AQP4
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Official Full Name
aquaporin 4
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Overview
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
AQP4; aquaporin 4; aquaporin-4; MIWC; WCH4; aquaporin type4; mercurial-insensitive water channel; HMIWC2; MGC22454;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Dipodomys merriami (Merriam's kangaroo rat)
- Human
- Milnesium tardigradum (Water bear) (Tardigrade)
- Mouse
- Mus musculus (Mouse)
- Notomys alexis (Spinifex hopping mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- GFP
- GST
- His
- His (Fc)
- Avi
- Myc
- His|GST
- His|SUMO
- N/A
- N
- Tag
- Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AQP4-9782H | Recombinant Human AQP4, GST-tagged | E.coli | GST | 208-323a.a. | |
Human | AQP4-1131H | Recombinant Human AQP4 Protein, His-SUMO-tagged | E.coli | His/SUMO | ||
Human | AQP4-9731H | Recombinant Human AQP4 protein, His-tagged | Yeast | His | 253-323aa | |
Human | AQP4-9735H | Recombinant Human AQP4 protein, His-GST-tagged | E.coli | His/GST | Cys178~Gly317 | |
Human | AQP4-734H | Recombinant Human AQP4 protein, GST-tagged | Wheat Germ | GST | ||
Human | AQP4-32HCL | Recombinant Human AQP4 lysate | HEK293 | N/A | ||
Human | AQP4-3447H | Recombinant Human AQP4 protein, His-tagged | E.coli | His | 208-323 aa | |
Human | AQP4-0295H | Recombinant Human AQP4 Protein (Thr208-Val323), N-His-tagged | E.coli | N-His | Thr208-Val323 | |
Human | AQP4-1157HF | Recombinant Full Length Human AQP4 Protein, GST-tagged | In Vitro Cell Free System | GST | 323 amino acids | |
Human | AQP4-0294H | Recombinant Human AQP4 Protein (Met23-Val323), C-GFP-tagged | Mammalian cells | C-GFP | Met23-Val323 | |
Mouse | AQP4-3594M | Recombinant Mouse Aqp4 protein, His-tagged | E.coli | His | Ser177~Ile304 | |
Mouse | Aqp4-3600M | Recombinant Mouse Aqp4, His-tagged | E.Coli or Yeast | His | 70 | |
Mouse | Aqp4-1049M | Recombinant Mouse Aqp4 Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 1-323aa | |
Mouse | Aqp4-1048M | Recombinant Mouse Aqp4 Full Length Transmembrane protein | In vitro E. coli expression system | N/A | 1-323aa | |
Mouse | Aqp4-5345M | Recombinant Mouse Aqp4 protein, His-Myc-tagged | Yeast | His/Myc | 253-323aa | |
Mouse | AQP4-2226M | Recombinant Mouse AQP4 Protein (253-323 aa), His-tagged | Yeast | His | 253-323 aa | |
Rat | Aqp4-2602R | Recombinant Rat Aqp4 protein, His & GST-tagged | E.coli | His/GST | Asp179~Asp314 | |
Rat | AQP4-738R | Recombinant Rat AQP4 Protein | Mammalian Cell | His | ||
Rat | Aqp4-3532R | Recombinant Rat Aqp4 protein, His-tagged | E.coli | His | Asp179~Asp314 | |
Rat | AQP4-394R | Recombinant Rat AQP4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AQP4-394R-B | Recombinant Rat AQP4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bos taurus (Bovine) | RFL-28054BF | Recombinant Full Length Bovine Aquaporin-4(Aqp4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-323) | |
Dipodomys merriami (Merriam's kangaroo rat) | RFL30404DF | Recombinant Full Length Dipodomys Merriami Aquaporin-4(Aqp4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-324) | |
Milnesium tardigradum (Water bear) (Tardigrade) | RFL28298MF | Recombinant Full Length Milnesium Tardigradum Aquaporin-4(Aqp4) Protein, Tag-Free | E.coli expression system | Tag-Free | Full Length (1-349) | |
Mus musculus (Mouse) | RFL-2327MF | Recombinant Full Length Mouse Aquaporin-4(Aqp4) Protein, Tag-Free | E.coli expression system | Tag-Free | Full Length (1-323aa) | |
Notomys alexis (Spinifex hopping mouse) | RFL5552NF | Recombinant Full Length Notomys Alexis Aquaporin-4(Aqp4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Rattus norvegicus (Rat) | RFL-21119RF | Recombinant Full Length Rat Aquaporin-4(Aqp4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-323) | |
Rhesus Macaque | AQP4-374R | Recombinant Rhesus monkey AQP4 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | AQP4-203R | Recombinant Rhesus Macaque AQP4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | AQP4-203R-B | Recombinant Rhesus Macaque AQP4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | AQP4-1088Z | Recombinant Zebrafish AQP4 | Mammalian Cell | His | ||
