ADAM12 Protein, ADAM metallopeptidase domain 12


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Official Full Name ADAM metallopeptidase domain 12
Background This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Synonyms ADAM12; ADAM metallopeptidase domain 12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Rabbit
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse ADAM12-2594M Recombinant Mouse ADAM12 Protein (206-706 aa), His-Myc-tagged E.coli His/Myc
    Mouse ADAM12-2799M Recombinant Mouse ADAM12 Protein (206-706 aa), His-Myc-tagged Insect Cell His/Myc
    Human ADAM12-365H Recombinant Human ADAM12 protein, His-tagged HEK293 His
    Human ADAM12-216H Recombinant Human ADAM12, C13&N15-labeled HEK293 N/A
    Human ADAM12-2179H Recombinant Human ADAM12, His tagged Human Cell His
    Human ADAM12-233H Recombinant Human ADAM12, His-tagged CHO His
    Human ADAM12-2592HCL Recombinant Human ADAM12 cell lysate Human Cell N/A
    Human ADAM12-264H Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform, His-tagged E.coli His
    Human ADAM12-274H Recombinant Human ADAM12 Protein, GST-tagged Wheat Germ GST
    Human CABT-676MH Mouse Anti-Human ADAM Metallopeptidase Domain 12 Monoclonal Antibody Mouse N/A
    Human CPBT-676RH Rabbit Anti-Human ADAM Metallopeptidase Domain 12 Polyclonal Antibody Rabbit N/A
    Mouse ADAM12-1277M Recombinant Mouse ADAM12 Protein Mammalian Cell His
    Chicken ADAM12-3898C Recombinant Chicken ADAM12 Mammalian Cell His

    ADAM12 involved in several pathways and played different roles in them. We selected most pathways ADAM12 participated on our site, such as Notch signaling pathway, Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway LFNG; NUMBL; NOTCH4; EP300; ADAM12; DTX3L; PSEN2; CNTN6; LNX1; DVL1B
    Signal Transduction SOX32; CBY1; NET1; CRHR2; SOX6; SAGB; AMOTL2; GREM2; SST1.1; GPR65
    Signaling by EGFR LRIG1; ADAM12; PTPRK; SPRY1; PAG1
    Syndecan-4-mediated signaling events MDK; ADAM12; GIPC1

    ADAM12 has several biochemical functions, for example, SH3 domain binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM12 itself. We selected most functions ADAM12 had, and list some proteins which have the same functions with ADAM12. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding SH3BP2; EVLB; ITM2B; EPS15; DOCK1; FAM125A; INPPL1B; CYBA; MAPK15; MYPN
    metalloendopeptidase activity UQCRC2B; C6AST4; MMP14A; MMP25; MBTPS2; TLL1; PMPCB; ECE2; MMP28; ADAM8
    metallopeptidase activity ERMP1; AMZ2; NPSN; BMP1; CLCA1; BRCC3; CLCA5; ADAM9; DNPEP; ECEL1
    protein binding NDUFB11; FXYD6; C9orf142; RAB3B; SPG7; PTCRA; EPB42; IRS1; MPDU1; CFL1
    zinc ion binding VPS41; PGLYRP5; PYGO2; KLF4; TRIM64C; RNF113A; ESR2; BRF1A; THRAA; SKI

    ADAM12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM12.


    Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
    Kerna, I; Kisand, K; et al. The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. JOINT BONE SPINE 81:51-56(2014).

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