ALKBH8
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Official Full Name
alkB, alkylation repair homolog 8
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Synonyms
ALKBH8; alkB, alkylation repair homolog 8 (E. coli); alkylated DNA repair protein alkB homolog 8; MGC10235; AlkB homologue 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; S-adenosyl-L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ALKBH8 involved in several pathways and played different roles in them. We selected most pathways ALKBH8 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | ZNF684;ZNF548;COX7C;ZNF266;ZNF286A;NR1I3;TBX5;FARS2;BRF2 |
| tRNA modification in the nucleus and cytosol | TRMT61A;CDKAL1;QTRTD1;TPRKB;TRMT44;TRMT6;TYW1;QTRT1;ADAT2 |
| tRNA processing | ADAT3;RPP14;PUS7;THG1L;TYW5;ALKBH8;TSEN54;TYW1;QTRTD1 |
ALKBH8 has several biochemical functions, for example, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH8 itself. We selected most functions ALKBH8 had, and list some proteins which have the same functions with ALKBH8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | ETHE1;CYP8B1;CYGB1;CYGB2;HBAD;ISCUB;CYP4V2;CYP4A12A;P3H2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | EGLN1;HIF1AN;PHF8;ALKBH8;KDM5B;KDM5BA;ALKBH5;ALKBH4;EGLN3 |
| protein binding | ATG3;DNAL4;C6;ZNF511;SPARC;NTS;HLX;CHID1;ACD |
| tRNA (uracil) methyltransferase activity | TRMT10C;METTL21A;METTL8;FAM86;PRDM13;FBLL1;TRMT10B;TRMT44;RNMTL1B |
| tRNA binding | TRMT11;SEPSECS;TRMU;CTU1;AARS2;TERT;TRMT1L;FARS2;EIF2A |
| zinc ion binding | ARIH1L;LMO7A;GTF2H2C;ADAM32;LTA4H;VAT1;HERC2;MEX3C;ADA |
ALKBH8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH8.
TRMT112; HSP90AA1; CCNB1; TCP1; CCT6A; CCT5; CCT8; CCT4; CCT2; q59h77_human
- Q&As
- Reviews
Q&As (16)
Ask a questionThe mutation of ALKBH8 gene is related to individual heredity, age, gender and so on.
Mutations in the ALKBH8 gene can be regulated and influenced by a healthy lifestyle.
There is currently no specific treatment for the ALKBH8 gene mutation, but treatments can be tailored to the symptoms that occur.
The ALKBH8 gene has been linked to breast cancer, neurological diseases and more.
Mutations in the ALKBH8 gene may affect the body's immunity, but the exact extent of the impact needs to be further studied.
The ALKBH8 gene may affect the immune system, but the specific mechanism needs to be further studied.
ALKBH8 gene is expressed in various tissues, including breast, ovary, kidney, brain and so on.
Mutations in the ALKBH8 gene may cause some genetic diseases.
Mutations in the ALKBH8 gene may lead to long-term health consequences that need to be studied further.
The expression of ALKBH8 gene may be related to cell apoptosis, DNA repair and other physiological processes.
The mutation of ALKBH8 gene may be inherited, and the specific inheritance mode needs to be further studied.
Mutations in the ALKBH8 gene can be diagnosed by methods such as gene sequencing.
The mutation of ALKBH8 gene may be related to environmental factors such as chemicals and radiation.
Mutation of ALKBH8 gene may cause damage to DNA repair, resulting in cell apoptosis obstruction, cell mutation and other problems.
Mutations in the ALKBH8 gene may affect fertility, but the exact extent needs to be further studied.
There is currently no specific cure for mutations in the ALKBH8 gene.
Customer Reviews (3)
Write a reviewGood stability and activity during long-term storage.
It is effective and safe in clinical treatment.
ALKBH8 is not structurally or functionally defective.
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