Chicken | AQP4-1236C | Recombinant Chicken AQP4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- AQP4 Related Articles
AQP4 involved in several pathways and played different roles in them. We selected most pathways AQP4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Bile secretion | Car2;SCARB1;AQP9;AQP1;SLC22A8;RXRA;SLCO1B3;ATP1B1;SLCO1B2 |
AQP4 has several biochemical functions, for example, glycerol channel activity, water channel activity, water transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP4 itself. We selected most functions AQP4 had, and list some proteins which have the same functions with AQP4. You can find most of the proteins on our site.
Function | Related Protein |
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glycerol channel activity | AQP2;AQP8A.1;MIPA;AQP8;AQP1A.2;AQP10;AQP3;AQP4;AQP10A |
water channel activity | AQP8;MIPA;AQP9;AQP6;AQP3;MIP;AQP2;AQP8A.1;AQP10 |
water transmembrane transporter activity | AQP10B;AQP9A;AQP9B;AQP8A.2;MIPB;AQP3B;AQP10A;SLC14A1;AQP3A |
AQP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP4.
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- Q&As
- Reviews
Q&As (20)
Ask a questionCurrently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.
Currently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.
Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.
Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.
In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.
In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.
AQP4 is found in the astrocytes surrounding blood vessels in the retina. It helps in the reabsorption of excess water from the retina, contributing to the maintenance of clear vision and the prevention of edema in the eye.
Yes, AQP4 is expressed in other organs as well. It is found in the kidneys, lungs, gastrointestinal tract, salivary glands, and other tissues where water transport is essential for their proper functioning.
Currently, there is no cure for NMOSD, but treatments aim to manage symptoms and prevent relapses. These may include immunosuppressive drugs, plasma exchange, and other supportive therapies.
AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.
AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.
Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.
Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.
Dysfunction or dysregulation of AQP4 can lead to brain edema, which is the accumulation of excess fluid in the brain tissue. Reduced AQP4 expression or altered localization may interfere with the clearance of water from brain cells, resulting in swelling and increased intracranial pressure.
AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.
AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.
Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.
Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.
Yes, AQP4 dysfunction has been strongly linked to neuromyelitis optica spectrum disorder (NMOSD), an autoimmune disease that primarily affects the optic nerves and spinal cord. Autoantibodies target AQP4, leading to inflammation and damage in these areas.
While its primary role is water transportation, studies suggest that AQP4 may play additional roles in cellular processes such as cell migration, neuroinflammation, and neuroprotection. However, further research is needed to fully understand these functions.
Customer Reviews (8)
Write a reviewIn addition to these experimental benefits, the manufacturer of Aqp4 protein plays a vital role in supporting researchers.
Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.
This partnership enhances research productivity while ensuring accurate and meaningful outcomes.
Aqp4 protein demonstrates exceptional stability and consistency, ensuring reliable and reproducible results throughout the duration of the trial.
Aqp4 protein exhibits high bioactivity, enabling efficient and effective interactions with its molecular targets.
The manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.
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