adh5
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  • Official Full Name
  • alcohol dehydrogenase 5 (class III), chi polypeptide
  • Background
  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
  • Synonyms
  • ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide; FDH, formaldehyde dehydrogenase; alcohol dehydrogenase class-3; ADH 3; ADHX; Alcohol dehydrogenase (class III) chi polypeptide; alcohol dehydrogenase 5 (class III) chi polypeptide; Alcohol dehydrogenase class 3; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class III; class III alcohol dehydrogenase 5 chi subunit; FDH; formaldehyde dehydrogenase; Glutathione dependent formaldehyde dehydrogenase; hydroxymethyllutathione dehydrogenase; OTTHUMP00000219913; alcohol dehydrogenase class-III; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; alcohol dehydroge; ADH-3; FALDH; GSNOR; GSH-FDH
Cat.#:ADH5-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADH5 Protein, His-tagged
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Cat.#:ADH5-1317HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ADH5 Protein (2-374 aa), His-tagged
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Cat.#:ADH5-1370HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADH5 Protein, MYC/DDK-tagged
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Cat.#:ADH5-27095THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADH5, His-tagged
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Cat.#:ADH5-13564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADH5, His-tagged
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Cat.#:ADH5-349HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADH5 Protein, GST-tagged
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Cat.#:ADH5-1355MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADH5 Protein
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Cat.#:Adh5-3257RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Adh5, His-tagged
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Cat.#:ADH5-524RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADH5 Protein
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Cat.#:ADH5-2824CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADH5
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Cat.#:ADH5-9355ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADH5
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Cat.#:ADH5-30HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADH5 cell lysate
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Involved Pathway

ADH5 involved in several pathways and played different roles in them. We selected most pathways ADH5 participated on our site, such as Biological oxidations, Biosynthesis of antibiotics, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
AHCY; CYP2Y3; CYP2C18; FDX1L; CYP2D6; PAOX; FDXR; ACY3; CYP21A2; ACY3.1
Biosynthesis of antibiotics
DAO1; AK7; DLST; ANI_1_2390104; DLD; ACAA2; AK8; CS; GLYCTK; AGXT
Carbon metabolism
PRPS1L1; MDH1AA; GPT; MCEE; MUT; PGP; FBP2; G6PD; PCCB; ALDOCA
Chemical carcinogenesis
MGST2; UGT1A2; CYP1A1; PTGS2; GSTP2; EPHX1; ADH2-2; CYP3A43; CYP2C55; SULT2A1
Degradation of aromatic compounds
AKR1A1A; RGN; AKR1A1; AKR1A1B; ADH5
Drug metabolism - cytochrome P450
CYP2C9; CYP2B6; ADH1A; CYP2C19; CYP3A5; GSTK1; CYP2E1; CYP2C8; ADH2-1; ADH7
Ethanol oxidation
ADH4; ADH1A; ADH1C; ADH8A; ADH1B; ADH6; ADH7; ADH8B; ADH5
Fatty acid degradation
GCDH; ADH2-2; ACAA1A; ACOX1; ALDH9A1; ACSBG2; ALDH2.2; ALDH7A1; CPT1B; ACADSB

Protein Function

ADH5 has several biochemical functions, for example, S-(hydroxymethyl)glutathione dehydrogenase activity, alcohol dehydrogenase (NAD) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH5 itself. We selected most functions ADH5 had, and list some proteins which have the same functions with ADH5. You can find most of the proteins on our site.
Function
Related Protein
Function S-(hydroxymethyl)glutathione dehydrogenase activity
Related Protein ADH5
Function alcohol dehydrogenase (NAD) activity
Related Protein ADH8B; ADH1C; ADH5; ADH7; ADH1A; ADH4; DHRS9; ADH8A; ADH1; ADH6
Function electron carrier activity
Related Protein GLDC; ALDH4A1; ACOX3; NDUFS3; ACADL; NCF1; UGDH; ACOXL; MAOB; GCDH
Function fatty acid binding
Related Protein LBFABP; FABP4; APOC1; NDUFAB1; FABP5; FABP1B.1; GPR120; Alb; FABP7A; ADH5
Function formaldehyde dehydrogenase activity
Related Protein ADH5; ADH8B
Function protein homodimerization activity
Related Protein PRPS2; PRMT8; TOP2A; HHEX; KCNK9; DMRT3; TGFB1; IKBKG; UXS1; SLC9A7
Function zinc ion binding
Related Protein NEIL1; LIMD2; MT1X; MMP19; RNF114; GFI1AA; MMP24; CBLC; RAG2; CA4B

Interacting Protein

ADH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH5.
VTN; ESRRA; ARNT; CSNK2B; PRDX1; CHD3; PQLC1; HDAC1