ACSL5

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ACSL5

Official Full Name acyl-CoA synthetase long-chain family member 5
Background The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms ACSL5; acyl-CoA synthetase long-chain family member 5; FACL5, fatty acid Coenzyme A ligase, long chain 5; long-chain-fatty-acid--CoA ligase 5; ACS2; ACS5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase; long chain 5; long chain ac
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Acsl5-1508M Recombinant Mouse Acsl5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ACSL5-1593H Recombinant Human ACSL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACSL5-1924H Recombinant Human ACSL5 Protein (33-683 aa), His-tagged E.coli His
    Human ACSL5-4026H Recombinant Human ACSL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACSL5-200H Recombinant Human ACSL5 Protein, GST-tagged Wheat Germ GST
    Human ACSL5-201H Recombinant Human ACSL5 Protein, GST-tagged Wheat Germ GST
    Human ACSL5-9073HCL Recombinant Human ACSL5 293 Cell Lysate HEK293 N/A
    Rat ACSL5-472R Recombinant Rat ACSL5 Protein Mammalian Cell His
    Chicken ACSL5-2897C Recombinant Chicken ACSL5 Mammalian Cell His
    Zebrafish ACSL5-1319Z Recombinant Zebrafish ACSL5 Mammalian Cell His

    ACSL5 involved in several pathways and played different roles in them. We selected most pathways ACSL5 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid biosynthesis ACSL1A; ACSL1; ECHDC2; ACSL4; ACACA; DECR1; MCAT; ACSL5; ACSL3; ACSL3A
    Fatty acid degradation ADH1; CYP4A11; ADH1A; ACADL; CYP4A10; ACADSB; ECI1; ACSL1; ALDH3A2; ACSL4
    Metabolic pathways GFPT1; MINPP1A; FUT8A; ST3GAL3B; ALDH5A1; GCNT4; PNPO; ADI1; XYLT1; SAT1A.1
    Fatty acid metabolism ACADS; FADS2; ACSL5; CPT1A; HSD17B12; MECR; ACOX3; PTPLAD1; MCAT; ACADL
    PPAR signaling pathway FABP1A; FABP4; ACSL4; HMGCS2; ACSL4B; UBC; ACOX3; ADIPOQ; PCK1; CYP8B1
    Peroxisome IDH2; PRDX5; NOS2; CROT; PEX5L; SLC25A17; PEX11B; ACOX2; DAO.1; PMVK
    Adipocytokine signaling pathway LEPR; AKT3A; PRKAG3B; ADIPOQ; RXRGB; ACSL4A; CD36; CAMKK1; ACACB; ADIPOR1B

    ACSL5 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL5 itself. We selected most functions ACSL5 had, and list some proteins which have the same functions with ACSL5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ENTPD8; MOV10B.1; PKM2; ACTR3B; MAPK4; FGFR2; PAPD4; SMARCAL1; MAP3K9; PIKFYVE
    long-chain fatty acid-CoA ligase activity ACSL5; ACSBG1; SLC27A5; SLC27A3; SLC27A2; SLC27A1A; ACSL4; SLC27A1B; SLC27A4; ACSBG2

    ACSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL5.

    CREB3; ogl; LRRK2

    Saatchi, M; Beever, JE; et al. QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies. BMC GENOMICS 15:-(2014).
    Wang, S; Matthan, NR; et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in Mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. CLINICAL NUTRITION 33:260-266(2014).

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