Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human AQP1 Protein, His-SUMO-tagged

Cat.No. : AQP1-1130H
Product Overview : Recombinant Human AQP1 Protein (220-269aa) was expressed in E. coli with N-terminal His-SUMO tag.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol.
Molecular Mass : 21.6 kDa
AA Sequence : GALAVLIYDFILAPRSSDLTDRVKV WTSGQVEEYDLDADDINSRVEMKPK
Purity : Greater than 90% as determined by SDS-PAGE.
Storage : The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Gene Name : AQP1 aquaporin 1 (Colton blood group) [ Homo sapiens ]
Official Symbol : AQP1
Synonyms : AQP1; aquaporin 1 (Colton blood group); aquaporin 1 (channel forming integral protein, 28kDa) , aquaporin 1 (channel forming integral protein, 28kDa, CO blood group) , CO, Colton blood group; aquaporin-1; CHIP28; aquaporin-CHIP; Colton blood group; urine water channel; channel-like integral membrane protein, 28-kDa; water channel protein for red blood cells and kidney proximal tubule; aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group); CO; AQP-CHIP; MGC26324
Gene ID : 358
mRNA Refseq : NM_001185060
Protein Refseq : NP_001171989
MIM : 107776
UniProt ID : P29972

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (29)

Ask a question
Are there any diseases associated with AQP1 dysfunction? 09/10/2022

Yes, AQP1 dysfunction has been associated with various diseases and conditions. For example, mutations in the AQP1 gene have been linked to hereditary recessive foveal hypoplasia, which is characterized by impaired water transport in the retina. Additionally, AQP1 has been implicated in the development and progression of conditions like acute respiratory distress syndrome (ARDS), cerebral edema, and kidney disorders.

Are there any drugs or inhibitors targeting AQP1? 08/28/2022

Currently, there are no FDA-approved drugs or specific inhibitors targeting AQP1. However, there is ongoing research towards the development of AQP1 modulators and blockers that could potentially be used for therapeutic purposes.

Can AQP1 play a role in cancer progression? 07/05/2022

Yes, AQP1 has been implicated in cancer progression and metastasis in certain types of cancer. It has been shown to be upregulated in various cancer cells, including colorectal, lung, and breast cancer cells. AQP1 has been suggested to promote tumor angiogenesis, invasion, and migration by facilitating water and ion transport across cell membranes. However, the exact mechanisms by which AQP1 contributes to cancer progression are still being studied.

Does AQP1 have any physiological roles other than water transport? 06/23/2022

Yes, apart from its role in water transport, AQP1 has been implicated in other physiological processes. For example, it has been suggested to play a role in cell migration and angiogenesis, as well as in the regulation of endothelial cell function and blood vessel permeability.

Can genetic mutations in the AQP1 gene cause any specific diseases? 04/26/2022

Yes, mutations in the AQP1 gene can lead to various diseases or conditions. One example is the deficiency of AQP1 in red blood cells, which can result in hereditary stomatocytosis, a rare condition characterized by abnormal red blood cell shape and reduced cell flexibility. Other AQP1 mutations have been associated with hydrocephalus, a condition characterized by the accumulation of cerebrospinal fluid in the brain.

Can AQP1 be found in the respiratory system? 02/06/2022

Yes, AQP1 is expressed in the respiratory system, specifically in the alveolar cells of the lungs. It helps in the transport of water across the alveolar epithelium, contributing to the proper humidification of inhaled air and the maintenance of lung function.

Can AQP1 be targeted for therapeutic purposes? 12/08/2021

The role of AQP1 in various diseases has sparked interest in targeting the protein for therapeutic purposes. Modulating AQP1 expression or activity may hold promise for treating conditions involving fluid imbalances, such as renal disorders, edema, and certain cancers. However, further research is needed to develop specific pharmacological approaches targeting AQP1.

Is AQP1 regulated by any factors? 11/18/2021

Yes, AQP1 expression and activity can be regulated by various factors. For example, water deprivation, osmotic gradients, hormone signaling, and changes in intracellular calcium levels can all influence AQP1 expression and cellular localization, thereby modulating its water transport capacity.

