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APOA2

  • Official Full Name

    apolipoprotein A-II

  • Overview

    This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
  • Synonyms

    APOA2; apolipoprotein A-II; apoAII; Apo-AII; ApoA-II; apolipoprotein A2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Human Cell
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOA2-691H Recombinant Human APOA2 protein, GST-tagged Wheat Germ GST
Human APOA2-9748H Recombinant Human APOA2, GST-tagged E.coli GST 1-100a.a.
Human APOA2-2642H Recombinant Human APOA2 protein, His & GST-tagged E.coli His/GST Gln24~Gln100 (Accession # P02652)
Human APOA2-95H Recombinant Human APOA2, His-tagged Human Cell His
Human APOA2-915H Recombinant Human APOA2 Protein, GST-His-tagged E.coli GST/His
Human APOA2-8789HCL Recombinant Human APOA2 293 Cell Lysate HEK293 N/A
Human APOA2-608H Native Human Apolipoprotein A-II Human Plasma N/A
Human APOA2-4772H Native Human Apolipoprotein AII protein Human Plasma N/A
Human APOA2-194H Recombinant Human APOA2 protein, His-tagged E.coli His 89aa
Human ApoA-II-3555H Native Human ApoA-II Human plasma N/A
Human APOA2-357H Recombinant Human APOA2 protein, His-tagged E.coli His 82
Human ApoC-II-3558H Native Human ApoC-II Human plasma N/A
Human APOA2-3331H Recombinant Human APOA2 protein, His-SUMO-tagged E.coli His-SUMO Gln24~Gln100
Human APOA2-8036H Native Human ApoLipoprotein APOA2 Human Plasma N/A
Human APOA2-0300H Recombinant Human APOA2 Protein (Gln24-Gln100), C-His-tagged Mammalian cells C-His Gln24-Gln100
Human APOA2-1112HF Recombinant Full Length Human APOA2 Protein, GST-tagged In Vitro Cell Free System GST 100 amino acids
Human APOA2-0301H Recombinant Human APOA2 Protein (Gly18-Gln100), N-SUMO-tagged E.coli N-SUMO Gly18-Gln100
Human APOA2-0302H Recombinant Human APOA2 Protein, Tag Free E.coli Tag Free
Mouse APOA2-1781M Recombinant Mouse APOA2 Protein Mammalian Cell His
Mouse Apoa2-18M Recombinant Mouse Apoa2, GST-tagged Wheat Germ GST
Mouse Apoa2-209M Recombinant Mouse Apoa2 Protein, His-tagged E.coli N-His Gln24-Lys102
Mouse APOA2-627M Recombinant Mouse APOA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Apoa2-207M Recombinant Mouse Apoa2 Protein, His-tagged CHO N-His Gln24-Lys102
Mouse APOA2-627M-B Recombinant Mouse APOA2 Protein Pre-coupled Magnetic Beads HEK293
Rat Apoa2-2644R Recombinant Rat Apoa2 protein, His & GST-tagged E.coli His/GST Gln24~Lys102 (Accession # P04638)
Rat APOA2-718R Recombinant Rat APOA2 Protein Mammalian Cell His
Rat Apoa2-3566R Recombinant Rat Apoa2, GST-tagged E.Coli or Yeast GST 102
Rat APOA2-374R-B Recombinant Rat APOA2 Protein Pre-coupled Magnetic Beads HEK293
Rat APOA2-374R Recombinant Rat APOA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog APOA2-208D Recombinant Dog APOA2 Protein, His&GST-tagged E.coli N-His&GST Gln24-Gln100
Zebrafish APOA2-7070Z Recombinant Zebrafish APOA2 Mammalian Cell His
Pig APOA2-2643P Recombinant Pig APOA2 protein, His & GST-tagged E.coli His/GST Ala19~Gln100 (Accession # F1S1A9)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOA2 Related Articles
  • APOA2 Related Research Area

APOA2 involved in several pathways and played different roles in them. We selected most pathways APOA2 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayCYP7A1A;ACSBG1;ACSL4A;ADIPOQ;ADIPOQB;ACSL4;CYP4A14;PDPK1B;DBI

APOA2 has several biochemical functions, for example, apolipoprotein receptor binding, cholesterol binding, contributes_to cholesterol transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA2 itself. We selected most functions APOA2 had, and list some proteins which have the same functions with APOA2. You can find most of the proteins on our site.

