ACSL5
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Official Full Name
acyl-CoA synthetase long-chain family member 5
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Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
ACSL5; acyl-CoA synthetase long-chain family member 5; FACL5, fatty acid Coenzyme A ligase, long chain 5; long-chain-fatty-acid--CoA ligase 5; ACS2; ACS5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase; long chain 5; long chain ac;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACSL5 Related Articles
ACSL5 involved in several pathways and played different roles in them. We selected most pathways ACSL5 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid biosynthesis | MCAT;ACSL1A;ECHDC2;ACSL3A;ACSL1B;OXSM;ACAA2;ACSBG1;ACSL4 |
Fatty acid degradation | ACSL3B;ACOX3;ALDH3A2A;ACAA2;ADH2-2;ACADM;HADHAA;ADH5;CPT1A |
Metabolic pathways | ALDH1A3;UGT2A1;GCSHA;UROD;ACADVL;GANAB;PAPSS2B;CMPK;XDH |
Fatty acid metabolism | ACOX1;TECR;ACADM;PTPLAD1;CPT1B;SCDB;OXSM;HADHB;ACSL4 |
PPAR signaling pathway | ACSBG2;ACOX1;FABP1;ACSL4A;FABP7A;PPARDB;PDPK1;DBI;SLC27A2 |
Peroxisome | DAO.1;PEX10;HAO2;CRATA;PEX26;ABCD2;HAO1;PIPOX;ECI2 |
Adipocytokine signaling pathway | STK11;CPT1B;POMC;CPT1C;ACSL1;RXRB;AKT2;JAK2;PTPN11A |
ACSL5 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL5 itself. We selected most functions ACSL5 had, and list some proteins which have the same functions with ACSL5. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | PAPSS1;SRR;MAP4K5;CKB;AK9;VWA8;ATAD1A;XRCC6;STK24A |
long-chain fatty acid-CoA ligase activity | SLC27A3;SLC27A5;SLC27A4;SLC27A1A;ACSL5;ACSL1;ACSBG1;SLC27A2;ACSBG2 |
ACSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL5.
CREB3; ogl; LRRK2
- Q&As
- Reviews
Q&As (10)
Ask a questionStudies have shown that increased ACSL5 expression in adipose tissue is associated with decreased insulin sensitivity and increased risk of developing type 2 diabetes.
ACSL5 is involved in the production of pro-inflammatory cytokines in macrophages, which play a critical role in the development of inflammation.
ACSL5 expression has been shown to contribute to drug resistance in cancer cells, and its inhibition may enhance the efficacy of chemotherapy drugs.
ACSL5 is involved in the uptake and utilization of fatty acids in various tissues, including the liver, adipose tissue, and muscle.
ACSL5 is involved in the regulation of cell signaling pathways, including the PI3K-Akt and mTOR pathways, which play critical roles in cell growth and survival.
ACSL5 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.
Studies have shown that ACSL5 gene expression is upregulated in various cancers, including breast cancer, and it is involved in tumor growth and survival.
ACSL5 is involved in the storage and mobilization of fatty acids in adipose tissue, which plays a critical role in regulating energy balance.
The ACSL5 protein consists of three domains: an N-terminal domain, a central AMP-binding domain, and a C-terminal acyl-CoA synthetase domain.
Studies have shown that increased ACSL5 expression in the liver is associated with fatty liver disease, which is characterized by the accumulation of fat in the liver.
Customer Reviews (5)
Write a reviewVery impressed.
If you want a protein that's as smooth as butter, look no further. This one's the cream of the crop.
My analysis of the protein revealed that it retained its enzymatic activity, indicating proper folding and function.
I've tried several recombinant proteins before, but this one stands out. The quality was outstanding, and the yield was impressive. It saved me a lot of time in my research. Definitely worth every penny!
The customer support was also excellent, providing prompt assistance when needed.
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