|Official Full Name||Rho guanine nucleotide exchange factor (GEF) 1|
|Background||Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that;work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate;Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the;full-length nature of some variants has not been defined.|
|Synonyms||ARHGEF1; Rho guanine nucleotide exchange factor (GEF) 1; rho guanine nucleotide exchange factor 1; LBCL2; P115 RHOGEF; SUB1.5; 115 kD protein; 115 kDa guanine nucleotide exchange factor; ARHGEF 1; GEF 1; GEF1; LBCL 2; Lsc homolog; p115RhoGEF; 115-kD protein; LSC; P115-RHOGEF|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ARHGEF1 involved in several pathways and played different roles in them. We selected most pathways ARHGEF1 participated on our site, such as Vascular smooth muscle contraction, Platelet activation, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Vascular smooth muscle contraction||RHOAD; MYL9B; PRKCHA; RAF1A; MAP2K2; PPP1CAB; CALML5; GUCY1B3; PLA2G4F; PPP1CC|
|Platelet activation||P2RY1; PRKACA; ARHGEF12; GUCY1A3; PIK3CG; SRC; MAPK1; MAPK3; PRKACB; ROCK1|
|Regulation of actin cytoskeleton||FGF6B; FGF3; PXN; MYH9; APC; ARHGEF1; ACTN4; MYL10; PIK3R3A; PFN3|
|Pathways in cancer||PLCB4; BDKRB1; TRAF4; GNG7; PRKCA; MDM2; STAT5A; GNG10; SMAD2; WNT16|
|Proteoglycans in cancer||TGFB1; CAMK2D; WNT10B; PIK3R5; NANOG; MMP9; PXN; DROSHA; HPSE2; PPP1CC|
ARHGEF1 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF1 itself. We selected most functions ARHGEF1 had, and list some proteins which have the same functions with ARHGEF1. You can find most of the proteins on our site.
|GTPase activator activity||RGS20; GRTP1A; PGAM5; GIT2; PREX2; RGS11; RABEP2; RASGRP3; RIN3; RGS18|
|Rho guanyl-nucleotide exchange factor activity||DCLRE1B; SOS1; AKAP13; ARHGEF9; PLEKHG7; PLEKHG4; ARHGEF2; FGD; ARHGEF1; ARHGEF12|
|poly(A) RNA binding||DDX52; MYO5A; FASTKD1; RP9; SF3A2; RBM4B; PDCD11; DYNC1H1; DDX17; DAP3|
|protein binding||BIRC3; ZNF664-FAM101A; ILKAP; ITGAM; ZNF69; UBE2V2; MCL1; ADAMTS13; HIST1H4J; IGF2|
ARHGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF1.
q7db74_eco57; TCF4; GNA13; q81y32_bacan; CSNK1E; RHOB; SREBF2; mhpD1; iolA2; pi3p