ADAM12
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Official Full Name
ADAM metallopeptidase domain 12
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Overview
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014] -
Synonyms
ADAM12; ADAM metallopeptidase domain 12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mouse
- Rabbit
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ADAM12 Related Articles
- ADAM12 Related Research Area
ADAM12 involved in several pathways and played different roles in them. We selected most pathways ADAM12 participated on our site, such as Notch signaling pathway, Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DTX3L;JAG1B;APH1C;NUMB;APH1B;PSEN1;CTBP2A;PTCRA;DLB |
| Signal Transduction | PCSK6;PRDM4;ARHGAP19;CDC42EP5;EMR3;MDKA;DACT1;KIF14;FABP11A |
| Signaling by EGFR | PTPRK;ADAM12;LRIG1;PAG1;SPRY1 |
| Syndecan-4-mediated signaling events | GIPC1;ADAM12;MDK |
ADAM12 has several biochemical functions, for example, SH3 domain binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM12 itself. We selected most functions ADAM12 had, and list some proteins which have the same functions with ADAM12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | ABL1;MICAL1;CTTNBP2;RAD9;SGIP1;ARHGAP27;GPX1;CD2AP;AFAP1L2 |
| metalloendopeptidase activity | ADAM15;PHEX;C6AST1;ADAMTS10;KEL;MMP14A;ADAM18;ADAMTS16;MMP2 |
| metallopeptidase activity | NAALADL1;CNDP2;ADAMTS7;ADAM8;MMP30;DNPEP;ERAP2;CPD;BMP1 |
| protein binding | SMG5;BIRC3;LEF1;FBLIM1;GHR;C15orf57;HIST1H4C;KIF5C;FZD6 |
| zinc ion binding | ZMIZ1A;BRAP;ESRRG;Car9;PDLIM4;MARCH10;BIRC7;SIAH1;DTX3 |
ADAM12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM12.
SH3D19
- Q&As
- Reviews
Q&As (6)
Ask a questionCurrently, ADAM12 is also involved in the study of lung cancer and liver cancer.
ADAM12 upregulates the expression of Vimentin.
ADAM12 interacts with insulin-like growth factor binding protein(IGFBP)-3.
We offer myoferlin and Vimentin proteins in addition to ADAM12 proteins.
ADAM12 protein can hydrolyze Delta-like 1、Ephrin-A1, etc.
The two conformations of ADAM are the membrane-penetrating full-length type (ADAM12-L) and the secretory type (ADAM12-S), respectively.
Customer Reviews (2)
Write a reviewThe technical staff evaluated my experimental process and results and made many constructive comments
Protein products are put into experiments with good effect and reliable experimental results
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