adk
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  • Official Full Name
  • adenosine kinase
  • Background
  • This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ADK; adenosine kinase; adenosine 5 phosphotransferase; AK; 5033405D03Rik; AI255373; AI987814; MGC6593; 2310026J05Rik; ADK_HUMAN; OTTHUMP00000019864; OTTHUMP00000019865; adenosine 5-phosphotransferase
Cat.#:ADK-1290ETag:His
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant Escherichia coli ADK Protein (1-214 aa), His-tagged
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Cat.#:ADK-1366HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADK Protein, MYC/DDK-tagged
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Cat.#:ADK-493HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADK Protein, His-tagged
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Cat.#:Adk-245HTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Adk Protein, His-tagged, Bioactivity Validated
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Cat.#:Adk-494MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Adk Protein, His/GST-tagged
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Cat.#:ADK-1108STag:His-SUMO/MYC
Source (Host):E. coliSpecies:S. flexneri
Product nameRecombinant S. flexneri ADK Protein, His-SUMO/MYC-tagged
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Cat.#:ADK-26098THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADK, His-tagged
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Cat.#:ADK-1343HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADK, His & GST tagged
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Cat.#:ADK-2481HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Adenosine Kinase, His-tagged
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Cat.#:ADK-359HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADK Protein, GST-tagged
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Cat.#:ADK-1364MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADK Protein
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Cat.#:Adk-3158MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Adk, His-tagged
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Cat.#:ADK-529RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADK Protein
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Cat.#:ADK-250RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADK Protein, His-tagged
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Cat.#:ADK-1640CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADK
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Cat.#:ADK-0127BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis ADK protein, His-tagged
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Cat.#:ADK-2817STag:His
Source (Host):E. coli or YeastSpecies:Staphylococcus
Product nameRecombinant Staphylococcus epidermidis ATCC 12228 ADK protein, His-tagged
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Cat.#:ADK-904STag:His
Source (Host):E. coli or YeastSpecies:Streptomyces coelicolor A3(2)
Product nameRecombinant Streptomyces coelicolor A3(2) ADK protein, His-tagged
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Cat.#:ADK-505HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADK cell lysate
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Cat.#:Kit-0878Tag:
Source (Host):Species:
Product nameADK Phosphorylation Assay Kit
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Cat.#:Kit-0880Tag:
Source (Host):Species:
Product nameADK Assay Kit
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Involved Pathway

ADK involved in several pathways and played different roles in them. We selected most pathways ADK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
ATP5B; ATP5A1; DNMT4; ACSL4A; NAT1; PGAM1; BCKDHB; FBP2; ATP6V1G2; ATP6V0CB
Metabolism
LOC100686744; NDOR1; SLC25A21; CHKA; DHCR7; FABP9; AKR1C6; APOA4B.2; GGTLC1; SLC6A12
Metabolism of nucleotides
ADSL; AK8; ADK; ITPA; TM9SF1; DPYDA.1; DPYD; UPP2; NUDT18; AK7A
Purine metabolism
NME2A; PDE2A; PDE6D; PDE6G; ENPP1; CECR1; ATIC; ENTPD8; NT5C1AA; POLR3C
Purine salvage
DCK; ADK; TM9SF1; ADA; DGUOK; PNP5B; ADAL
adenine and adenosine salvage II
ADK
adenine and adenosine salvage VI
ADK
superpathway of purine nucleotide salvage
ADK

Protein Function

ADK has several biochemical functions, for example, ATP binding, adenosine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADK itself. We selected most functions ADK had, and list some proteins which have the same functions with ADK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP13A3; SMARCA2; CHD7; STK19; FLT3; ASS1; AACS; ABCF3; MAPK4; ICK
Function adenosine kinase activity
Related Protein ADKA; ADKB; ADK
Function metal ion binding
Related Protein CYP4V8; VAV3; ZNF461; GNAT3; ROCK2; PPP4CA; ZKSCAN4; PFAS; AOX4; MGRN1B
Function poly(A) RNA binding
Related Protein BYSL; PURB; RPS16; MRPL4; TBRG4; HIST1H4L; SNRPG; PUS7; TNPO1; BCCIP

Interacting Protein

ADK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADK here. Most of them are supplied by our site. Hope this information will be useful for your research of ADK.
btuB; FICD; SRD5A3; 15-deoxy-delta(12,14; bosutinib; imatinib; dasatinib; sch51344

ADK Related Articles

Pukazhvanthen, P; Anbarasu, D; et al. Assessing humoral immune response of 4 recombinant antigens for serodiagnosis of tuberculosis. TUBERCULOSIS 94:622-633(2014).
Cui, XA; Singh, B; et al. Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388:46-50(2009).