ALG2

This mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.

ALG2 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.

ALG2 regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG3 and ALG1.

A number of inhibitors have been developed that target ALG2 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.

The catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.

No studies have confirmed whether ALG2 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.

Although there are currently no studies demonstrating the function of ALG2 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.

ALG2 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.

Overexpression or knockout of ALG2 can negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.

This protein selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.

ALG2 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.

At present, there is no direct evidence that ALG2 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.

There is currently no direct evidence that ALG2 is associated with neurological diseases, but glycosylation plays a key role in nervous system development and function, so there may be a correlation with neurological diseases.

This gene contains 10 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.

ALG2 is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.

At present, there is no direct evidence that ALG2 mutations are directly related to some diseases, but glycosylation plays an important role in metabolism and disease development, so it may be related to related diseases.

The protein interacts with members of the glycosylase family such as ALG3, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.

There is no direct evidence that ALG2 is involved in the occurrence and development of metabolic diseases, but it may be associated with related metabolic diseases.