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AQP1

  • Official Full Name

    aquaporin 1 (Colton blood group)

  • Synonyms

    AQP1; aquaporin 1 (Colton blood group); aquaporin 1 (channel forming integral protein, 28kDa) , aquaporin 1 (channel forming integral protein, 28kDa, CO blood group) , CO, Colton blood group; aquaporin-1; CHIP28; aquaporin-CHIP; Colton blood group; urin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Medicago truncatula (Barrel medic) (Medicago tribuloides)
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • His|T7
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP1-732H Recombinant Human AQP1 protein, GST-tagged Wheat Germ GST
Human AQP1-3592H Recombinant Human AQP1, His-tagged, GST-tagged E.coli His/GST 186
Human AQP1-1130H Recombinant Human AQP1 Protein, His-SUMO-tagged E.coli His/SUMO
Human AQP1-9779H Recombinant Human AQP1, GST-tagged E.coli GST C-term-50a.a.
Human AQP1-8770HCL Recombinant Human AQP1 293 Cell Lysate HEK293 N/A
Human AQP1-1155HF Recombinant Full Length Human AQP1 Protein, GST-tagged In Vitro Cell Free System GST 269 amino acids
Human AQP1-0193H Recombinant Human AQP1 Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 2-269aa
Human AQP1-1221HFL Recombinant Full Length Human AQP1 Protein, C-Flag-tagged Mammalian cells Flag
Human AQP1-367H Recombinant Human AQP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AQP1-367H-B Recombinant Human AQP1 Protein Pre-coupled Magnetic Beads HEK293
Human AQP1-0387H Recombinant Human AQP1 Protein (Val201-Lys269), N-GST-tagged E.coli N-GST Val201-Lys269
Human AQP1-115H Recombinant Human AQP1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 2-269aa
Mouse AQP1-1818M Recombinant Mouse AQP1 Protein Mammalian Cell His
Mouse AQP1-646M Recombinant Mouse AQP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AQP1-646M-B Recombinant Mouse AQP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Aqp1-1670M Recombinant Mouse Aqp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Aqp1-3595R Recombinant Rat Aqp1, His-tagged E.Coli or Yeast His 269
Rat AQP1-735R Recombinant Rat AQP1 Protein Mammalian Cell His
Rat AQP1-391R-B Recombinant Rat AQP1 Protein Pre-coupled Magnetic Beads HEK293
Rat Aqp1-233R Recombinant Rat Aqp1 Protein, His&GST-tagged E.coli N-His&GST Ile184-Lys269
Rat AQP1-391R Recombinant Rat AQP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit AQP1-2601R Recombinant Rabbit AQP1 protein, His & T7-tagged E.coli His/T7 Val78~Phe229 (Accession# G1TN20)
Bos taurus (Bovine) RFL-27377BF Recombinant Full Length Bovine Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Canis lupus familiaris (Dog) (Canis familiaris) RFL21092CF Recombinant Full Length Dog Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Homo sapiens (Human) RFL-19910HF Recombinant Full Length Human Aquaporin-1(Aqp1) (Active) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-269aa)
Medicago truncatula (Barrel medic) (Medicago tribuloides) RFL18524MF Recombinant Full Length Medicago Truncatula Probable Aquaporin Tip-Type(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-250)
Milnesium tardigradum (Water bear) (Tardigrade) RFL29573MF Recombinant Full Length Milnesium Tardigradum Aquaporin-1(Aqp1) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-333)
Mus musculus (Mouse) RFL24916MF Recombinant Full Length Mouse Aquaporin-1(Aqp1) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-269)
Ovis aries (Sheep) RFL-33528OF Recombinant Full Length Sheep Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-272)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL30577PF Recombinant Full Length Pongo Abelii Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-269)
Rattus norvegicus (Rat) RFL-8445RF Recombinant Full Length Rat Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-269)
Sus scrofa (Pig) RFL12600SF Recombinant Full Length Pig Aquaporin-1(Aqp1) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Chicken AQP1-3387C Recombinant Chicken AQP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQP1 Related Articles
  • AQP1 Related Research Area

AQP1 involved in several pathways and played different roles in them. We selected most pathways AQP1 participated on our site, such as Renin secretion, Proximal tubule bicarbonate reclamation, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Renin secretionGNAS;REN;GNAQ;PRKACG;PPP3CB;GNAI2;ACE;PPP3R2;GUCY1A3
Proximal tubule bicarbonate reclamationATP1A3;ATP1A1;CA4;GLUD2;SLC38A3;PCK2;AQP1;GLUD1;Car4
Bile secretionKCNN2;HMGCR;SLC10A2;SLC9A3;SLCO1A6;RXRA;SLC4A4;SLC22A7;SLC2A1

AQP1 has several biochemical functions, for example, ammonium transmembrane transporter activity, carbon dioxide transmembrane transporter activity, glycerol channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP1 itself. We selected most functions AQP1 had, and list some proteins which have the same functions with AQP1. You can find most of the proteins on our site.

