC3 293 Cell Lysate HEK293 N/A
    Mouse ABCC3-1101M Recombinant Mouse ABCC3 Protein Mammalian Cell His
    Rat ABCC3-405R Recombinant Rat ABCC3 Protein Mammalian Cell His

    ABCC3 involved in several pathways and played different roles in them. We selected most pathways ABCC3 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCC10; ABCA4; ABCA13; ABCB10; ABCC2; ABCB3L1; ABCA8; ABCB1; ABCC4; TAP2
    Bile secretion Slc4a2; ATP1A2; SLCO1A4; ATP1A1; OSTA; CYP7A1; SLC9A3; SLC4A4; ADCY3; SLC51A

    ABCC3 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC3 itself. We selected most functions ABCC3 had, and list some proteins which have the same functions with ABCC3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CSNK1G3; MAT2AB; MAP3K6; MLKL; HLCS; ABCD2; P2RX4B; CHKB; STK32A; CTPS1A
    ATPase activity, coupled to transmembrane movement of substances ABCA8; ABCA3; ABCG2A; DPY19L2; ABCD1; ABCA1; ABCD3; ABCB10; ABCG5; ABCA6
    organic anion transmembrane transporter activity SLC17A3; ABCC11; SLC22A31; SLCO4C1; SLCO1B2; SLC22A23; ABCC3; SLC22A7B.1; SLCO1A2; SLCO1A5

    ABCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC3.

    MLH1; ubiF; q81sm8_bacan; q8czu9_yerpe; tadA

    Cheng, Y; Xu, J; et al. Circulating autoantibody to ABCC3 may be a potential biomarker for esophageal squamous cell carcinoma. CLINICAL & TRANSLATIONAL ONCOLOGY 15:398-402(2013).
    Liu, LL; Liu, NA; et al. Are circulating autoantibodies to ABCC3 transporter a potential biomarker for lung cancer?. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 138:1737-1742(2012).

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