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Recombinant Human ACSL5 Protein, GST-tagged

Cat.No. : ACSL5-200H
Product Overview : Human ACSL5 full-length ORF ( NP_057318.2, 1 a.a. - 739 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 108.7 kDa
AA Sequence : MDALKPPCLWRNHERGKKDRDSCGR KNSEPGSPHSLEALRDAAPSQGLNF LLLFTKMLFIFNFLFSPLPTPALIC ILTFGAAIFLWLITRPQPVLPLLDL NNQSVGIEGGARKGVSQKNNDLTSC CFSDAKTMYEVFQRGLAVSDNGPCL GYRKPNQPYRWLSYKQVSDRAEYLG SCLLHKGYKSSPDQFVGIFAQNRPE WIISELACYTYSMVAVPLYDTLGPE AIVHIVNKADIAMVICDTPQKALVL IGNVEKGFTPSLKVIILMDPFDDDL KQRGEKSGIEILSLYDAENLGKEHF RKPVPPSPEDLSVICFTSGTTGDPK GAMITHQNIVSNAAAFLKCVEHAYE PTPDDVAISYLPLAHMFERIVQAVV YSCGARVGFFQGDIRLLADDMKTLK PTLFPAVPRLLNRIYDKVQNEAKTP LKKFLLKLAVSSKFKELQKGIIRHD SFWDKLIFAKIQDSLGGRVRVIVTG AAPMSTSVMTFFRAAMGCQVYEAYG QTECTGGCTFTLPGDWTSGHVGVPL ACNYVKLEDVADMNYFTVNNEGEVC IKGTNVFKGYLKDPEKTQEALDSDG WLHTGDIGRWLPNGTLKIIDRKKNI FKLAQGEYIAPEKIENIYNRSQPVL QIFVHGESLRSSLVGVVVPDTDVLP SFAAKLGVKGSFEELCQNQVVREAI LEDLQKIGKESGLKTFEQVKAIFLH PEPFSIENGLLTPTLKAKRGELSKY FRTQIDSLYEHIQD
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ACSL5 acyl-CoA synthetase long-chain family member 5 [ Homo sapiens ]
Official Symbol : ACSL5
Synonyms : ACSL5; acyl-CoA synthetase long-chain family member 5; FACL5, fatty acid Coenzyme A ligase, long chain 5; long-chain-fatty-acid--CoA ligase 5; ACS2; ACS5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid Coenzyme A ligase; long chain 5; long chain acyl CoA synthetase 5; long chain fatty acid coenzyme A ligase 5; LACS 5; fatty acid coenzyme A ligase 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5; FACL5;
Gene ID : 51703
mRNA Refseq : NM_016234
Protein Refseq : NP_057318
MIM : 605677
UniProt ID : Q9ULC5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does ACSL5 affect insulin sensitivity? 07/19/2022

Studies have shown that increased ACSL5 expression in adipose tissue is associated with decreased insulin sensitivity and increased risk of developing type 2 diabetes.

How is ACSL5 involved in inflammation? 06/10/2021

ACSL5 is involved in the production of pro-inflammatory cytokines in macrophages, which play a critical role in the development of inflammation.

What is the role of ACSL5 in drug resistance? 05/22/2021

ACSL5 expression has been shown to contribute to drug resistance in cancer cells, and its inhibition may enhance the efficacy of chemotherapy drugs.

What is the role of ACSL5 in lipid metabolism? 04/11/2021

ACSL5 is involved in the uptake and utilization of fatty acids in various tissues, including the liver, adipose tissue, and muscle.

How is ACSL5 involved in cell signaling? 09/15/2020

ACSL5 is involved in the regulation of cell signaling pathways, including the PI3K-Akt and mTOR pathways, which play critical roles in cell growth and survival.

How is ACSL5 gene expression regulated? 06/20/2020

ACSL5 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.

What is the role of ACSL5 gene in cancer? 06/01/2020

Studies have shown that ACSL5 gene expression is upregulated in various cancers, including breast cancer, and it is involved in tumor growth and survival.

What is the function of ACSL5 in adipose tissue? 03/12/2020

ACSL5 is involved in the storage and mobilization of fatty acids in adipose tissue, which plays a critical role in regulating energy balance.

What is the structure of the ACSL5 protein? 01/13/2020

The ACSL5 protein consists of three domains: an N-terminal domain, a central AMP-binding domain, and a C-terminal acyl-CoA synthetase domain.

What is the relationship between ACSL5 and fatty liver disease? 10/14/2019

Studies have shown that increased ACSL5 expression in the liver is associated with fatty liver disease, which is characterized by the accumulation of fat in the liver.

Customer Reviews (5)

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Reviews
05/10/2021

    Very impressed.

    04/01/2020

      If you want a protein that's as smooth as butter, look no further. This one's the cream of the crop.

      02/10/2020

        My analysis of the protein revealed that it retained its enzymatic activity, indicating proper folding and function.

        01/23/2019

          I've tried several recombinant proteins before, but this one stands out. The quality was outstanding, and the yield was impressive. It saved me a lot of time in my research. Definitely worth every penny!

          01/15/2019

            The customer support was also excellent, providing prompt assistance when needed.

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