apex1
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  • Official Full Name
  • APEX nuclease (multifunctional DNA repair enzyme) 1
  • Background
  • Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
  • Synonyms
  • APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1
Cat.#:APEX1-27360THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, T7 -tagged
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Cat.#:APEX1-1538HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human APEX1 protein
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Cat.#:APEX1-2497HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, His tagged
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Cat.#:APEX1-45HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APEX1 protein, GST-tagged
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Cat.#:APEX1-46HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APEX1 protein, His-tagged
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Cat.#:APEX1-677HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APEX1 protein, GST-tagged
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Cat.#:APEX1-1765MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APEX1 Protein
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Cat.#:APEX1-17RTag:HIS
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rattus APEX1 Protein, His-tagged
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Cat.#:APEX1-713RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APEX1 Protein
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Cat.#:APEX1-353RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey APEX1 Protein, His-tagged
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Cat.#:APEX1-4100CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken APEX1
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Cat.#:APEX1-12593ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish APEX1
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Cat.#:APEX1-593HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX Nuclease 1
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Cat.#:APEX1-955HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, T7-tagged
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Cat.#:APEX1-8796HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APEX1 293 Cell Lysate
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Cat.#:APEX1-8797HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APEX1 293 Cell Lysate
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Involved Pathway

APEX1 involved in several pathways and played different roles in them. We selected most pathways APEX1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
POLD1; NEIL2; xthA; PNKP; XRCC1; MPG; HMGB1B; APEX2; OGG1; MUTYH

Protein Function

APEX1 has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX1 itself. We selected most functions APEX1 had, and list some proteins which have the same functions with APEX1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein POLE; ERI1; TREX1; RAD1; WRN; RAD9A; MRE11A; EXD1; EXD2; APEX1
Function DNA binding
Related Protein KLF8; HIST1H110; HES7; ZNF358; ZNF224; SOX21; SUB1B; TBX1; MKXB; RARGB
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein ALKBH1; HMGA2; APEX2; NEIL3; NEIL1; NTHL1; APEX1; APLF; HMGA1-RS1; HMGA1
Function RNA-DNA hybrid ribonuclease activity
Related Protein FEN1; APEX1; RNASEH1; RNASEH2B; RNASEH2A; RNASEH2C; EXO1
Function chromatin DNA binding
Related Protein NOTCH1; ATOH1; H2AFZ; RELA; ZIC2; SRF; VAX1; H2AFY; HDAC3; MYOD1
Function damaged DNA binding
Related Protein ERCC3; CRY2; POLI; RAD1; MPG; BRCA1; RAD23B; TP73; CREBBP; FEN1
Function double-stranded DNA 3-5 exodeoxyribonuclease activity
Related Protein APEX2; APEX1
Function endodeoxyribonuclease activity
Related Protein DNASE1L2; DNASE1L3L; DNASE1L3; APEX1; DNASE1L1; ERCC4; DNASE2A; DNASE1; ERCC5; APLF
Function endonuclease activity
Related Protein DCLRE1C; EME2; SMG6; EAR4; DROSHA; ZRANB3; RAG1; RNASE4; SETMAR; CENPT
Function metal ion binding
Related Protein ZFP503; ZNF649; AGO2; NR5A5; TRIT1; ZNF444; COL27A1; SALL1A; TPP1; CPEB1
Function oxidoreductase activity
Related Protein CYP46A1.4; GULO; DHRS3A; ADOA; CYP51; BCO2L; SPRB; H2-KE6; GPX1A; ADH8B
Function phosphodiesterase I activity
Related Protein ENPP1; ENPP2; FAN1; APEX1
Function phosphoric diester hydrolase activity
Related Protein PLCD1B; PLCD1A; ENPP6; PLCXD1; PLCXD3; PLCH2; PDE5AB; MPPE1; PLCXD2; PLCD3A
Function poly(A) RNA binding
Related Protein SAMD4; TBL3; TPT1; PABPN1; KHDRBS1; MSI2; FAM46A; ZC3H10; LSM4; EIF4ENIF1
Function protein binding
Related Protein RCHY1; NR2C1; MPHOSPH6; AMOTL2A; RAD23A; ZNF302; MKI67; COPG; JDP2; C8orf48
Function site-specific endodeoxyribonuclease activity, specific for altered base
Related Protein DNA2; APEX1
Function transcription coactivator activity
Related Protein MTF1; USP22; NFATC4; USP16; KAT5; YAP1; TAF10; PQBP1; TRIM24; POU2AF1
Function transcription corepressor activity
Related Protein NR0B2; ZHX1; CDX2; MYBBP1A; ZHX3; NR0B1; TGIF1; HIPK2; SKOR2; GMNN
Function uracil DNA N-glycosylase activity
Related Protein TDG; UNG; TDG.1; SMUG1; APEX1; CCNO; UNGA

Interacting Protein

APEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX1.
EP300; HSPA1A; SIRT1; mdm2_human_probe; SRPK2