Function Related Protein
ammonium transmembrane transporter activityRHCGB;AQP1A.2;RHCGL1;RHD;RHBG;RHCGA;RH50;RHAG;RHCE
carbon dioxide transmembrane transporter activityAQP1;AQP1A.1;AQP1A.2
glycerol channel activityAQP8A.1;AQP3B;AQP1A.2;AQP9B;MIPB;AQP2;AQP8A.2;AQP10A;AQP8B
glycerol transmembrane transporter activityAQP3B;AQP10B;AQP10A;AQP1;AQP9A;AQP9B;AQP3A;AQP2
intracellular cGMP activated cation channel activityCNGA5;CNGA3;CNGA4;CNGA1;AQP1;CNGA2
nitric oxide transmembrane transporter activity
potassium channel activityTRPM5;KCNK4;KCNB2;KCNK3;KCNK7;KCNK10B;KCNK16;KCNC3B;KCNF1A
potassium ion transmembrane transporter activityAQP1;KCNA1
protein bindingLURAP1;DCUN1D4;HBA2;EFCAB4B;SAP30BP;PSMB4;CFL1;APEX1;RBM23
transmembrane transporter activityRALBP1;ATP5C1;SV2A;SLC2A11L;SV2B;SLC2A9L1;ATP5J;ATP5E;SLC22A1
water channel activityAQP9B;AQP9;AQP10A;MIP;AQP3B;AQP6;AQP7;AQP8A.2;AQP2
water transmembrane transporter activityAQP1;AQP9;AQP8A.1;AQP1A.2;AQP1A.1;SLC14A1;AQP10A;AQP2;AQP10B

AQP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP1.

MDFI; TRIP6; FSD2; SPRY2

Tsai, MC; Lin, HJ; et al. High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning. JOURNAL OF TRAUMA AND ACUTE CARE SURGERY 77:585-591(2014).
Tran, TL; Bek, T; et al. Altered aquaporin expression in glaucoma eyes. APMIS 122:772-780(2014).
  • Q&As
  • Reviews

Q&As (29)

Ask a question
Are there any diseases associated with AQP1 dysfunction? 09/10/2022

Yes, AQP1 dysfunction has been associated with various diseases and conditions. For example, mutations in the AQP1 gene have been linked to hereditary recessive foveal hypoplasia, which is characterized by impaired water transport in the retina. Additionally, AQP1 has been implicated in the development and progression of conditions like acute respiratory distress syndrome (ARDS), cerebral edema, and kidney disorders.

Are there any drugs or inhibitors targeting AQP1? 08/28/2022

Currently, there are no FDA-approved drugs or specific inhibitors targeting AQP1. However, there is ongoing research towards the development of AQP1 modulators and blockers that could potentially be used for therapeutic purposes.

Can AQP1 play a role in cancer progression? 07/05/2022

Yes, AQP1 has been implicated in cancer progression and metastasis in certain types of cancer. It has been shown to be upregulated in various cancer cells, including colorectal, lung, and breast cancer cells. AQP1 has been suggested to promote tumor angiogenesis, invasion, and migration by facilitating water and ion transport across cell membranes. However, the exact mechanisms by which AQP1 contributes to cancer progression are still being studied.

Does AQP1 have any physiological roles other than water transport? 06/23/2022

Yes, apart from its role in water transport, AQP1 has been implicated in other physiological processes. For example, it has been suggested to play a role in cell migration and angiogenesis, as well as in the regulation of endothelial cell function and blood vessel permeability.

Can genetic mutations in the AQP1 gene cause any specific diseases? 04/26/2022

Yes, mutations in the AQP1 gene can lead to various diseases or conditions. One example is the deficiency of AQP1 in red blood cells, which can result in hereditary stomatocytosis, a rare condition characterized by abnormal red blood cell shape and reduced cell flexibility. Other AQP1 mutations have been associated with hydrocephalus, a condition characterized by the accumulation of cerebrospinal fluid in the brain.

