aldh1a1
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  • Official Full Name
  • aldehyde dehydrogenase 1 family, member A1
  • Background
  • The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
  • Synonyms
  • ALDH1A1; aldehyde dehydrogenase 1 family, member A1; ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e; retinal dehydrogenase 1; ALHDII; RALDH 1; ALDH class 1; acetaldehyde dehydrogenase 1; epididymis luminal protein 9; epididymis luminal protein 12; retinaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; epididymis secretory sperm binding protein Li 53e;
Cat.#:ALDH1A1-1845MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse ALDH1A1 Protein (2-501 aa), His-tagged
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Cat.#:ALDH1A1-27036THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1A1, His-tagged
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Cat.#:ALDH1A1-1100HTag:Met|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1A1 protein, His-tagged
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Cat.#:ALDH1A1-27035THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1A1 protein
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Cat.#:ALDH1A1-437HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH1A1 Protein, GST-tagged
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Cat.#:ALDH1A1-484HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldehyde Dehydrogenase 1 Family, Member A1
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Cat.#:ALDH1A1-883HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1A1, His tagged
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Cat.#:ALDH1A1-9550HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1A1, GST-tagged
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Cat.#:Aldh1a1-1356MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Aldh1a1 protein, His & T7-tagged
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Cat.#:ALDH1A1-1518MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH1A1 Protein
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Cat.#:ALDH1A1-614RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDH1A1 Protein
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Cat.#:ALDH1A1-6146CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALDH1A1
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Cat.#:ALDH1A1-8922HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDH1A1 293 Cell Lysate
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Involved Pathway

ALDH1A1 involved in several pathways and played different roles in them. We selected most pathways ALDH1A1 participated on our site, such as Retinol metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Retinol metabolism
PNPLA4; DHRS9; RDH8A; CYP2C37; ALDH1A1; CYP1A; CYP2C70; UGT2A3; UGT2A2; RDH10
Metabolic pathways
NT5C1A; MGAT1; GPAA1; CYP2S1; HEXB; MLYCD; ADH7; ST6GALNAC1; NT5C3B; CYP2C38

Protein Function

ALDH1A1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, GTPase activator activity, aldehyde dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1A1 itself. We selected most functions ALDH1A1 had, and list some proteins which have the same functions with ALDH1A1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-chloroallyl aldehyde dehydrogenase activity
Related Protein ALDH3B1; ALDH3B2; Aldh1a7; ALDH1A1; ALDH3A2A; ALDH9A1; ALDH3A2B; ALDH2.1; ALDH3A2; ALDH3A1
Function GTPase activator activity
Related Protein RGS5B; TBC1D16; RP2; RGS11; RASA4; TBC1D2; SOS1; ARHGAP4A; TBC1D24; RANGAP1A
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH5A1; ALDH1A1; ALDH2; ALDH9A1A.1; ALDH8A1; ALDH3A2A; ALDH9A1; ALDH1L2; Aldh1a7; ALDH7A1
Function androgen binding
Related Protein Ar; ALDH1A1; TSPO; SHBG
Function benzaldehyde dehydrogenase (NAD+) activity
Related Protein ALDH1A1; ALDH3A1; Aldh1a7
Function retinal dehydrogenase activity
Related Protein ALDH8A1; ALDH1A1; AKR1C6; ALDH1A3; Aldh1a7; AKR1C3; AKR1B10; AKR1C4; AKR1B8

Interacting Protein

ALDH1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1A1.
ALDH2; NUPR1; q5nfd5_fratt; ligA; lplJ; POT1

ALDH1A1 Related Articles

Liu, Y; Lv, DL; et al. ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis. BMC CANCER 14:-(2014).
Thomas, AG; Henry, JJ; et al. Retinoic acid regulation by CYP26 in vertebrate lens regeneration. DEVELOPMENTAL BIOLOGY 386:291-301(2014).