adamts8
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  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; METH2; ADAM-TS8; A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8;
Cat.#:ADAMTS8-29HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS8 Protein, MYC/DDK-tagged
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Cat.#:ADAMTS8-3009HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS8, His-tagged
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Cat.#:ADAMTS8-309HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAMTS8 Protein, GST-tagged
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Cat.#:Adamts8-3016MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Adamts8, His-tagged
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Cat.#:ADAMTS8-9027HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADAMTS8 293 Cell Lysate
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Involved Pathway

ADAMTS8 involved in several pathways and played different roles in them. We selected most pathways ADAMTS8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of the extracellular matrix
ADAM15; CTSLL; BSG; MMP11; ADAMTS1; MMP17; CTSL1; CMA1; BMP1B; MMP24
Extracellular matrix organization
MMP11; FMOD; MUSK; CTSLL; COL5A1; DDR2; CD151; COL4A6; COL8A1; ADAM8A
Metabolism of proteins
PMPCB; ADAMTSL5; WDR85; ST6GALNAC1.2; MBOAT4; EEF1B2; B3GALTL; MUC21; SEC61B; IGFBP6A
O-glycosylation of TSR domain-containing proteins
B3GALTL; ADAMTSL3; SPON1; ADAMTS10; ADAMTS3; ADAMTSL5; SSPO; ADAMTS5; ADAMTS18; ADAMTS15
O-linked glycosylation
B3GNT6; THSD1; ADAMTS10; ADAMTSL1; ST6GALNAC2; B3GALTL; SPON1A; MUC1; MUC4; ADAMTS18
Post-translational protein modification
MCFD2; WDR85; SCMH1; TRAPPC9; DPH1; MGAT4B; ST8SIA3; NSMCE2; NEU4; TRAPPC4

Protein Function

ADAMTS8 has several biochemical functions, for example, heparin binding, integrin binding, low-affinity phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS8 itself. We selected most functions ADAMTS8 had, and list some proteins which have the same functions with ADAMTS8. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein SLIT1A; HRG; MMP7; SFRP1; PLA2G5; ANG; PDCD5; FGF10; LIPH; CECR1
Function integrin binding
Related Protein TGFBI; ACTN1; ICAM1; ADAM23; WISP3; FN1; WISP1A; ADAM15; S1PR2; AMICA1
Function low-affinity phosphate transmembrane transporter activity
Related Protein ADAMTS8
Function metalloendopeptidase activity
Related Protein PAPPAA; Adamts19; MMP14B; ADAM8; ADAM9; ADAM32; HE1B; MBTPS2; FAP; ADAM23
Function metallopeptidase activity
Related Protein ADAM8A; ADAMTS16; BMP1B; COPS5; MMP14A; MMP13A; CPD; ADAMTS1; AGBL4; PAPPAA
Function zinc ion binding
Related Protein ASH1L; AICDA; SRSF7; ZNFL1; ZCCHC10; TGFB1I1; ZYX; RNF115; PRKCBP1L; CREBBP