Recombinant Human ACSL5 Protein, GST-tagged
Cat.No. : | ACSL5-200H |
Product Overview : | Human ACSL5 full-length ORF ( NP_057318.2, 1 a.a. - 739 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 108.7 kDa |
AA Sequence : | MDALKPPCLWRNHERGKKDRDSCGR KNSEPGSPHSLEALRDAAPSQGLNF LLLFTKMLFIFNFLFSPLPTPALIC ILTFGAAIFLWLITRPQPVLPLLDL NNQSVGIEGGARKGVSQKNNDLTSC CFSDAKTMYEVFQRGLAVSDNGPCL GYRKPNQPYRWLSYKQVSDRAEYLG SCLLHKGYKSSPDQFVGIFAQNRPE WIISELACYTYSMVAVPLYDTLGPE AIVHIVNKADIAMVICDTPQKALVL IGNVEKGFTPSLKVIILMDPFDDDL KQRGEKSGIEILSLYDAENLGKEHF RKPVPPSPEDLSVICFTSGTTGDPK GAMITHQNIVSNAAAFLKCVEHAYE PTPDDVAISYLPLAHMFERIVQAVV YSCGARVGFFQGDIRLLADDMKTLK PTLFPAVPRLLNRIYDKVQNEAKTP LKKFLLKLAVSSKFKELQKGIIRHD SFWDKLIFAKIQDSLGGRVRVIVTG AAPMSTSVMTFFRAAMGCQVYEAYG QTECTGGCTFTLPGDWTSGHVGVPL ACNYVKLEDVADMNYFTVNNEGEVC IKGTNVFKGYLKDPEKTQEALDSDG WLHTGDIGRWLPNGTLKIIDRKKNI FKLAQGEYIAPEKIENIYNRSQPVL QIFVHGESLRSSLVGVVVPDTDVLP SFAAKLGVKGSFEELCQNQVVREAI LEDLQKIGKESGLKTFEQVKAIFLH PEPFSIENGLLTPTLKAKRGELSKY FRTQIDSLYEHIQD |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACSL5 acyl-CoA synthetase long-chain family member 5 [ Homo sapiens ] |
Official Symbol : | ACSL5 |
Synonyms : | ACSL5; acyl-CoA synthetase long-chain family member 5; FACL5, fatty acid Coenzyme A ligase, long chain 5; long-chain-fatty-acid--CoA ligase 5; ACS2; ACS5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase; long chain 5; long chain acyl CoA synthetase 5; long chain fatty acid coenzyme A ligase 5; LACS 5; fatty acid coenzyme A ligase 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5; FACL5; |
Gene ID : | 51703 |
mRNA Refseq : | NM_016234 |
Protein Refseq : | NP_057318 |
MIM : | 605677 |
UniProt ID : | Q9ULC5 |
Products Types
◆ Recombinant Protein | ||
ACSL5-128R | Recombinant Rat ACSL5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Acsl5-1508M | Recombinant Mouse Acsl5 Protein, Myc/DDK-tagged | +Inquiry |
Acsl5-58M | Recombinant Mouse Acsl5 Protein, His-tagged | +Inquiry |
ACSL5-57H | Recombinant Human ACSL5 Protein, His-tagged | +Inquiry |
ACSL5-1924H | Recombinant Human ACSL5 Protein (33-683 aa), His-tagged | +Inquiry |
◆ Lysates | ||
ACSL5-9073HCL | Recombinant Human ACSL5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionStudies have shown that increased ACSL5 expression in adipose tissue is associated with decreased insulin sensitivity and increased risk of developing type 2 diabetes.
ACSL5 is involved in the production of pro-inflammatory cytokines in macrophages, which play a critical role in the development of inflammation.
ACSL5 expression has been shown to contribute to drug resistance in cancer cells, and its inhibition may enhance the efficacy of chemotherapy drugs.
ACSL5 is involved in the uptake and utilization of fatty acids in various tissues, including the liver, adipose tissue, and muscle.
ACSL5 is involved in the regulation of cell signaling pathways, including the PI3K-Akt and mTOR pathways, which play critical roles in cell growth and survival.
ACSL5 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.
Studies have shown that ACSL5 gene expression is upregulated in various cancers, including breast cancer, and it is involved in tumor growth and survival.
ACSL5 is involved in the storage and mobilization of fatty acids in adipose tissue, which plays a critical role in regulating energy balance.
The ACSL5 protein consists of three domains: an N-terminal domain, a central AMP-binding domain, and a C-terminal acyl-CoA synthetase domain.
Studies have shown that increased ACSL5 expression in the liver is associated with fatty liver disease, which is characterized by the accumulation of fat in the liver.
Customer Reviews (5)
Write a reviewVery impressed.
If you want a protein that's as smooth as butter, look no further. This one's the cream of the crop.
My analysis of the protein revealed that it retained its enzymatic activity, indicating proper folding and function.
I've tried several recombinant proteins before, but this one stands out. The quality was outstanding, and the yield was impressive. It saved me a lot of time in my research. Definitely worth every penny!
The customer support was also excellent, providing prompt assistance when needed.
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