Function Related Protein
apolipoprotein receptor bindingAPOA1;APOA2;PCSK9
cholesterol bindingAPOA2;OSBPL1A;OSBPL5;APOA4;ERLIN2;STARD6;STAR;APOA4A;ABCG1
contributes_to cholesterol transporter activityABCG5;ABCG8;APOA2;SFRP5;APOA1
high-density lipoprotein particle bindingAPOA2;GPIHBP1;APOL2;APOA1;APOA1A
high-density lipoprotein particle receptor bindingAPOA1;APOA2;APOC3
lipase inhibitor activityAPOC2;APOA1;APOC1;APOA2;FAF2;APOC3
lipid bindingCOQ9;BAIAP2L2B;PLEKHA2;ACOT11B;MARK2;CRABP2B;FABP10A;FAM123C;ACBD7
lipid transporter activityVTG5;ATP8B1;GM2A;VTG1;APOL3;APOM;APOE;APOD;VTG2
phosphatidylcholine bindingRPE65;APOA1A;RASGRP1;PCTP;CHMP3;APOA2;NF1;CHMP2A;CETP
phosphatidylcholine-sterol O-acyltransferase activator activityAPOEA;APOA4B.2;APOA4;APOC1;APOA1A;APOA1;APOEB;APOA4A;APOA4B.1
phospholipid bindingAPOC3;APOM;PLA2G7;PLEKHA3;SPTB;CPS1;LRBA;APOE;DGKA
protein bindingMYO5B;KCNK16;MCC;VPS4B;AGFG1;PPP1R12C;ELN;CCDC155;BCL2L13
protein heterodimerization activityADD2;UGT1A9;RXRA;TPD52L1;ITGA3;VOX;Pdgfa&Pdgfb;TYRP1;SYT5
protein homodimerization activityCRYAB;ECE1;CBX5;ANXA1;MID2;IGJ;PSMD7;PVRL1A;TNNC1

APOA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA2.

CATSPER1; CREB3; p27958-pro_0000037566; d-mannose; APOE; APOC2; ALB; APOB

Chen, HC; Chen, YT; et al. A sensitive and selective magnetic graphene composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis. BIOSENSORS & BIOELECTRONICS 66:198-207(2015).
Chen, CL; Lin, TS; et al. Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics. JOURNAL OF PROTEOMICS 85:28-43(2013).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
Are there any known genetic variations or polymorphisms associated with APOA2? 07/30/2022

Yes, there are known genetic variations and polymorphisms associated with APOA2. One well-studied single nucleotide polymorphism (SNP) in the APOA2 gene is rs5082, also known as the APOA2 -265T>C polymorphism. This polymorphism has been associated with differences in HDL cholesterol levels and the risk of cardiovascular disease.

How is APOA2 regulated at the gene expression level? 07/17/2022

The regulation of APOA2 gene expression is complex and involves several molecular mechanisms. Transcription factors, such as hepatocyte nuclear factor 4 alpha (HNF4α) and forkhead box O1 (FOXO1), have been implicated in controlling APOA2 expression. Additionally, epigenetic modifications, including DNA methylation and histone acetylation, can influence APOA2 gene expression. Further studies are necessary to fully understand the regulatory mechanisms governing APOA2 expression.

Can genetic variations in APOA2 predict individual responses to specific diets or therapies? 07/30/2021

It is possible that genetic variations in APOA2 may predict individual responses to certain diets or therapies. Studies have suggested that specific APOA2 polymorphisms could influence an individual's response to dietary interventions, particularly in terms of weight management and lipid profiles. However, further research is needed to understand and validate these associations before they can be routinely applied in personalized medicine.

Are there any associations between APOA2 and obesity? 01/26/2021

Yes, studies have shown associations between certain genetic variations in APOA2 and obesity. The APOA2 -265T>C polymorphism, for example, has been found to be associated with obesity-related traits and increased appetite in some populations.

Does APOA2 play a role in appetite regulation? 01/18/2021

Yes, APOA2 has been implicated in appetite regulation. Certain genetic variations in APOA2, such as the APOA2 -265T>C polymorphism, have been associated with increased appetite and higher caloric intake, particularly in the context of high-fat diets.

Are there any diseases or conditions associated with APOA2 abnormalities? 11/19/2020

Abnormalities or variations in APOA2 have been associated with various diseases and conditions. For example, certain genetic variations in APOA2 have been linked to an increased risk of obesity, dyslipidemia, and cardiovascular diseases. Additionally, impaired APOA2 function or expression has been observed in some liver diseases and metabolic disorders.

Can APOA2 levels be influenced by lifestyle factors? 11/10/2020

Lifestyle factors, such as diet and physical activity, can influence APOA2 levels. High intake of saturated fats, as well as certain other dietary factors, can upregulate APOA2 expression, while healthier dietary patterns and increased physical activity can downregulate its expression.