Can AQP1 be found in the respiratory system? 02/06/2022

Yes, AQP1 is expressed in the respiratory system, specifically in the alveolar cells of the lungs. It helps in the transport of water across the alveolar epithelium, contributing to the proper humidification of inhaled air and the maintenance of lung function.

Can AQP1 be targeted for therapeutic purposes? 12/08/2021

The role of AQP1 in various diseases has sparked interest in targeting the protein for therapeutic purposes. Modulating AQP1 expression or activity may hold promise for treating conditions involving fluid imbalances, such as renal disorders, edema, and certain cancers. However, further research is needed to develop specific pharmacological approaches targeting AQP1.

Is AQP1 regulated by any factors? 11/18/2021

Yes, AQP1 expression and activity can be regulated by various factors. For example, water deprivation, osmotic gradients, hormone signaling, and changes in intracellular calcium levels can all influence AQP1 expression and cellular localization, thereby modulating its water transport capacity.

Are there any factors that can downregulate the expression or activity of AQP1? 09/12/2021

Several factors can downregulate the expression or activity of AQP1. For instance, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) can decrease AQP1 expression in various tissues. Additionally, certain drugs or chemical agents, such as mercury and cadmium, have been shown to inhibit AQP1 activity.

Are there any known AQP1 polymorphisms associated with diseases? 08/28/2021

Yes, certain polymorphisms or variations in the AQP1 gene have been identified and associated with specific diseases or conditions. For example, a single nucleotide polymorphism (SNP) known as AQP1-732C > T has been linked to increased risk of primary open-angle glaucoma. Other AQP1 polymorphisms have been studied in relation to conditions like diabetic retinopathy and essential hypertension, although more research is still needed to establish clear associations.

Is AQP1 involved in the regulation of fluid balance in the body? 08/08/2021

Yes, AQP1 plays a crucial role in the regulation of fluid balance in the body. It is involved in the reabsorption of water from various body fluids, including urine in the kidneys and respiratory secretions in the lungs. By facilitating water transport across cell membranes, AQP1 helps maintain proper hydration levels and fluid homeostasis.

Is AQP1 involved in the maintenance of fluid balance in the eye? 05/13/2021

Yes, AQP1 plays a vital role in maintaining fluid balance in the eye. It is expressed in the ciliary body and epithelium of the lens, where it facilitates the movement of water, ions, and nutrients, helping to maintain proper intraocular pressure and transparency of the lens.

Are there any known inhibitors or activators of AQP1? 03/14/2021

Several inhibitors of AQP1 have been identified and tested in preclinical studies. These include small molecule inhibitors like mercury-based compounds (such as HgCl2) and arylsulfonamide derivatives. These inhibitors can block the water transport activity of AQP1 and have been explored for their potential therapeutic use, particularly in cancer. However, further studies are needed to determine their efficacy and safety in clinical settings. There are currently no known activators of AQP1, as its activity is mainly regulated by other factors like hormonal and cellular signaling pathways.

Is AQP1 involved in the regulation of cell volume? 01/10/2021

Yes, AQP1 plays a role in the regulation of cell volume. By facilitating the movement of water across cell membranes, AQP1 helps maintain cell hydration and prevents excessive swelling or shrinkage of cells in response to changes in osmolarity or osmotic stress.

Does AQP1 have any role in the central nervous system? 11/10/2020

Yes, AQP1 has been detected in certain regions of the central nervous system (CNS), including the choroid plexus and ependymal cells. It is involved in the regulation of cerebrospinal fluid (CSF) formation and circulation. AQP1 allows for the movement of water across the blood-brain barrier, aiding in the exchange of water and solutes between the blood and the CNS.

Can AQP1 be targeted for therapeutic purposes? 01/25/2020

The role of AQP1 in various diseases and its involvement in water transport make it an attractive target for therapeutic purposes. Several research studies have explored the use of AQP1 inhibitors, antibodies, or gene therapy approaches to modulate its function and potentially treat conditions such as cancer, brain edema, and certain kidney disorders. However, further studies are needed to determine the efficacy and safety of such therapeutic approaches.

Can AQP1 transport substances other than water? 08/19/2019

While AQP1 primarily transports water, it can also facilitate the movement of small solutes such as urea, glycerol, and certain gases (e.g., carbon dioxide and nitric oxide). These molecules can pass through the narrow pore of AQP1 by a process called "paracellular permeability."

Are there any known diseases associated with AQP1 dysfunction? 05/16/2019

Yes, mutations or alterations in AQP1 have been implicated in several diseases. For instance, mutations in the AQP1 gene can lead to abnormalities in urinary concentration and renal function, resulting in conditions like nephrogenic diabetes insipidus. AQP1 dysregulation has also been implicated in diseases such as lung edema, brain edema, and certain types of cancer.