Are there any factors that can downregulate the expression or activity of AQP1? 09/12/2021

Several factors can downregulate the expression or activity of AQP1. For instance, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) can decrease AQP1 expression in various tissues. Additionally, certain drugs or chemical agents, such as mercury and cadmium, have been shown to inhibit AQP1 activity.

Are there any known AQP1 polymorphisms associated with diseases? 08/28/2021

Yes, certain polymorphisms or variations in the AQP1 gene have been identified and associated with specific diseases or conditions. For example, a single nucleotide polymorphism (SNP) known as AQP1-732C > T has been linked to increased risk of primary open-angle glaucoma. Other AQP1 polymorphisms have been studied in relation to conditions like diabetic retinopathy and essential hypertension, although more research is still needed to establish clear associations.

Is AQP1 involved in the regulation of fluid balance in the body? 08/08/2021

Yes, AQP1 plays a crucial role in the regulation of fluid balance in the body. It is involved in the reabsorption of water from various body fluids, including urine in the kidneys and respiratory secretions in the lungs. By facilitating water transport across cell membranes, AQP1 helps maintain proper hydration levels and fluid homeostasis.

Is AQP1 involved in the maintenance of fluid balance in the eye? 05/13/2021

Yes, AQP1 plays a vital role in maintaining fluid balance in the eye. It is expressed in the ciliary body and epithelium of the lens, where it facilitates the movement of water, ions, and nutrients, helping to maintain proper intraocular pressure and transparency of the lens.

Are there any known inhibitors or activators of AQP1? 03/14/2021

Several inhibitors of AQP1 have been identified and tested in preclinical studies. These include small molecule inhibitors like mercury-based compounds (such as HgCl2) and arylsulfonamide derivatives. These inhibitors can block the water transport activity of AQP1 and have been explored for their potential therapeutic use, particularly in cancer. However, further studies are needed to determine their efficacy and safety in clinical settings. There are currently no known activators of AQP1, as its activity is mainly regulated by other factors like hormonal and cellular signaling pathways.

Is AQP1 involved in the regulation of cell volume? 01/10/2021

Yes, AQP1 plays a role in the regulation of cell volume. By facilitating the movement of water across cell membranes, AQP1 helps maintain cell hydration and prevents excessive swelling or shrinkage of cells in response to changes in osmolarity or osmotic stress.

Does AQP1 have any role in the central nervous system? 11/10/2020

Yes, AQP1 has been detected in certain regions of the central nervous system (CNS), including the choroid plexus and ependymal cells. It is involved in the regulation of cerebrospinal fluid (CSF) formation and circulation. AQP1 allows for the movement of water across the blood-brain barrier, aiding in the exchange of water and solutes between the blood and the CNS.

Can AQP1 be targeted for therapeutic purposes? 01/25/2020

The role of AQP1 in various diseases and its involvement in water transport make it an attractive target for therapeutic purposes. Several research studies have explored the use of AQP1 inhibitors, antibodies, or gene therapy approaches to modulate its function and potentially treat conditions such as cancer, brain edema, and certain kidney disorders. However, further studies are needed to determine the efficacy and safety of such therapeutic approaches.

Can AQP1 transport substances other than water? 08/19/2019

While AQP1 primarily transports water, it can also facilitate the movement of small solutes such as urea, glycerol, and certain gases (e.g., carbon dioxide and nitric oxide). These molecules can pass through the narrow pore of AQP1 by a process called "paracellular permeability."

Are there any known diseases associated with AQP1 dysfunction? 05/16/2019

Yes, mutations or alterations in AQP1 have been implicated in several diseases. For instance, mutations in the AQP1 gene can lead to abnormalities in urinary concentration and renal function, resulting in conditions like nephrogenic diabetes insipidus. AQP1 dysregulation has also been implicated in diseases such as lung edema, brain edema, and certain types of cancer.

Are there any known interacting partners or regulators of AQP1? 12/06/2018

AQP1 can interact with other proteins or molecules to modulate its function. For example, AQP1 has been reported to interact with caveolin-1, an integral component of caveolae, to regulate its cellular localization and trafficking. Additionally, phosphorylation events mediated by protein kinases can modulate AQP1 activity and cellular responses in various tissues.

