adam12
Share
  • Official Full Name
  • ADAM metallopeptidase domain 12
  • Background
  • This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
  • Synonyms
  • ADAM12; ADAM metallopeptidase domain 12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane;
Cat.#:ADAM12-2594MTag:His|Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ADAM12 Protein (206-706 aa), His-Myc-tagged
+Inquiry
Cat.#:ADAM12-2799MTag:His|Myc
Source (Host):BaculovirusSpecies:Mouse
Product nameRecombinant Mouse ADAM12 Protein (206-706 aa), His-Myc-tagged
+Inquiry
Cat.#:ADAM12-365HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAM12 Protein, His-tagged
+Inquiry
Cat.#:ADAM12-216HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAM12, C13&N15-labeled
+Inquiry
Cat.#:ADAM12-2179HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAM12, His tagged
+Inquiry
Cat.#:ADAM12-233HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ADAM12, His-tagged
+Inquiry
Cat.#:ADAM12-274HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM12 Protein, GST-tagged
+Inquiry
Cat.#:ADAM12-1277MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAM12 Protein
+Inquiry
Cat.#:ADAM12-3898CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADAM12
+Inquiry
Cat.#:ADAM12-264HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform, His-tagged
+Inquiry
Cat.#:ADAM12-2592HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAM12 cell lysate
+Inquiry

Involved Pathway

ADAM12 involved in several pathways and played different roles in them. We selected most pathways ADAM12 participated on our site, such as Notch signaling pathway, Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
HDAC2; RBPJB; PSENEN; LFNG; APH1C; DTX4; DLC; RBPJL; HES1; MFAP2
Signal Transduction
GRAP; ARHGAP18; OPN1LW1; METAP2A; FAM13B; ARHGAP1; TAX1BP1B; CDON; SKILB; RAMP1
Signaling by EGFR
SPRY1; ADAM12; LRIG1; PTPRK; PAG1
Syndecan-4-mediated signaling events
ADAM12; MDK; GIPC1

Protein Function

ADAM12 has several biochemical functions, for example, SH3 domain binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM12 itself. We selected most functions ADAM12 had, and list some proteins which have the same functions with ADAM12. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein QKI; SH3BGRL; ITM2B; SOS1; FMN1; QK; HCLS1; ADAM17; SIRPA; DPYSL3
Function metalloendopeptidase activity
Related Protein ADAMTS1; ADAM1B; C6AST1; UQCRC2A; BMP1A; ADAM32; ADAM25; MMP8; ADAM18; MMP23B
Function metallopeptidase activity
Related Protein MMP2; ADAM23; TAF2; ACE; CLCA5; ADAMTS1; GM5136; ADAMTS13; ANPEPB; ECEL1
Function protein binding
Related Protein NAA35; DRD2; DGCR8; UBB; C2orf29; TGFBR1; ADIPOQ; CRBN; FREM2; OFCC1
Function zinc ion binding
Related Protein LIMD2; P2RX4; LIG3; SEC24C; PJA1; TK1; PGGT1B; LNX2; LIMD1; ZDHHC1

Interacting Protein

ADAM12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM12.
SH3D19

ADAM12 Related Articles

Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
Kerna, I; Kisand, K; et al. The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. JOINT BONE SPINE 81:51-56(2014).