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Recombinant Human ABCC3 protein, His & T7-tagged

Cat.No. : ABCC3-8118H
Product Overview : Recombinant Human ABCC3 aa. (Phe1291~Asp1523 (Accession # O15438)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.5kDa.
Protein length : Phe1291~Asp1523 (Accession # O15438)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Characteristic : The isoelectric point is 5.7.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : ABCC3 ATP binding cassette subfamily C member 3 [ Homo sapiens (human) ]
Official Symbol : ABCC3
Gene ID : 8714
mRNA Refseq : NM_001144070.1
Protein Refseq : NP_001137542.1
UniProt ID : O15438

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Can ABCC3 be used as a biomarker for cancer treatment? 11/19/2022

Need more evidence. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers.

Does ABCC3 inhibition slows tumour progression? 10/08/2022

Not all the tumour.Some research shows that pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

What protein can regulate ABCC3 in PDAC? 08/09/2022

ABCC3 expression is regulated by mutant p53 via miR-34 and that the transporter drives PDAC progression via transport of the bioactive lipid lysophosphatidylinositol (LPI)

Which proteins interact with ABCC3 01/09/2022

Lots of proteins interact with ABCC3. Such as proteins involved in transport and metabolism,ABCB1 (P-glycoprotein) and ABCG2

The Role of ABCC3 Expression in Resistance of Ovarian Cancer 12/29/2021

ABCC3 was overexpressed in EOC tumors, but after the treatment with taxanes, its up-regulation disappeared.

Can ABCC3 be a cancer treatment target 10/05/2021

ABCC3 has been found highly expressed in different types of cancers and is associated with poor prognosis and resistance to treatments. Some researchs provide evidences that place ABCC3 as a potential therapeutic target for improving the cancer treatment.

What is the structure of ABCC3? Do you have crystal structure result? 09/15/2021

The crystal structure of ABCC3 has not yet been determined. However, there have been studies using cryo-electron microscopy (cryo-EM) to determine the structure of ABCC3 in complex with various ligands, such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)glutathione (DNP-SG).

What is the relationship between the expression of ABCC3 in glioma tissue and the degree of tumor development? 04/09/2021

The expression level of the ABCC3 gene in glioma tissues was lower than that of corresponding normal brain tissues.The overall survival and disease-free survival of in the ABCC3 low-expression group was significant decreased.

What are the inhibitors of ABCC3? 07/21/2020

MK571,Probenecid,Cepharanthine,Quinoline-based compounds

What's the functions of ABCC3 09/07/2019

Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.

Which signal pathways regulate the expression of ABCC3? 09/07/2018

Different cells and functions participate in different signal pathways. For example,Wnt signaling represses ABCC3 expression during colon carcinogenesis.

Is ABCC3 normally expressed in breast cancer cells? 08/09/2017

ABCC3 is frequently amplified and overexpressed in HER2-positive breast cancer.

Which transporters are associated with colon cancer? 04/06/2017

The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis.

Can ABCC3 transport cephalosporins? 06/17/2015

Not sure,need more evidence.Some result shows that intestinal absorption of cefadroxil depends partly on ABCC3 and ABCC4.

Customer Reviews (3)

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Reviews
02/01/2023

    Gifts with goods are very practical

    08/06/2022

      Good repeatability of experimental results

      04/09/2021

        High purity, good

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