ABCC4
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
ABCC4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; MRP4; MOATB; MOAT-B; EST170205; multidrug resistance-associated protein 4; MRP/cMOAT-related ABC transporter; multispecific organic anion transporter B; ATP-binding cassette sub-family C member 4; multi-specific organic anion transporter B; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily);
- Recombinant Proteins
- Chicken
- Human
- Zebrafish
- E.coli
- Mammalian cell
- Mammalian Cell
- Wheat Germ
- eGFP, Strep II,10His
- GST
- His
- His|T7
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCC4-8119H | Recombinant Human ABCC4 protein, His & T7-tagged | E.coli | His/T7 | Ile1041~Gln1274 (Accession # O15439) |
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| Human | ABCC4-048H | Recombinant Human ABCC4 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ABCC4-0103H | Recombinant Human ABCC4 Protein (M1-L1325), eGFP, Strep II, 10×His tagged | Mammalian cell | eGFP, Strep II,10His | M1-L1325 |
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| Human | ABCC4-0492H | Recombinant Human ABCC4 Protein (Ile1041-Gln1274), N-His-tagged | E.coli | N-His | Ile1041-Gln1274 |
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| Human | ABCC4-0104H | Recombinant Human ABCC4 Protein (M1-L1325), eGFP, Strep II, 10×His tagged | Mammalian cell | eGFP, Strep II,10His | M1-L1325 |
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| Zebrafish | ABCC4-1621Z | Recombinant Zebrafish ABCC4 | Mammalian Cell | His |
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| Chicken | ABCC4-2515C | Recombinant Chicken ABCC4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCC4 Related Articles
- ABCC4 Related Research Area
ABCC4 involved in several pathways and played different roles in them. We selected most pathways ABCC4 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | Abcb1b;ABCC2;CFTR;ABCB10;ABCC10;ABCC5;SUR2A;ABCB3L1;ABCG3 |
ABCC4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC4 itself. We selected most functions ABCC4 had, and list some proteins which have the same functions with ABCC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
ABCC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC4.
- Q&As
- Reviews
Q&As (15)
Ask a questionABCC4 is required for cell proliferation and tumorigenesis in non-small cell lung cancer. The percentage of cells in G1 phase was increased when ABCC4 expression was suppressed.
Study show that ABCC4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
Cancer,inflammatory bowel disease,Cardiovascular disease,Neurological disorders and so on.
Specific for different ABCC protein, may reduced growth, migration and invasion.
cAMP/Epac-PKA pathway,MEK/ERK or PI3K/AKT signaling pathway, depends on different functions.
MRP4/ABCC4 is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells.
Some results show that MRP4 (ABCC4) is a potential pharmacologic target for cardiovascular disease.
ABCC4 is capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell, such as cyclic nucleotides, eicosanoids, urate and conjugated steroids.
MK571 or sorafenib, as well as after ABCC4 siRNA
Yes, MRP4 or ABCC4 that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions.
The protein is composed of 1,522 amino acids and has a predicted molecular weight of approximately 171 kDa.But the crystal structure of MRP4 has not yet been determined.
One research show that miR-124a and miR-506 expression was negatively correlated with MRP4 protein expression in 26 human kidney samples.
ABCC4 is primarily expressed on the plasma membrane. The ABCC4 membrane transporter modulates platelet aggregation
Yes, a previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ABCC4 gene in most European populations.
A prolonged inhibition of MRP4 can promote cardiac hypertrophy, and MRP4 inhibition in platelets induces a moderate thrombopathy.
Customer Reviews (3)
Write a reviewIt's good for immune test
Nice Protein
Natural protein concentration is very high
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