Are there any known interactions between APOA2 and other proteins or lipoproteins? 06/30/2020

APOA2 interacts with several other proteins and lipoproteins in the body. It forms complexes with apolipoprotein A-I (APOA1) to constitute high-density lipoprotein (HDL) particles. APOA2 can also interact with other lipoproteins, such as apolipoprotein B (APOB) and apolipoprotein E (APOE), which are associated with other lipoprotein subclasses. These interactions play a crucial role in lipid metabolism and transportation.

How does APOA2 affect lipid metabolism? 12/19/2019

APOA2 influences lipid metabolism by regulating the metabolism of HDL particles. It modulates HDL particle size, and its interactions with other proteins and lipids within the HDL particle affect its ability to participate in processes such as cholesterol efflux and reverse cholesterol transport.

Can APOA2 levels be measured in clinical settings? 04/15/2019

Yes, APOA2 levels can be measured in clinical settings. Laboratory tests, such as enzyme-linked immunosorbent assays (ELISA) and immunoassays, are commonly used to quantify APOA2 protein levels in blood samples. Measuring APOA2 levels can provide insights into lipid metabolism and may be useful in evaluating certain disease risks or monitoring treatment response.

How is the APOA2 protein produced? 10/02/2018

The APOA2 protein is synthesized through the process of translation. The APOA2 gene, located on chromosome 1, is transcribed into messenger RNA (mRNA) in the cell nucleus. The mRNA then moves to the cytoplasm, where ribosomes read the genetic code and synthesize the APOA2 protein by linking amino acids together.

Can APOA2 levels be affected by lifestyle factors? 02/02/2018

Yes, lifestyle factors can influence APOA2 levels. Multiple studies have shown that dietary intake, exercise, and lifestyle choices can impact APOA2 expression and lipid metabolism. For example, a high-fat diet has been shown to increase APOA2 levels, while weight loss and physical activity may lead to a decrease in APOA2 levels.

Are there any drugs or interventions that specifically target APOA2 for therapeutic purposes? 01/21/2018

Currently, there are no drugs or interventions that specifically target APOA2 for therapeutic purposes. Most therapeutic strategies aimed at improving lipid metabolism and reducing cardiovascular risk focus on modulating lipid levels or targeting other lipoproteins. However, ongoing research exploring the role of APOA2 may lead to the development of novel therapeutic approaches in the future.

Are there any therapeutic interventions targeting APOA2 being developed? 05/17/2017

Currently, there are no specific therapeutic interventions targeting APOA2 available. However, ongoing research aims to understand the role of APOA2 in lipid metabolism and explore potential therapeutic strategies for cardiovascular diseases and obesity that may involve modulating its expression or function.

Can APOA2 levels be modified or manipulated through pharmacological interventions? 01/13/2017

Currently, there are no specific pharmacological interventions available to directly modify or manipulate APOA2 levels. However, certain drugs, such as statins and fibrates, commonly used to treat dyslipidemia, can indirectly affect APOA2 levels by influencing lipid metabolism and overall lipoprotein composition. Additionally, emerging research may identify potential pharmacological targets that can directly modulate APOA2 levels in the future.

Are there any potential diagnostic or therapeutic applications for APOA2 in the future? 01/10/2017

The study of APOA2 and its implications in various diseases and conditions may lead to potential diagnostic and therapeutic applications in the future. Understanding APOA2's role in lipid metabolism, obesity, and cardiovascular diseases could help in developing improved diagnostic tools and personalized treatment approaches. Additionally, targeting APOA2 or its related pathways may offer new therapeutic strategies for managing metabolic disorders and cardiovascular risk factors. However, further research is needed to validate these possibilities.

Does APOA2 have any dietary regulation? 03/30/2016

Yes, the expression of the APOA2 gene is influenced by dietary factors, particularly the intake of saturated fats. High intake of saturated fats can upregulate APOA2 expression, while diets rich in unsaturated fats or polyunsaturated fats can downregulate its expression.

What are the functions of APOA2 outside of lipid metabolism? 01/12/2016

While APOA2 is primarily known for its role in lipid metabolism, recent studies have suggested that it may have additional functions. It has been implicated in modulating inflammatory responses and exerting antioxidant effects. However, the exact mechanisms and significance of these additional functions are still being investigated.

Customer Reviews (4)

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Reviews
01/04/2023

    I have successfully implemented the APOA2 protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

    05/06/2022

      when utilized in Western Blotting experiments, the APOA2 protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

      02/04/2021

        The APOA2 protein comes highly recommended for its outstanding performance in various experimental applications.

        06/21/2020

          In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

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