Recombinant Full Length Human ADAMTS8 Protein, C-Flag-tagged

• Cat.No.: ADAMTS8-605HFL
• Product Overview: Recombinant Full Length Human ADAMTS8 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 96.3 kDa
• AA Sequence: MLPAPAAPRWPPLLLLLLLLPLARG APARPAAGGQASELVVPTRLPGSAG ELALHLSAFGKGFVLRLAPD DSFLAPDFKIERLGGSGRATGGERG LRGCFFSGTVNGEPESLAAVSLCRG LSGSFLLDGEEFTIQPQGAG GSLAQPHRLQRWGPAGARPLPRGPE WEVETGEGQRQERGDHQEDSEEESQ EEEAEGASEPPPPLGATSRT KRFVSEARFVETLLVADASMAAFYG ADLQNHILTLMSVAARIYKHPSIKN SINLMVVKVLIVEDEKWGPE VSDNGGLTLRNFCNWQRRFNQPSDR HPEHYDTAILLTRQNFCGQEGLCDT LGVADIGTICDPNKSCSVIE DEGLQAAHTLAHELGHVLSMPHDDS KPCTRLFGPMGKHHVMAPLFVHLNQ TLPWSPCSAMYLTELLDGGH GDCLLDAPAAALPLPTGLPGRMALY QLDQQCRQIFGPDFRHCPNTSAQDV CAQLWCHTDGAEPLCHTKNG SLPWADGTPCGPGHLCSEGSCLPEE EVERPKPVVDGGWAPWGPWGECSRT CGGGVQFSHRECKDPEPQNG GRYCLGRRAKYQSCHTEECPPDGKS FREQQCEKYNAYNYTDMDGNLLQWV PKYAGVSPRDRCKLFCRARG RSEFKVFEAKVIDGTLCGPETLAIC VRGQCVKAGCDHVVDSPRKLDKCGV CGGKGNSCRKVSGSLTPTNY GYNDIVTIPAGATNIDVKQRSHPGV QNDGNYLALKTADGQYLLNGNLAIS AIEQDILVKGTILKYSGSIA TLERLQSFRPLPEPLTVQLLTVPGE VFPPKVKYTFFVPNDVDFSMQSSKE RATTNIIQPLLHAQWVLGDW
  SECSSTCGAGWQRRTVECRDPSGQA SATCNKALKPEDAKPCESQLCPLTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein

Gene Information

• Gene Name: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS8
• Synonyms: METH2; ADAM-TS8
• Gene ID: 11095
• mRNA Refseq: NM_007037.6
• Protein Refseq: NP_008968.4
• MIM: 605175
• UniProt ID: Q9UP79