Recombinant Human ABCC3 protein, His & T7-tagged
Cat.No. : | ABCC3-8118H |
Product Overview : | Recombinant Human ABCC3 aa. (Phe1291~Asp1523 (Accession # O15438)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 29.5kDa. |
Protein length : | Phe1291~Asp1523 (Accession # O15438) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >90% |
Characteristic : | The isoelectric point is 5.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage Buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | ABCC3 ATP binding cassette subfamily C member 3 [ Homo sapiens (human) ] |
Official Symbol : | ABCC3 |
Gene ID : | 8714 |
mRNA Refseq : | NM_001144070.1 |
Protein Refseq : | NP_001137542.1 |
UniProt ID : | O15438 |
Products Types
◆ Recombinant Protein | ||
ABCC3-60R | Recombinant Rat ABCC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCC3-2466H | Recombinant Human ABCC3 protein(871-950 aa), C-His-tagged | +Inquiry |
ABCC3-198M | Recombinant Mouse ABCC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCC3-405R | Recombinant Rat ABCC3 Protein | +Inquiry |
ABCC3-0440H | Recombinant Human ABCC3 Protein (Phe1291-Asp1523), N-His-tagged | +Inquiry |
◆ Lysates | ||
ABCC3-9150HCL | Recombinant Human ABCC3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionNeed more evidence. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers.
Not all the tumour.Some research shows that pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.
ABCC3 expression is regulated by mutant p53 via miR-34 and that the transporter drives PDAC progression via transport of the bioactive lipid lysophosphatidylinositol (LPI)
Lots of proteins interact with ABCC3. Such as proteins involved in transport and metabolism,ABCB1 (P-glycoprotein) and ABCG2
ABCC3 was overexpressed in EOC tumors, but after the treatment with taxanes, its up-regulation disappeared.
ABCC3 has been found highly expressed in different types of cancers and is associated with poor prognosis and resistance to treatments. Some researchs provide evidences that place ABCC3 as a potential therapeutic target for improving the cancer treatment.
The crystal structure of ABCC3 has not yet been determined. However, there have been studies using cryo-electron microscopy (cryo-EM) to determine the structure of ABCC3 in complex with various ligands, such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)glutathione (DNP-SG).
The expression level of the ABCC3 gene in glioma tissues was lower than that of corresponding normal brain tissues.The overall survival and disease-free survival of in the ABCC3 low-expression group was significant decreased.
MK571,Probenecid,Cepharanthine,Quinoline-based compounds
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
Different cells and functions participate in different signal pathways. For example,Wnt signaling represses ABCC3 expression during colon carcinogenesis.
ABCC3 is frequently amplified and overexpressed in HER2-positive breast cancer.
The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis.
Not sure,need more evidence.Some result shows that intestinal absorption of cefadroxil depends partly on ABCC3 and ABCC4.
Customer Reviews (3)
Write a reviewGifts with goods are very practical
Good repeatability of experimental results
High purity, good
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