akr1a1
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  • Official Full Name
  • aldo-keto reductase family 1, member A1 (aldehyde reductase)
  • Background
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
  • Synonyms
  • AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); alcohol dehydrogenase [NADP(+)]; ALR; DD3; dihydrodiol dehydrogenase 3; aldehyde reductase; alcohol dehydrogenase; aldo-keto reductase family 1 member A1; ARM; ALDR1; MGC1380; MGC12529
Cat.#:AKR1A1-129HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1A1 protein, His-tagged
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Cat.#:AKR1A1-2495HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1A1, His tagged
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Cat.#:AKR1A1-408HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1A1 Protein, GST-tagged
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Cat.#:AKR1A1-485HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1A1
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Cat.#:AKR1A1-9530HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1A1, GST-tagged
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Cat.#:Akr1a1-3259RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Akr1a1, His-tagged
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Cat.#:AKR1A1-595RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKR1A1 Protein
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Cat.#:AKR1A1-291RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKR1A1 Protein, His-tagged
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Cat.#:AKR1A1-1677CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKR1A1
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Cat.#:AKR1A1-8932HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKR1A1 293 Cell Lysate
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Involved Pathway

AKR1A1 involved in several pathways and played different roles in them. We selected most pathways AKR1A1 participated on our site, such as Benzo(a)pyrene metabolism, Biological oxidations, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Benzo(a)pyrene metabolism
CYP3A4; AKR1C4; AKR1C2; FAM84B; CYP1A1; AKR1A1; CYP1B1
Biological oxidations
CYP4B1; ACY3.1; CYP2K17; CYP2A13; SULT1ST5; GSTO2; CYP2J2; ADH8A; CYP2C18; SULT2ST1
Biosynthesis of antibiotics
DLAT; EHHADH; pykF; GPR19; ACAA2; LDHAL6B; CS; UAP1L1; DAO1; GLYCTK
Catabolism of glucuronate to xylulose-5-phosphate
AKR1A1; OXSR1
Degradation of aromatic compounds
ADH5; AKR1A1; AKR1A1A; RGN; AKR1A1B
Glutathione conjugation
AKR1A1; GGT6; GGTLC1; GSTO2; GSTK1
Glycerolipid metabolism
DGAT1; GK2; MOGAT1; LIPC; DGKD; LPIN2; DGKQ; DGKE; AKR1A1B; PPAP2D
Glycolysis / Gluconeogenesis
ALDH9A1; HK3; LDHA; ALDH7A1; PKMB; G6PC3; ALDH1B1; GPI; ADPGK; ALDOCA

Protein Function

AKR1A1 has several biochemical functions, for example, L-glucuronate reductase activity, alditol:NADP+ 1-oxidoreductase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1A1 itself. We selected most functions AKR1A1 had, and list some proteins which have the same functions with AKR1A1. You can find most of the proteins on our site.
Function
Related Protein
Function L-glucuronate reductase activity
Related Protein AKR1A1
Function alditol:NADP+ 1-oxidoreductase activity
Related Protein Akr1b3; AKR1B1; AKR1C3; AKR1C2; AKR7A5; AKR1C21; PRKRA; AKR7A2; ADH4; AKR1B7
Function electron carrier activity
Related Protein DHRS3; TXNRD1; P4HA2; QDPR; ACAD11; ALDH2; CYP1A2; NDUFA12; XDH; NQO2
Function protein binding
Related Protein SFRP1; ADRA2C; WIPI2; HYI; APOA1; S1PR3; R3HDM2; HOMEZ; SRGAP1; NR2C2

Interacting Protein

AKR1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1A1.
TERF2IP; TERF1; q8czt6_yerpe; EXOSC4