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Recombinant Human AKR7A2 Protein, GST-tagged

Cat.No. : AKR7A2-418H
Product Overview : Human AKR7A2 full-length ORF ( AAH04111.3, 1 a.a. - 330 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 61.82 kDa
AA Sequence : MSRPPPPRVASVLGTMEMGRRMDAP ASAAAVRAFLERGHTELDTAFMYSD GQSETILGGLGLGLGGGDCRVKIAT KANPWDGKSLKPDSVRSQLETSLKR LQCPQVDLFYLHAPDHGTPVEETLH ACQRLHQEGKFVELGLSNYASWEVA EICTLCKSNGWILPTVYQGMYNATT RQVETELFPCLRHFGLRFYAYNPLA GGLLTGKYKYEDKDGKQPVGRFFGN SWAETYRNRFWKEHHFEAIALVEKA LQAAYGASAPSVTSAALRWMYHHSQ LQGAHGDAVILGMSSLEQLEQNLAA TEEGPLEPAVVDAFNQAWHLVAHEC PNYFR
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) [ Homo sapiens ]
Official Symbol : AKR7A2
Synonyms : AKR7A2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); aflatoxin B1 aldehyde reductase member 2; AFAR; AFB1-AR 1; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 aldehyde reductase; AKR7; AFAR1; AFB1-AR1;
Gene ID : 8574
mRNA Refseq : NM_003689
Protein Refseq : NP_003680
MIM : 603418
UniProt ID : O43488

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Can dysregulation of AKR7A2 be associated with diseases? 03/13/2023

Yes, dysregulation of AKR7A2 has been implicated in several diseases. Reduced AKR7A2 expression or activity has been linked to increased susceptibility to oxidative stress-induced tissue damage, cancer development, and age-related diseases such as Alzheimer's disease and Parkinson's disease. On the other hand, overexpression or altered activity of AKR7A2 may contribute to drug resistance in some cancer cells.

Can AKR7A2 be used as a biomarker? 11/02/2022

AKR7A2 has shown potential as a biomarker for certain diseases and drug response. For example, its expression levels have been correlated with drug resistance in some cancer cells, making it a potential biomarker for predicting treatment response. Additionally, altered AKR7A2 expression or activity has been observed in neurodegenerative diseases, suggesting its potential as a biomarker for disease prognosis.

Are there any genetic variations or mutations in the AKR7A2 gene? 10/15/2022

Yes, genetic variations and mutations have been reported in the AKR7A2 gene. Some of these variations are associated with altered enzyme activity or expression levels of AKR7A2. Certain genetic variants may also confer susceptibility to certain diseases or impact drug metabolism.

Is AKR7A2 protein involved in drug metabolism? 06/07/2022

Yes, AKR7A2 plays a role in drug metabolism. It is involved in the detoxification and elimination of certain drugs and their metabolites from the body. This activity helps protect cells and tissues from drug-induced damage.

Where is AKR7A2 protein primarily expressed in the body? 04/07/2022

AKR7A2 is widely expressed in various tissues throughout the body, including the liver, kidney, lung, brain, and gastrointestinal tract. It is also present in certain cancer cells.

Are there any ongoing research studies on AKR7A2 protein? 03/12/2022

Yes, there are ongoing research studies on AKR7A2 protein. Scientists are continuing to investigate its role in drug metabolism, detoxification pathways, and its potential as a therapeutic target for various diseases. Additionally, researchers are exploring the use of AKR7A2 as a biomarker for disease prognosis and drug response.

Can AKR7A2 be a target for drug development? 11/12/2021

Yes, AKR7A2 has the potential to be a target for drug development. Its involvement in drug metabolism and detoxification pathways makes it an attractive target for enhancing the efficacy of certain drugs or developing novel therapeutics. However, further research is needed to fully understand its role and to identify specific inhibitors or activators that can be used as pharmaceutical agents.

Are there any inhibitors or activators of AKR7A2? 09/17/2021

Several compounds have been identified as inhibitors of AKR7A2, such as flufenamic acid and naproxen. On the other hand, there is limited information available about activators of AKR7A2. Further research is needed to identify specific modulators of AKR7A2 activity.

How is AKR7A2 involved in drug metabolism? 02/10/2021

AKR7A2 plays a role in drug metabolism by catalyzing the conversion of reactive aldehydes generated during drug metabolism into inactive and easily excretable forms. This detoxification process helps eliminate potentially harmful metabolites and promotes drug clearance from the body. Therefore, AKR7A2 can affect the efficacy and toxicity of certain drugs.

