alkbh8
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  • Official Full Name
  • alkB, alkylation repair homolog 8
  • Synonyms
  • ALKBH8; alkB, alkylation repair homolog 8 (E. coli); alkylated DNA repair protein alkB homolog 8; MGC10235; AlkB homologue 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; S-adenosyl-L
Cat.#:ALKBH8-479HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALKBH8 Protein, GST-tagged
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Cat.#:ALKBH8-1560MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALKBH8 Protein
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Cat.#:ALKBH8-3274BTag:His
Source (Host):Mammalian CellsSpecies:Bovine
Product nameRecombinant Bovine ALKBH8, His-tagged
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Cat.#:ALKBH8-18HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALKBH8 lysate
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Involved Pathway

ALKBH8 involved in several pathways and played different roles in them. We selected most pathways ALKBH8 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
SETB; METTL14; HENMT1; AARS; CLP1; ZNF560; NR5A1B; ZNF213; TAF1D; ZNF333
tRNA modification in the nucleus and cytosol
TRMT11; LCMT2; QTRT1; WDR4; PUS1; ALKBH8; KIAA1456; MANEA; TP53RK; ADAT3
tRNA processing
TRMT12; LAGE3; TSEN2; ELAC2; PUS7; POP7; ZBTB8OS; PUS1; TSEN15; C2orf49

Protein Function

ALKBH8 has several biochemical functions, for example, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH8 itself. We selected most functions ALKBH8 had, and list some proteins which have the same functions with ALKBH8. You can find most of the proteins on our site.
Function
Related Protein
Function iron ion binding
Related Protein CYGB1; ALOX5B.2; HBG1; CYP1C2; ALOX15B; CYP24A1; CYP2W1; FAM125B; HIF1AN; CYP2AA7
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Related Protein JHDM1D; PHF8; HIF1AN; TYW5; EGLN3; KDM5A; P4HTM; ALKBH8; EGLN2; C14orf169
Function protein binding
Related Protein PEBP1; PRPF8; RNF43; SNIP1; ATF3; MLLT10; TMEM41A; GHR; PRDM4; HNRNPH2
Function tRNA (uracil) methyltransferase activity
Related Protein PRDM12; TRMT10B; METTL21A; PRDM11; FBLL1; TRMT10C; NDUFAF5; RNMTL1B; METTL23; DIMT1
Function tRNA binding
Related Protein FARS2; XPO5; EEF1A1; PSTK; TYW5; PTCD1; FDXACB1; TRMT1; MADD; NSUN2
Function zinc ion binding
Related Protein CPO; RABGGTB; ZNFL1; LDB3; MMP3; RNF170; ZFPL1; PDZRN4; RXRGB; ZDHHC3A

Interacting Protein

ALKBH8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH8.
TRMT112; HSP90AA1; CCNB1; TCP1; CCT6A; CCT5; CCT8; CCT4; CCT2; q59h77_human