ADAM12
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Official Full Name
ADAM metallopeptidase domain 12 -
Overview
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014] -
Synonyms
ADAM12;ADAM metallopeptidase domain 12;MCMP;MLTN;CAR10;MLTNA;MCMPMltna;ADAM12-OT1;disintegrin and metalloproteinase domain-containing protein 12;meltrin-alpha;metalloprotease-disintegrin 12 transmembrane
Recombinant Proteins
- Human
- Mouse
- Chicken
- HEK293
- CHO
- Mammalian Cells
- E.coli
- Wheat Germ
- Human Cells
- Insect Cells
- In Vitro Cell Free System
- Mouse
- Rabbit
- His
- Non
- GST
- Myc
- Avi
- Fc
Involved Pathway
ADAM12 involved in several pathways and played different roles in them. We selected most pathways ADAM12 participated on our site, such as Notch signaling pathway,Signal Transduction,Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Syndecan-4-mediated signaling events | MDK,GIPC1 |
| Notch signaling pathway | SNW1,MFAP5,DLL4,ADAM17,HER12,JAG1B,MAML2,HES1,CTBP2,DTX3L |
| Signal Transduction | PROK2,RGS6,GPR31B,ADM,FSTL1A,TAGAP1,CUL5A,CSNK1G2,OXGR1A.3,ARHGAP40 |
| Signaling by EGFR | LRIG1,PAG1,PTPRK,SPRY1 |
Protein Function
ADAM12 has several biochemical functions, for example, SH3 domain binding,metalloendopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM12 itself. We selected most functions ADAM12 had, and list some proteins which have the same functions with ADAM12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallopeptidase activity | ADAMTS13,ADAMTS7,C6AST1,NAALADL1,CNDP2,XPNPEP2,ADAMTS5,ADAMTS9,ERAP2,HE1A |
| SH3 domain binding | SH3BGRL,USP8,CYBA,CRB3,INPP5D,ADAM10,DOCK4,PTTG2,ADAM17,PLSCR4 |
| metalloendopeptidase activity | ADAMTS15,THSD4,MMP2,ADAM15,ADAM20,ADAM5,ADAMTS3,MMP24,BMP1B,MMP13A |
| zinc ion binding | RBBP6,SRSF7B,RBM4,MORC2B,CNBP,RARG,RNF31,ATXN7L3,GFI1AA,NR2F5 |
| protein binding | HDAC9,DAPP1,CABP5,CASP2,CHN1,MAPKAPK3,VEGFAA,ATP5B,ATRX,SERPINI2 |
Interacting Protein
ADAM12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM12.
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References
- Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
- Kerna, I; Kisand, K; et al. The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. JOINT BONE SPINE 81:51-56(2014).
