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ACSL5

  • Official Full Name

    acyl-CoA synthetase long-chain family member 5

  • Overview

    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms

    ACSL5; acyl-CoA synthetase long-chain family member 5; FACL5, fatty acid Coenzyme A ligase, long chain 5; long-chain-fatty-acid--CoA ligase 5; ACS2; ACS5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase; long chain 5; long chain ac;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACSL5-200H Recombinant Human ACSL5 Protein, GST-tagged Wheat Germ GST
Human ACSL5-201H Recombinant Human ACSL5 Protein, GST-tagged Wheat Germ GST
Human ACSL5-9073HCL Recombinant Human ACSL5 293 Cell Lysate HEK293 N/A
Human ACSL5-4026H Recombinant Human ACSL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACSL5-1924H Recombinant Human ACSL5 Protein (33-683 aa), His-tagged E.coli His 33-683 aa
Human ACSL5-804HF Recombinant Full Length Human ACSL5 Protein, GST-tagged In Vitro Cell Free System GST 739 amino acids
Human ACSL5-57H Recombinant Human ACSL5 Protein, His-tagged E.coli N-His Arg432-Asp683
Human ACSL5-1849HFL Recombinant Full Length Human ACSL5 Protein, C-Flag-tagged Mammalian cells Flag
Human ACSL5-1593H Recombinant Human ACSL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACSL5-262H Recombinant Human ACSL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACSL5-262H-B Recombinant Human ACSL5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Acsl5-58M Recombinant Mouse Acsl5 Protein, His-tagged E.coli N-His Ile390-Glu683
Mouse Acsl5-1508M Recombinant Mouse Acsl5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ACSL5-472R Recombinant Rat ACSL5 Protein Mammalian Cell His
Rat ACSL5-128R-B Recombinant Rat ACSL5 Protein Pre-coupled Magnetic Beads HEK293
Rat ACSL5-128R Recombinant Rat ACSL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rattus norvegicus (Rat) RFL-23345RF Recombinant Full Length Rat Long-Chain-Fatty-Acid--Coa Ligase 5(Acsl5) Protein, His-Tagged E.coli expression system His Full Length (1-683)
Zebrafish ACSL5-1319Z Recombinant Zebrafish ACSL5 Mammalian Cell His
Chicken ACSL5-2897C Recombinant Chicken ACSL5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACSL5 Related Articles

ACSL5 involved in several pathways and played different roles in them. We selected most pathways ACSL5 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid biosynthesisMCAT;ACSL1A;ECHDC2;ACSL3A;ACSL1B;OXSM;ACAA2;ACSBG1;ACSL4
Fatty acid degradationACSL3B;ACOX3;ALDH3A2A;ACAA2;ADH2-2;ACADM;HADHAA;ADH5;CPT1A
Metabolic pathwaysALDH1A3;UGT2A1;GCSHA;UROD;ACADVL;GANAB;PAPSS2B;CMPK;XDH
Fatty acid metabolismACOX1;TECR;ACADM;PTPLAD1;CPT1B;SCDB;OXSM;HADHB;ACSL4
PPAR signaling pathwayACSBG2;ACOX1;FABP1;ACSL4A;FABP7A;PPARDB;PDPK1;DBI;SLC27A2
PeroxisomeDAO.1;PEX10;HAO2;CRATA;PEX26;ABCD2;HAO1;PIPOX;ECI2
Adipocytokine signaling pathwaySTK11;CPT1B;POMC;CPT1C;ACSL1;RXRB;AKT2;JAK2;PTPN11A

ACSL5 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL5 itself. We selected most functions ACSL5 had, and list some proteins which have the same functions with ACSL5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPAPSS1;SRR;MAP4K5;CKB;AK9;VWA8;ATAD1A;XRCC6;STK24A
long-chain fatty acid-CoA ligase activitySLC27A3;SLC27A5;SLC27A4;SLC27A1A;ACSL5;ACSL1;ACSBG1;SLC27A2;ACSBG2

ACSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL5.

CREB3; ogl; LRRK2

Saatchi, M; Beever, JE; et al. QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies. BMC GENOMICS 15:-(2014).
Wang, S; Matthan, NR; et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in Mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. CLINICAL NUTRITION 33:260-266(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does ACSL5 affect insulin sensitivity? 07/19/2022

Studies have shown that increased ACSL5 expression in adipose tissue is associated with decreased insulin sensitivity and increased risk of developing type 2 diabetes.

How is ACSL5 involved in inflammation? 06/10/2021

ACSL5 is involved in the production of pro-inflammatory cytokines in macrophages, which play a critical role in the development of inflammation.

What is the role of ACSL5 in drug resistance? 05/22/2021

ACSL5 expression has been shown to contribute to drug resistance in cancer cells, and its inhibition may enhance the efficacy of chemotherapy drugs.

What is the role of ACSL5 in lipid metabolism? 04/11/2021

ACSL5 is involved in the uptake and utilization of fatty acids in various tissues, including the liver, adipose tissue, and muscle.

How is ACSL5 involved in cell signaling? 09/15/2020

ACSL5 is involved in the regulation of cell signaling pathways, including the PI3K-Akt and mTOR pathways, which play critical roles in cell growth and survival.

How is ACSL5 gene expression regulated? 06/20/2020

ACSL5 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.

What is the role of ACSL5 gene in cancer? 06/01/2020

Studies have shown that ACSL5 gene expression is upregulated in various cancers, including breast cancer, and it is involved in tumor growth and survival.

What is the function of ACSL5 in adipose tissue? 03/12/2020

ACSL5 is involved in the storage and mobilization of fatty acids in adipose tissue, which plays a critical role in regulating energy balance.

What is the structure of the ACSL5 protein? 01/13/2020

The ACSL5 protein consists of three domains: an N-terminal domain, a central AMP-binding domain, and a C-terminal acyl-CoA synthetase domain.

What is the relationship between ACSL5 and fatty liver disease? 10/14/2019

Studies have shown that increased ACSL5 expression in the liver is associated with fatty liver disease, which is characterized by the accumulation of fat in the liver.

Customer Reviews (5)

Write a review
Reviews
05/10/2021

    Very impressed.

    04/01/2020

      If you want a protein that's as smooth as butter, look no further. This one's the cream of the crop.

      02/10/2020

        My analysis of the protein revealed that it retained its enzymatic activity, indicating proper folding and function.

        01/23/2019

          I've tried several recombinant proteins before, but this one stands out. The quality was outstanding, and the yield was impressive. It saved me a lot of time in my research. Definitely worth every penny!

          01/15/2019

            The customer support was also excellent, providing prompt assistance when needed.

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