Are there any known interacting partners or regulators of AQP1? 12/06/2018

AQP1 can interact with other proteins or molecules to modulate its function. For example, AQP1 has been reported to interact with caveolin-1, an integral component of caveolae, to regulate its cellular localization and trafficking. Additionally, phosphorylation events mediated by protein kinases can modulate AQP1 activity and cellular responses in various tissues.

Are there any therapeutic implications of targeting AQP1? 09/14/2018

Yes, targeting AQP1 has shown potential therapeutic implications in various diseases. For instance, in cancer, inhibiting AQP1 has been explored as a strategy to inhibit tumor angiogenesis and metastasis. In kidney disorders, modulating AQP1 expression or activity may help regulate fluid balance and alleviate symptoms associated with disorders like polycystic kidney disease or nephrogenic diabetes insipidus. Additionally, targeting AQP1 in conditions like cerebral edema and acute respiratory distress syndrome (ARDS) may help reduce fluid accumulation and improve patient outcomes.

Can AQP1 expression be regulated by hormones? 09/03/2018

Yes, AQP1 expression can be regulated by hormones. For instance, in the kidney, the antidiuretic hormone vasopressin (ADH) can stimulate the translocation and insertion of AQP1 into the cell membrane, increasing water reabsorption. Similarly, hormonal regulation of AQP1 expression has been observed in other tissues, such as the respiratory epithelium.

Are there any other isoforms of aquaporin proteins? 08/30/2018

Yes, besides AQP1, there are several other isoforms of aquaporin proteins. Some of the well-known isoforms include AQP2, AQP3, AQP4, AQP5, AQP7, and AQP9. Each isoform has a slightly different tissue distribution and function, allowing them to play unique roles in water and solute transport in various organs and tissues.

Can AQP1 be used as a biomarker for certain diseases? 05/06/2018

AQP1 expression or dysregulation has been observed in various diseases, making it a potential biomarker. For example, increased AQP1 expression has been associated with certain types of cancer, including lung, breast, and pancreatic cancers. Additionally, altered expression of AQP1 has been observed in conditions like glaucoma, brain edema, and kidney disorders.

Does AQP1 play a role in the transport of water during pregnancy? 02/25/2018

Yes, AQP1 is involved in the transport of water across the placenta during pregnancy. It is expressed in the maternal and fetal vascular endothelial cells of the placenta, facilitating the movement of water and solutes between the mother and fetus.

Does AQP1 have any role in the gastrointestinal system? 12/27/2017

AQP1 is not extensively expressed in the gastrointestinal system. However, it has been detected in specific regions, such as the gastric parietal cells and the secretory cells of the salivary glands. In these locations, AQP1 is involved in the regulation of fluid secretion and saliva production.

Is AQP1 involved in the transport of gases? 12/08/2017

No, AQP1 is not involved in the direct transport of gases such as oxygen (O2) and carbon dioxide (CO2). Its main function is to facilitate the movement of water molecules across cell membranes. However, the presence of AQP1 in certain tissues, such as the lungs and the red blood cells, indirectly contributes to the exchange and regulation of gases by maintaining the proper hydration and function of these tissues.

Can AQP1 modulate the permeability of small solutes? 04/18/2016

While AQP1 primarily facilitates the movement of water molecules across cell membranes, it has been shown to have some limited permeability to small solutes, such as glycerol and urea. However, its transport of solutes is far less efficient compared to its water transport capabilities.

How is AQP1 transported to the cell membrane? 04/18/2016

AQP1 is synthesized in the endoplasmic reticulum (ER) and then transported to the cell membrane through a vesicular trafficking system. It undergoes various protein-protein interactions and interactions with chaperones to ensure its proper folding and transport to the target location.

Can AQP1 be phosphorylated? 01/29/2016

Yes, AQP1 can be phosphorylated by different protein kinases, including protein kinase A (PKA) and protein kinase C (PKC). Phosphorylation of AQP1 can modulate its activity, cellular localization, and interaction with other proteins.

Customer Reviews (4)

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Reviews
11/22/2022

    the manufacturer's technical expertise can be advantageous to researchers.

    01/10/2022

      They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

      11/21/2019

        This technical support is invaluable, especially for researchers who may be new to working with AQP1 protein or if they encounter specific difficulties while conducting their experiments.

        11/24/2017

          This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

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