ABCF1
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Official Full Name
ATP-binding cassette, sub-family F (GCN20), member 1
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. -
Synonyms
ABCF1; ATP-binding cassette, sub-family F (GCN20), member 1; ABC50; ATP-binding cassette sub-family F member 1; EST123147; TNF-alpha-stimulated ABC protein; TNFalpha-inducible ATP-binding protein; ATP-binding cassette 50 (TNF-alpha stimulated); ABC27;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ABCF1 involved in several pathways and played different roles in them. We selected most pathways ABCF1 participated on our site, such as ABC-family proteins mediated transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABC-family proteins mediated transport | EIF2S1;EIF2S1A;CFTR;ABCA4A;APOA1B;ABCA8;ABCB8;KCNJ11;ABCF1 |
Transmembrane transport of small molecules | SLC7A11;TTYH3B;PIP;AQP1A.2;SLC6A6A;SLC9A5;TPCN1;SLC6A20B;SLC43A1B |
ABCF1 has several biochemical functions, for example, ATP binding, ATPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCF1 itself. We selected most functions ABCF1 had, and list some proteins which have the same functions with ABCF1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | NLRC4;MERTK;LIMK1;PRPS2;DNAH11;FIGN;KIF3B;GNE;CHD2 |
ATPase activity | SMARCA4A;KIF3CB;MYH8;PSMC6;CLPX;ACTC1;RHOBTB3;ABCF2;KIF20B |
poly(A) RNA binding | HMGN2;XRN2;YTHDF1;NGDN;BRIX1;RALY;NOL7;MRPL39;HSPE1 |
protein binding | SOX4;GADD45G;OPRM1;TRPC4;CACNG2;C12orf68;RNF168;MYOC;HIST1H4C |
ribosome binding | MTOR;BAG6;CPEB1B;SBDS;IGHMBP2;EIF5A2;EIF2S1B;CPEB1;NARG1 |
translation activator activity | PABPC1;BOLL;PAIP1;LARP1;DAZL;ABCF1;RPS27L |
translation factor activity, RNA binding | PPP1R2P9;EEF1D;EIF4G3;GTF2H2;CPEB1A;EIF1AX;CPEB3;GTF2H3;EEF1A2 |
ABCF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCF1.
SRPK1; PINX1; LYAR; PRKAB1; ITGB3BP; CNOT1; ere_dna; NOP56; EED; FN1; Fbl; HDGF; SNW1; EMC2; IFI16; TIGD6; CDC5L
- Q&As
- Reviews
Q&As (20)
Ask a questionIt is possible that genetic variations, such as single nucleotide polymorphisms (SNPs) or epigenetic modifications, could potentially impact ABCF1 expression or function.
The ABC domain is involved in ATP binding and hydrolysis, which provides the energy required for ABCF1's function in translation initiation. The NBDs are essential for the interaction of ABCF1 with other proteins and RNA molecules involved in translation initiation.
It is expected that disruption of ABCF1 function could lead to defects in translation initiation and potentially impact overall protein synthesis.
Yes, ABCF1 does play a role in protein synthesis and translation regulation. It is involved in the scanning process during translation initiation, ensuring accurate selection of the start codon and proper assembly of the translation initiation complex
The cellular function of ABCF1 is associated with its involvement in translation initiation. It participates in the scanning process of ribosomes during translation initiation, ensuring the selection of the appropriate start codon on mRNA and facilitating the assembly of the translation initiation complex
ABCF1 may be dysregulated or aberrantly expressed in certain cancers, including breast cancer and gastric cancer.
ABCF1 is generally expressed in various tissues and cell types, suggesting a broad expression profile.
Given its role in translation initiation, it is possible that dysregulation of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation
It is plausible that cellular signaling pathways involved in translation regulation, stress responses, or other cellular processes could potentially modulate ABCF1 activity.
It is plausible that post-translational modifications such as phosphorylation, acetylation, or ubiquitination could potentially regulate ABCF1. These modifications might influence its interaction with other proteins or RNA molecules, or impact its localization or activity.
The structural features or domains of ABCF1 that contribute to its function in translation initiation include the ATP-binding cassette (ABC) domain and the nucleotide-binding domains (NBDs)
Given its role in translation initiation, it is possible that dysregulation or malfunction of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation
It is likely that post-translational modifications, protein-protein interactions, and potential signaling pathways could influence ABCF1 activity or its subcellular localization.
Knockout mouse models, such as ABCF1-deficient mice, have been generated to investigate the physiological role of ABCF1 in vivo
ABCF1's involvement in specialized translation processes, such as translation of specific subsets of mRNAs.
It interacts with eukaryotic initiation factors, such as eIF3, and is also associated with other proteins in the translation initiation complex. These interactions contribute to the regulation and coordination of translation initiation processes.
stress granules are dynamic cytoplasmic aggregates that form during cellular stress, and as ABCF1 is involved in translation initiation, it is possible that it could play a role in stress granule formation or regulation in response to certain stress conditions.
ABCF1 has been shown to interact with RNA molecules, particularly during translation initiation. It interacts with specific regions of mRNA, including the 5' untranslated region (UTR), facilitating the scanning process of ribosomes during translation initiation.
It is known to be predominantly localized in the cytoplasm, possibly associated with ribosomes. The presence of certain localization signals or interacting proteins may contribute to its subcellular distribution
Cell culture systems, including both primary cells and established cell lines, are commonly used to study the molecular mechanisms and functional consequences of ABCF1 manipulation.
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