aes
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  • Official Full Name
  • amino-terminal enhancer of split
  • Background
  • The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • AES; amino-terminal enhancer of split; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; gp130-associated protein GAM;
Cat.#:AES-544HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AES Protein, MYC/DDK-tagged
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Cat.#:AES-27927THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AES, His-tagged
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Cat.#:AES-28533THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AES, His-tagged
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Cat.#:AES-3479HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AES, His-tagged
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Cat.#:AES-397HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AES Protein, GST-tagged
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Cat.#:AES-398HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AES Protein, GST-tagged
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Cat.#:AES-1396MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AES Protein
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Cat.#:Aes-3423MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Aes, His-tagged
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Cat.#:AES-552RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AES Protein
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Cat.#:AES-282CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AES Protein, His-tagged
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Cat.#:AES-10734ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AES
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Cat.#:AES-8991HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AES 293 Cell Lysate
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Involved Pathway

AES involved in several pathways and played different roles in them. We selected most pathways AES participated on our site, such as Androgen receptor signaling pathway, Degradation of beta-catenin by the destruction complex, Presenilin action in Notch and Wnt signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Androgen receptor signaling pathway
CTNNB2; CCDC102A; PATZ1; HMGB2A; SMARCE1; RHOB; HTATIP; JUN; RANBP9; MYST2
Degradation of beta-catenin by the destruction complex
TLE3; TLE3B; TLE1; TLE4; CTBP1; FAM123B; TLE2; AES; CTBP2
Presenilin action in Notch and Wnt signaling
KREMEN2; WIF1; TLE1; AES
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
TLE1; BCL9; KCNIP4; MYOG; TCF4; AES; KRT1; HBP1; TNIK; TLE4
Repression of WNT target genes
AES; TLE2; TLE3; TLE3B; TLE4
Signal Transduction
TRH; ARHGEF3; ZFPM2B; TLE3; NTS; GPR55A; RGS1; SRY; GAL; METAP2A
Signaling by Wnt
SOX6; USP34; CBY1; SOX9B; SOX4A; TNKS2; RSPO4; C; ROR1; AES

Protein Function

AES has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AES itself. We selected most functions AES had, and list some proteins which have the same functions with AES. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein KRT6A; YEATS4; HCST; RAB1B; BUD31; RMI1; WASF1; TSPAN15; MTMR14; ATXN1
Function transcription corepressor activity
Related Protein WNT4; CTCF; HDAC3; TRIB3; RBFOX2; IRF2BP2; MYBBP1A; BATF3; SSX1; ASXL1

Interacting Protein

AES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AES here. Most of them are supplied by our site. Hope this information will be useful for your research of AES.
PTRH2; KRT13; FSD2; VPS37C; ARHGAP32; 386682

AES Related Articles

Zhou, XL; Wang, JM; et al. Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular lymphoma. HEMATOLOGY 20:129-136(2015).
Krishnan, A; Stobaugh, DJ; et al. Assessing the likelihood of new-onset inflammatory bowel disease following tumor necrosis factor-alpha inhibitor therapy for rheumatoid arthritis and juvenile rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL 35:661-668(2015).