ARHGEF2
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Official Full Name
Rho/Rac guanine nucleotide exchange factor (GEF) 2
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Overview
Rho family small GTPases regulate processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. GEF-H1 is a Rho GEF that localiz -
Synonyms
ARHGEF2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; rho guanine nucleotide exchange factor 2; GEF H1; KIAA0651; LFP40; P40; microtubule-regulated Rho-GEF; guanine nucleotide exchange factor H1;
- Recombinant Proteins
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- Wheat Germ
- C
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- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGEF2 Related Articles
ARHGEF2 involved in several pathways and played different roles in them. We selected most pathways ARHGEF2 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pathogenic Escherichia coli infection | NCK2;TUBA1C;CTTN;CLDN1;YWHAZ;NCL;PRKCA;CDH1;ACTB |
ARHGEF2 has several biochemical functions, for example, Rac GTPase binding, Rac guanyl-nucleotide exchange factor activity, Rho GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF2 itself. We selected most functions ARHGEF2 had, and list some proteins which have the same functions with ARHGEF2. You can find most of the proteins on our site.
Function | Related Protein |
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Rac GTPase binding | PKN1;CORO1C;ARHGAP4A;SRGAP3;SRGAP2;DOCK7;PAK2;PAK6;SOD1 |
Rac guanyl-nucleotide exchange factor activity | ARHGEF4;VAV1;FARP2;DOCK2;SPATA13;PREX2;ARHGEF2;VAV3;FARP1 |
Rho GTPase binding | ARHGEF16;DIAPH3;FMNL2;KIF3B;CDC42BPB;CSDA;DAAM1B;PARD6A;ANTXR2A |
Rho guanyl-nucleotide exchange factor activity | ARHGEF25;PLEKHG7;FGD4A;ARHGEF33;RASGRF2B;NET1;ARHGEF17;PLEKHG5;ITSN2 |
microtubule binding | KIF15;DPYSL5;POLB;MAPT;GAPDH;SPAG8;KIF3B;CRYAB;KIF12 |
protein binding | NRG4;ZNF34;UBAP2L;STAT4;MYOG;CC10;KCNG3;RIBC2;PIGK |
transcription factor binding | FHL2;TRERF1;TNFRSF10A;ATF7;PPID;HOXA7;IFT172;HES3;ARHGEF2 |
zinc ion binding | MT1M;NR1D4B;BTR16;NR6A1B;MTF2;CA4;ADAM9;ADAM15;LNX2A |
ARHGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF2.
YWHAG; MYC; YWHAZ; RPP25L; ANKRD28; NFKBIE; PAK4; MARK2; KSR1; q81ql4_bacan; pi3p; 15-deoxy-delta(12,14; ssrna_ug
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Q&As (8)
Ask a questionTargeting ARHGEF2 or its downstream effectors could hold therapeutic potential for various diseases. Given its role in cancer metastasis, inhibiting ARHGEF2 could help prevent or reduce tumor cell invasion and migration. Modulating ARHGEF2 activity could also be beneficial in cardiovascular diseases by regulating blood vessel contraction and cardiac hypertrophy. Furthermore, targeting ARHGEF2 in neurological disorders might help regulate neuronal development and synaptic plasticity.
ARHGEF2 can interact with multiple proteins to exert its functions. It has been reported to interact with and activate several Rho GTPases, including RhoA, RhoB, and RhoC. ARHGEF2 can also interact with other signaling molecules, such as focal adhesion kinase (FAK), paxillin, and Galpha12/13 proteins, to regulate cytoskeletal dynamics and cell adhesion.
Yes, ARHGEF2 can interact with several other proteins involved in cell signaling pathways. It can interact with integrin-associated proteins like vinculin and talin, as well as adherens junction proteins such as E-cadherin, β-catenin, and α-catenin. These interactions modulate cell adhesion and cytoskeletal dynamics. Additionally, ARHGEF2 can interact with signaling molecules like G-protein-coupled receptors (GPCRs), growth factor receptors, and non-receptor tyrosine kinases, enabling crosstalk between different signaling pathways.
ARHGEF2 has been shown to activate RhoA, which in turn regulates a variety of downstream effectors and signaling pathways. This includes the Rho-associated protein kinase (ROCK) pathway, which controls actin-myosin contractility and cell shape changes, as well as the mDia and IRSp53 pathways involved in actin filament assembly. Additionally, ARHGEF2 can activate Rac1, which can activate JNK and p38 MAP kinase pathways to influence cell migration and invasion.
Yes, mutations in the ARHGEF2 gene have been associated with different disorders. In particular, loss-of-function mutations in ARHGEF2 have been linked to intellectual disability and developmental delay. These mutations can lead to altered Rho GTPase signaling, affecting cellular processes involved in neural development and cognition. Additionally, variations in the ARHGEF2 gene have been found to be associated with hypertension susceptibility in certain populations.
Yes, research on ARHGEF2 is ongoing. Scientists continue to investigate its role in various cellular processes and its involvement in different diseases. They are studying the mechanisms of ARHGEF2 activation, its interaction partners, and the downstream pathways it regulates. Additionally, efforts are being made to explore potential therapeutic strategies targeting ARHGEF2 for diseases such as cancer and neurological disorders.
ARHGEF2 is involved in multiple cellular processes, including actin cytoskeleton organization, cell adhesion, cell migration, cell proliferation, and cell polarity. It regulates these processes by activating Rho GTPases, which in turn control the organization of the actin cytoskeleton and the dynamics of cell shape changes. ARHGEF2 is essential for various physiological processes, such as development, tissue homeostasis, and wound healing, and its dysregulation is associated with pathological conditions like cancer and cardiovascular diseases.
Yes, ARHGEF2 has been implicated in various diseases and pathological conditions. It has been found to be involved in cancer progression and metastasis by promoting cell migration, invasion, and epithelial-mesenchymal transition (EMT). ARHGEF2 has also been linked to cardiovascular diseases, such as hypertension and cardiac hypertrophy, as well as neuronal disorders, including epilepsy and intellectual disability.
Customer Reviews (8)
Write a reviewthe manufacturer's commitment to delivering the ARHGEF2 protein in a timely manner is greatly appreciated.
the ARHGEF2 protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.
Their prompt and knowledgeable assistance has the potential to solve any difficulties I may encounter during my experiments.
The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.
The cost-effectiveness of the ARHGEF2 protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.
Another advantage of the ARHGEF2 protein is its reliability and consistency, ensuring robust and reproducible results.
the manufacturer's support plays a crucial role in the successful implementation of trials involving the ARHGEF2 protein.
I am confident that my experimental needs will be met through their assistance, ensuring successful outcomes in my trials.
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