Recombinant Human ALDH8A1, His-tagged

• Cat.No.: ALDH8A1-9565H
• Product Overview: Recombinant Human ALDH8A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: C-term-352a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ALDH8A1 aldehyde dehydrogenase 8 family, member A1 [ Homo sapiens ]
• Official Symbol: ALDH8A1
• Synonyms: ALDH8A1; aldehyde dehydrogenase 8 family, member A1; aldehyde dehydrogenase family 8 member A1; ALDH12; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein; DJ352A20.2; MGC138650; DKFZp779D2315
• Gene ID: 64577
• mRNA Refseq: NM_001193480
• Protein Refseq: NP_001180409
• MIM: 606467
• UniProt ID: Q9H2A2
• Chromosome Location: 6q24.1-q25.1
• Function: oxidoreductase activity; retinal dehydrogenase activity