• Official Full Name
  • aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
  • Background
  • The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde.
  • Synonyms
  • AKR7A2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); aflatoxin B1 aldehyde reductase member 2; AFAR; AFB1-AR 1; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 alde
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR7A2, His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR7A2 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKR7A2 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKR7A2 Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR7A2, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human AKR7A2 cell lysate

Involved Pathway

AKR7A2 involved in several pathways and played different roles in them. We selected most pathways AKR7A2 participated on our site, such as Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR7A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of xenobiotics by cytochrome P

Protein Function

AKR7A2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, electron carrier activity, phenanthrene-9,10-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR7A2 itself. We selected most functions AKR7A2 had, and list some proteins which have the same functions with AKR7A2. You can find most of the proteins on our site.
Related Protein
Function alditol:NADP+ 1-oxidoreductase activity
Related Protein AKR1C21; AKR1B7; PRKRA; AKR1B1; AKR1C3; AKR7A5; ADH4; AKR1B8; AKR1C2; Akr1b3
Function electron carrier activity
Related Protein NCF1; FDX1B; TXNRD1; ACOX2; GCDH; P4HA2; ME1; COX7A1; GRXCR1; CIAPIN1
Function phenanthrene-9,10-epoxide hydrolase activity
Related Protein AKR7A5; AKR7A2; PRKRA

Interacting Protein

AKR7A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR7A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR7A2.
HLA-B; AKR7A3; Tpx2; Trp53bp1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; KATNA1; RALA; PCNA; CCNB1; VCAM1; CDK2; MSH6; C21orf59; Mark2; SMC1A; Prkaa1; Cep131