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Recombinant Mouse AQP4 Protein (253-323 aa), His-tagged

Cat.No. : AQP4-2226M
Product Overview : Recombinant Mouse AQP4 Protein (253-323 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.
  • Specification
  • Gene Information
  • Related Products
Description : Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Source : Yeast
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 9.9 kDa
Protein length : 253-323 aa
AA Sequence : CPDVELKRRLKEAFSKAAQQTKGSY MEVEDNRSQVETEDLILKPGVVHVI DIDRGEEKKGKDSSGEVLSSV
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Gene Name : Aqp4 aquaporin 4 [ Mus musculus ]
Official Symbol : AQP4
Synonyms : AQP4; aquaporin 4; aquaporin-4; AQP-4; mercurial-insensitive water channel; WCH4;
Gene ID : 11829
mRNA Refseq : NM_009700
Protein Refseq : NP_033830
UniProt ID : P55088

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Are there any drugs or compounds that specifically target AQP4? 09/12/2022

Currently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.

Are there any drugs or compounds that specifically target AQP4? 09/12/2022

Currently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.

Can AQP4 be used as a diagnostic marker for NMOSD? 10/26/2021

Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.

Can AQP4 be used as a diagnostic marker for NMOSD? 10/26/2021

Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.

How does AQP4 play a role in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD)? 10/10/2021

In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.

How does AQP4 play a role in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD)? 10/10/2021

In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.

How does the AQP4 protein contribute to vision? 05/09/2021

AQP4 is found in the astrocytes surrounding blood vessels in the retina. It helps in the reabsorption of excess water from the retina, contributing to the maintenance of clear vision and the prevention of edema in the eye.

Can the AQP4 protein be found in other organs besides the brain and eye? 12/01/2020

Yes, AQP4 is expressed in other organs as well. It is found in the kidneys, lungs, gastrointestinal tract, salivary glands, and other tissues where water transport is essential for their proper functioning.

Are there any treatments targeting AQP4-related diseases? 08/03/2019

Currently, there is no cure for NMOSD, but treatments aim to manage symptoms and prevent relapses. These may include immunosuppressive drugs, plasma exchange, and other supportive therapies.

Can AQP4 be targeted for potential therapeutic interventions? 01/25/2019

AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.

Can AQP4 be targeted for potential therapeutic interventions? 01/25/2019

AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.

Are there any known genetic variations or mutations in the AQP4 gene? 10/16/2018

Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.

Are there any known genetic variations or mutations in the AQP4 gene? 10/16/2018

Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.

How does AQP4 contribute to brain edema? 07/19/2017

Dysfunction or dysregulation of AQP4 can lead to brain edema, which is the accumulation of excess fluid in the brain tissue. Reduced AQP4 expression or altered localization may interfere with the clearance of water from brain cells, resulting in swelling and increased intracranial pressure.

What other diseases or conditions are associated with AQP4 dysfunction or dysregulation? 05/12/2017

AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.

What other diseases or conditions are associated with AQP4 dysfunction or dysregulation? 05/12/2017

AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.

Are there any ongoing clinical trials targeting AQP4? 04/09/2017

Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.

Are there any ongoing clinical trials targeting AQP4? 04/09/2017

Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.

Are there any diseases associated with AQP4 dysfunction? 03/11/2017

Yes, AQP4 dysfunction has been strongly linked to neuromyelitis optica spectrum disorder (NMOSD), an autoimmune disease that primarily affects the optic nerves and spinal cord. Autoantibodies target AQP4, leading to inflammation and damage in these areas.

Are there any other known functions or roles of AQP4? 05/21/2016

While its primary role is water transportation, studies suggest that AQP4 may play additional roles in cellular processes such as cell migration, neuroinflammation, and neuroprotection. However, further research is needed to fully understand these functions.

Customer Reviews (8)

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Reviews
03/05/2022

    In addition to these experimental benefits, the manufacturer of Aqp4 protein plays a vital role in supporting researchers.

    01/14/2022

      Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.

      10/20/2021

        the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.

        10/10/2021

          Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.

          05/12/2021

            This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

            12/06/2020

              Aqp4 protein demonstrates exceptional stability and consistency, ensuring reliable and reproducible results throughout the duration of the trial.

              09/21/2020

                Aqp4 protein exhibits high bioactivity, enabling efficient and effective interactions with its molecular targets.

                05/28/2017

                  The manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.

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