ALDH8A1 Protein, aldehyde dehydrogenase 8 family, member A1


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Official Full Name aldehyde dehydrogenase 8 family, member A1
Background This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
Synonyms ALDH8A1; aldehyde dehydrogenase 8 family, member A1; aldehyde dehydrogenase family 8 member A1; ALDH12; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein; DJ352A20.2; MGC138650; DKFZp779D2315
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH8A1-453H Recombinant Human ALDH8A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH8A1-502H Recombinant Human Aldehyde Dehydrogenase 8 Family, Member A1, GST-tagged E.coli GST
    Human ALDH8A1-503H Recombinant Human Aldehyde Dehydrogenase 8 Family, Member A1, His-tagged E.coli His
    Human ALDH8A1-8914HCL Recombinant Human ALDH8A1 293 Cell Lysate HEK293 N/A
    Human ALDH8A1-9565H Recombinant Human ALDH8A1, His-tagged E.coli His
    Mouse ALDH8A1-1534M Recombinant Mouse ALDH8A1 Protein Mammalian Cell His
    Zebrafish ALDH8A1-1264Z Recombinant Zebrafish ALDH8A1 Mammalian Cell His

    ALDH8A1 involved in several pathways and played different roles in them. We selected most pathways ALDH8A1 participated on our site, such as RA biosynthesis pathway, Signal Transduction, Signaling by Retinoic Acid, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH8A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RA biosynthesis pathway DHRS3; DHRS3A; CRABP1A; AKR1C21; RDH7; RDH10; CRABP1B; ALDH8A1; ADH8A; RDH14A
    Signal Transduction CLIP3; ARHGAP11A; PYY; PPEF1; ADM; RTN4; RIT2; KREMEN1; LPAR2A; OR2AP1
    Signaling by Retinoic Acid PDK2; ALDH8A1; RARGA; FABP11B; CRABP1A; CRABP2; DHRS3; PDK3B; CRABP2B; DHRS3A

    ALDH8A1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, retinal dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH8A1 itself. We selected most functions ALDH8A1 had, and list some proteins which have the same functions with ALDH8A1. You can find most of the proteins on our site.

    Function Related Protein
    aldehyde dehydrogenase (NAD) activity ALDH7A1; ALDH2; ALDH3B2; ALDH3A2B; ALDH8A1; ALDH5A1; ALDH3A1; ALDH4A1; ALDH16A1; ALDH9A1B
    retinal dehydrogenase activity AKR1B8; AKR1C6; Aldh1a7; ALDH8A1; ALDH1A3; ALDH1A1; AKR1C3; AKR1C4; AKR1B10

    ALDH8A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH8A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH8A1.


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