arhgef2
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  • Official Full Name
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2
  • Background
  • Rho family small GTPases regulate processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. GEF-H1 is a Rho GEF that localiz
  • Synonyms
  • ARHGEF2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; rho guanine nucleotide exchange factor 2; GEF H1; KIAA0651; LFP40; P40; microtubule-regulated Rho-GEF; guanine nucleotide exchange factor H1
Cat.#:ARHGEF2-785HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARHGEF2 protein, GST-tagged
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Cat.#:ARHGEF2-770RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ARHGEF2 Protein
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Cat.#:ARHGEF2-8732HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ARHGEF2 293 Cell Lysate
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Involved Pathway

ARHGEF2 involved in several pathways and played different roles in them. We selected most pathways ARHGEF2 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathogenic Escherichia coli infection
TUBB6; TUBA1A; WAS; LY96; CTTN; TUBB1; YWHAZ; ROCK1; ACTG1; ABL1

Protein Function

ARHGEF2 has several biochemical functions, for example, Rac GTPase binding, Rac guanyl-nucleotide exchange factor activity, Rho GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF2 itself. We selected most functions ARHGEF2 had, and list some proteins which have the same functions with ARHGEF2. You can find most of the proteins on our site.
Function
Related Protein
Function Rac GTPase binding
Related Protein SRGAP2A; ARHGEF2; SOD1; EPS8; ARHGAP4; PAK4; SRGAP3; RALBP1; DOCK7; PKN1
Function Rac guanyl-nucleotide exchange factor activity
Related Protein VAV1; PREX2; ALS2; ARHGEF4; ARHGEF2; FARP1; FARP2; SPATA13; DOCK2; VAV3
Function Rho GTPase binding
Related Protein DOCK9; DIAPH1; PFN1; FMNL2; DIAPH3; DAPK3; DIAP3; ARHGEF16; ARHGEF2; CDC42BPB
Function Rho guanyl-nucleotide exchange factor activity
Related Protein FGD2; PLEKHG3; ECT2; ARHGEF1B; SOS1; ARHGEF11; ARHGEF16; ARHGEF39; FGD; FGD4A
Function microtubule binding
Related Protein WHAMM; RCC2; GOLSYN; HOOK3; KIF4A; CRIPT; CLIP3; CEP57L1; PEX14; KIF13B
Function protein binding
Related Protein GDF5; TCEB1; NIPSNAP1; SFRS9; UBE2D1; CDKN2A; PTPN22; ASCC3; BIRC5; POLR2A
Function transcription factor binding
Related Protein KCTD1; HMGB1; PIAS2; DIP2B; PSMC5; MYOD1; NR0B2A; GATA6; FIGLA; DDX3X
Function zinc ion binding
Related Protein RUFY1; ANKIB1; TRIM10; RNF123; DNAJC24; GDA; LIMCH1A; RNF151; USP3; ZFP37

Interacting Protein

ARHGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF2.
YWHAG; MYC; YWHAZ; RPP25L; ANKRD28; NFKBIE; PAK4; MARK2; KSR1; q81ql4_bacan; pi3p; 15-deoxy-delta(12,14; ssrna_ug

ARHGEF2 Related Articles

Zheng, ZL; Liebers, M; et al. Anchored multiplex FOR for targeted next-generation sequencing. NATURE MEDICINE 20:1479-1484(2014).
Huang, IH; Hsiao, CT; et al. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. JOURNAL OF CELL SCIENCE 127:4186-4200(2014).