apex1
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  • Official Full Name
  • APEX nuclease (multifunctional DNA repair enzyme) 1
  • Background
  • Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
  • Synonyms
  • APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1
Cat.#:APEX1-27360THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, T7 -tagged
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Cat.#:APEX1-1538HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human APEX1 protein
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Cat.#:APEX1-2497HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, His tagged
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Cat.#:APEX1-45HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APEX1 protein, GST-tagged
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Cat.#:APEX1-46HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APEX1 protein, His-tagged
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Cat.#:APEX1-677HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APEX1 protein, GST-tagged
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Cat.#:APEX1-1765MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APEX1 Protein
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Cat.#:APEX1-17RTag:HIS
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rattus APEX1 Protein, His-tagged
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Cat.#:APEX1-713RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APEX1 Protein
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Cat.#:APEX1-353RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey APEX1 Protein, His-tagged
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Cat.#:APEX1-4100CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken APEX1
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Cat.#:APEX1-12593ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish APEX1
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Cat.#:APEX1-593HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX Nuclease 1
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Cat.#:APEX1-955HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APEX1, T7-tagged
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Cat.#:APEX1-8796HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APEX1 293 Cell Lysate
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Cat.#:APEX1-8797HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APEX1 293 Cell Lysate
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Involved Pathway

APEX1 involved in several pathways and played different roles in them. We selected most pathways APEX1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
XRCC1; APEX1; POLD4; MUTYH; TDG; PARP4; FEN1; POLD1; MPG; UNGA

Protein Function

APEX1 has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX1 itself. We selected most functions APEX1 had, and list some proteins which have the same functions with APEX1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein EXD1; TREX1; RAD9B; POLG; WRN; MRE11A; RAD9A; RAD9; POLA1; ERI1
Function DNA binding
Related Protein PAX2A; ARNTL2; ABL1; NR1D1; ZNF131; TFDP1A; ARNTL1B; GIN1; ENG2B; PKNOX1.1
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein HMGA1A; APEX2; ALKBH1; HMGA1B; NTHL1; RPS3; HMGA1; NEIL2; HMGA1-RS1; APEX1
Function RNA-DNA hybrid ribonuclease activity
Related Protein APEX1; RNASEH2A; RNASEH1; FEN1; EXO1; RNASEH2C; RNASEH2B
Function chromatin DNA binding
Related Protein VAX2; PPARGC1A; HIST1H1D; GRHL3; AASS; GRHL1; RUVBL2; HIST1H1E; EP300; H2AFZ
Function damaged DNA binding
Related Protein POLK; TP63; POLI; TDG; RAD23AA; OGG1; CRY2; TRPC2; RAD23A; NEIL3
Function double-stranded DNA 3-5 exodeoxyribonuclease activity
Related Protein APEX2; APEX1
Function endodeoxyribonuclease activity
Related Protein DNASE1L3L; DNASE2A; MRE11A; ERCC5; ERCC4; DNASE1L3; DNASE1L1; ZRANB3; APLF; RPS3
Function endonuclease activity
Related Protein SMG6; EAR5; ANG4; RNASE2; RNASEKB; MRE11A; ANG; EAR2; ANG3; PNKP
Function metal ion binding
Related Protein TERT; DOM3Z; CYP2D10; ZNF511; PRICKLE2A; HBBE2; ATP2A2A; OSGEP; MOCS3; PPP6C
Function oxidoreductase activity
Related Protein MTO1; SDR39U1; KDM5BB; RDH13; GPX4B; ALDH3A2A; CYP2C50; HSD3B6; DAO.2; FDFT1
Function phosphodiesterase I activity
Related Protein ENPP2; FAN1; APEX1; ENPP1
Function phosphoric diester hydrolase activity
Related Protein PLCD1A; MPPE1; PLCH2; PLCXD2; PLCD3A; APEX1; ENPP6; PLCXD1; PDE5AB; PLCXD3
Function poly(A) RNA binding
Related Protein SLIRP; CCT6A; IFI203; BRIX1; MRPS31; RPL36; Api5; MANF; DHX36; PES1
Function protein binding
Related Protein SLC1A5; PRELID1; PPHLN1; KCNQ4; CRB3; GLRX3; ZBTB7A; SPINK1; BTK; FANCD2
Function site-specific endodeoxyribonuclease activity, specific for altered base
Related Protein APEX1; DNA2
Function transcription coactivator activity
Related Protein RNF20; MYSM1; NR5A1; MED12; MED31; BRD7; TRIP4; NFE2L3; MTF1; NR1H3
Function transcription corepressor activity
Related Protein LOXL2; RBFOX2; LDB1; HIRA; SKIL; SSX1; IRF2BP2; LHX1A; CBFA2T2; MTA1
Function uracil DNA N-glycosylase activity
Related Protein TDG.1; UNGA; CCNO; SMUG1; TDG; UNG; APEX1

Interacting Protein

APEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX1.
EP300; HSPA1A; SIRT1; mdm2_human_probe; SRPK2