Are there any known substrates of AKR7A2? 12/22/2020

AKR7A2 acts on a wide range of substrates, including aldehydes derived from lipid peroxidation, such as 4-HNE, as well as endogenous and exogenous carbonyl compounds, pharmaceutical drugs, and toxins. It catalyzes the reduction of these substrates to their corresponding alcohols.

Are there any diseases associated with AKR7A2 protein? 11/14/2020

Mutations in the AKR7A2 gene have been linked to a rare genetic disorder called autosomal recessive adult-onset motor neuron disease (AR-AMN). This disease is characterized by a slowly progressive movement disorder and distal limb muscle weakness. The exact role of AKR7A2 in this disease is not fully understood.

Are there any genetic variations or polymorphisms in the AKR7A2 gene? 11/26/2019

Yes, genetic variations and polymorphisms have been identified in the AKR7A2 gene. These variations can result in different forms of the AKR7A2 protein with altered enzymatic activity or stability. Some of these polymorphisms have been associated with an increased risk for certain diseases or altered drug metabolism.

Are there any known inhibitors or activators of AKR7A2? 07/03/2019

Several compounds have been identified as inhibitors or activators of AKR7A2. For example, some nonsteroidal anti-inflammatory drugs (NSAIDs) and their metabolites have been shown to inhibit AKR7A2 activity. On the other hand, certain dietary compounds such as curcumin and resveratrol have been found to activate AKR7A2 expression and increase its enzymatic activity.

What are the potential therapeutic implications of AKR7A2 protein? 05/30/2019

Due to its detoxification capabilities, AKR7A2 has been explored as a potential target for therapeutic intervention in conditions associated with aldehyde toxicity, such as neurodegenerative diseases and oxidative stress-related disorders. Developing drugs that modulate or enhance AKR7A2 activity could be a potential avenue for future treatments.

How is the activity of AKR7A2 regulated? 01/22/2019

The activity of AKR7A2 can be regulated at multiple levels. It is known to undergo post-translational modifications, such as phosphorylation and acetylation, which can affect its enzymatic activity and stability. Additionally, the expression of AKR7A2 can be influenced by various transcription factors and signaling pathways, such as the Nrf2/ARE pathway, which is involved in response to oxidative stress.

Does AKR7A2 protein have any physiological functions? 10/17/2018

Yes, AKR7A2 has several physiological functions. It is involved in the detoxification of reactive aldehydes and other toxic carbonyl compounds. Additionally, AKR7A2 participates in oxidative stress response, lipid metabolism, and protection against DNA damage.

Where is AKR7A2 protein found? 10/10/2018

AKR7A2 is predominantly expressed in the liver, but it is also present in various tissues including the brain, kidney, lung, and testis. It is localized in the cytoplasm of cells.

What are the functions of AKR7A2 protein? 10/03/2018

AKR7A2 plays a critical role in the detoxification of reactive aldehydes and carbonyl compounds, thus protecting cells from their potentially toxic effects. It is involved in the metabolism of drugs, toxins, and endogenous aldehydes like 4-hydroxynonenal (4-HNE), which is a product of lipid peroxidation.

Can AKR7A2 influence drug resistance? 06/29/2018

Yes, AKR7A2 has been implicated in drug resistance in cancer cells. Increased expression or altered activity of AKR7A2 can lead to enhanced detoxification of anticancer drugs, reducing their effectiveness against tumor cells. This drug resistance mechanism has been observed in various cancer types and underscores the importance of understanding the role of AKR7A2 in drug response.

How is AKR7A2 protein regulated? 07/23/2017

The expression and activity of AKR7A2 can be regulated by various factors. For example, the AKR7A2 gene expression can be induced by oxidative stress and certain chemicals through activation of specific transcription factors. Post-translational modifications, such as phosphorylation, can also modulate AKR7A2 activity.

How is AKR7A2 protein related to diabetic complications? 05/15/2017

AKR7A2 has been implicated in the development of diabetic complications, particularly diabetic nephropathy. It is thought to be involved in the metabolism of glucose and related byproducts, as well as the detoxification of reactive aldehydes generated in diabetic conditions.

Customer Reviews (4)

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Reviews
03/10/2023

    The AKR7A2 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

    02/16/2022

      One remarkable aspect of working with the AKR7A2 protein is the excellent technical support provided by its manufacturer.

      07/24/2019

        With its reliable performance and consistent results, the AKR7A2 protein provides researchers with the confidence and accuracy required for successful experimentation.

        12/29/2018

          Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

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