Are there any therapeutic implications of targeting AQP1? 09/14/2018

Yes, targeting AQP1 has shown potential therapeutic implications in various diseases. For instance, in cancer, inhibiting AQP1 has been explored as a strategy to inhibit tumor angiogenesis and metastasis. In kidney disorders, modulating AQP1 expression or activity may help regulate fluid balance and alleviate symptoms associated with disorders like polycystic kidney disease or nephrogenic diabetes insipidus. Additionally, targeting AQP1 in conditions like cerebral edema and acute respiratory distress syndrome (ARDS) may help reduce fluid accumulation and improve patient outcomes.

Can AQP1 expression be regulated by hormones? 09/03/2018

Yes, AQP1 expression can be regulated by hormones. For instance, in the kidney, the antidiuretic hormone vasopressin (ADH) can stimulate the translocation and insertion of AQP1 into the cell membrane, increasing water reabsorption. Similarly, hormonal regulation of AQP1 expression has been observed in other tissues, such as the respiratory epithelium.

Are there any other isoforms of aquaporin proteins? 08/30/2018

Yes, besides AQP1, there are several other isoforms of aquaporin proteins. Some of the well-known isoforms include AQP2, AQP3, AQP4, AQP5, AQP7, and AQP9. Each isoform has a slightly different tissue distribution and function, allowing them to play unique roles in water and solute transport in various organs and tissues.

Can AQP1 be used as a biomarker for certain diseases? 05/06/2018

AQP1 expression or dysregulation has been observed in various diseases, making it a potential biomarker. For example, increased AQP1 expression has been associated with certain types of cancer, including lung, breast, and pancreatic cancers. Additionally, altered expression of AQP1 has been observed in conditions like glaucoma, brain edema, and kidney disorders.

Does AQP1 play a role in the transport of water during pregnancy? 02/25/2018

Yes, AQP1 is involved in the transport of water across the placenta during pregnancy. It is expressed in the maternal and fetal vascular endothelial cells of the placenta, facilitating the movement of water and solutes between the mother and fetus.

Does AQP1 have any role in the gastrointestinal system? 12/27/2017

AQP1 is not extensively expressed in the gastrointestinal system. However, it has been detected in specific regions, such as the gastric parietal cells and the secretory cells of the salivary glands. In these locations, AQP1 is involved in the regulation of fluid secretion and saliva production.

Is AQP1 involved in the transport of gases? 12/08/2017

No, AQP1 is not involved in the direct transport of gases such as oxygen (O2) and carbon dioxide (CO2). Its main function is to facilitate the movement of water molecules across cell membranes. However, the presence of AQP1 in certain tissues, such as the lungs and the red blood cells, indirectly contributes to the exchange and regulation of gases by maintaining the proper hydration and function of these tissues.

Can AQP1 modulate the permeability of small solutes? 04/18/2016

While AQP1 primarily facilitates the movement of water molecules across cell membranes, it has been shown to have some limited permeability to small solutes, such as glycerol and urea. However, its transport of solutes is far less efficient compared to its water transport capabilities.

How is AQP1 transported to the cell membrane? 04/18/2016

AQP1 is synthesized in the endoplasmic reticulum (ER) and then transported to the cell membrane through a vesicular trafficking system. It undergoes various protein-protein interactions and interactions with chaperones to ensure its proper folding and transport to the target location.

Can AQP1 be phosphorylated? 01/29/2016

Yes, AQP1 can be phosphorylated by different protein kinases, including protein kinase A (PKA) and protein kinase C (PKC). Phosphorylation of AQP1 can modulate its activity, cellular localization, and interaction with other proteins.

Customer Reviews (4)

Write a review
Reviews
11/22/2022

    the manufacturer's technical expertise can be advantageous to researchers.

    01/10/2022

      They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

      11/21/2019

        This technical support is invaluable, especially for researchers who may be new to working with AQP1 protein or if they encounter specific difficulties while conducting their experiments.

        11/24/2017

          This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

          Ask a Question for All AQP1 Products

          Required fields are marked with *

          My Review for All AQP1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends