aldh1l1
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  • Official Full Name
  • aldehyde dehydrogenase 1 family, member L1
  • Background
  • The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
  • Synonyms
  • ALDH1L1; aldehyde dehydrogenase 1 family, member L1; formyltetrahydrofolate dehydrogenase , FTHFD; cytosolic 10-formyltetrahydrofolate dehydrogenase; 10 fTHF; cytosolic 10 formyltetrahydrofolate dehydrogenase; 10-FTHFDH; formyltetrahydrofolate dehydrogena
Cat.#:ALDH1L1-442HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH1L1 Protein, GST-tagged
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Cat.#:ALDH1L1-474HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALDH1L1 Protein, MYC/DDK-tagged
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Cat.#:ALDH1L1-491HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldehyde Dehydrogenase 1 Family, Member L1, His-tagged
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Cat.#:ALDH1L1-492HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldehyde Dehydrogenase 1 Family, Member L1, GST-tagged
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Cat.#:ALDH1L1-9554HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH1L1, His-tagged
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Cat.#:ALDH1L1-1523MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH1L1 Protein
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Cat.#:ALDH1L1-619RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDH1L1 Protein
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Cat.#:ALDH1L1-302RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ALDH1L1 Protein, His-tagged
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Cat.#:ALDH1L1-7841ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALDH1L1
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Cat.#:ALDH1L1-17HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALDH1L1 lysate
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Involved Pathway

ALDH1L1 involved in several pathways and played different roles in them. We selected most pathways ALDH1L1 participated on our site, such as Folate-Alcohol and Cancer Pathway, One Carbon Metabolism, One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Folate-Alcohol and Cancer Pathway
ALDH1L1; CYP2E1
One Carbon Metabolism
AHCY; MTHFS; FTCD; MTFMT; MTHFD2; ALDH1L1; ST20-MTHFS
One carbon pool by folate
MTHFD2L; SHMT1; AMT; SHMT2; ST20-MTHFS; ALDH1L2; ALDH1L1; MTHFS; MTHFR; GART
folate transformations I
MTHFD2; MTHFSD; ALDH1L1; ALDH1L2

Protein Function

ALDH1L1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, catalytic activity, formyltetrahydrofolate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1L1 itself. We selected most functions ALDH1L1 had, and list some proteins which have the same functions with ALDH1L1. You can find most of the proteins on our site.
Function
Related Protein
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH3A1; ALDH7A1; ALDH3B2; ALDH9A1; ALDH2; ALDH3A2A; ALDH1L1; ALDH1L2; ALDH1B1; ALDH5A1
Function catalytic activity
Related Protein RTCD1; SLC27A1A; CPS1; CKMA; ACSL3A; ACAA1A; PCYT1BB; GAD1B; GTF2F2A; HSD3B6
Function formyltetrahydrofolate dehydrogenase activity
Related Protein ALDH1L2; ALDH1L1
Function hydroxymethyl-, formyl- and related transferase activity
Related Protein ALDH1L1; ALDH1L2
Function methyltransferase activity
Related Protein NSUN5; SETD8A; SMYD2A; SETD9; FAM119B; METTL25; C20orf7; METTL10; COMTB; PRDM14

Interacting Protein

ALDH1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1L1.
SIRT4

ALDH1L1 Related Articles

Huang, J; Zhang, L; et al. Global Transcriptome Analysis of Peripheral Blood Identifies the Most Significantly Down-regulated Genes Associated with Metabolism Regulation in Klinefelter Syndrome. MOLECULAR REPRODUCTION AND DEVELOPMENT 82:17-25(2015).
Dinh, ML; Koppel, SJ; et al. DISTRIBUTION OF GLIAL CELLS IN THE AUDITORY BRAINSTEM: NORMAL DEVELOPMENT AND EFFECTS OF UNILATERAL LESION. NEUROSCIENCE 278:237-252(2014).