| Description : |
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
39.5 kDa |
| AA Sequence : |
MANEVIKCKAAVAWEAGKPLSIEEI EVAPPKAHEVRIKIIATAVCHTDAY TLSGADPEGCFPVILGHEGA GIVESVGEGVTKLKAGDTVIPLYIP QCGECKFCLNPKTNLCQKIRVTQGK GLMPDGTSRFTCKGKTILHY MGTSTFSEYTVVADISVAKIDPLAP LDKVCLLGCGISTGYGAAVNTAKLE PGSVCAVFGLGGVGLAVIMG CKVAGASRIIGVDINKDKFARAKEF GATECINPQDFSKPIQEVLIEMTDG GVDYSFECIGNVKVMRAALE ACHKGWGVSVVVGVAASGEEIATRP FQLVTGRTWKGTAFGGWKSVESVPK LVSEYMSKKIKVDEFVTHNL SFDEINKAFELMHSGKSIRTVVKI TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome |
| Protein Pathways : |
Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Methane metabolism, Retinol metabolism, Tyrosine metabolism |
