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ARHGEF2

  • Official Full Name

    Rho/Rac guanine nucleotide exchange factor (GEF) 2

  • Overview

    Rho family small GTPases regulate processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. GEF-H1 is a Rho GEF that localiz
  • Synonyms

    ARHGEF2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; rho guanine nucleotide exchange factor 2; GEF H1; KIAA0651; LFP40; P40; microtubule-regulated Rho-GEF; guanine nucleotide exchange factor H1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF2-785H Recombinant Human ARHGEF2 protein, GST-tagged Wheat Germ GST
Human ARHGEF2-8732HCL Recombinant Human ARHGEF2 293 Cell Lysate HEK293 N/A
Human ARHGEF2-03H Recombinant Human ARHGEF2 Protein, N-GST-tagged Wheat Germ N-GST 860-959 aa
Human ARHGEF2-1682H Recombinant Human ARHGEF2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARHGEF2-12HFL Recombinant Full Length Human ARHGEF2 Protein, C-Flag-tagged HEK293T C-Flag Full Length
Human ARHGEF2-1103HF Recombinant Full Length Human ARHGEF2 Protein, GST-tagged In Vitro Cell Free System GST 959 amino acids
Human ARHGEF2-04H Recombinant Human ARHGEF2 Protein, N-GST-tagged Wheat Germ N-GST 590-690 aa
Mouse Arhgef2-1297M Recombinant Mouse Arhgef2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ARHGEF2-05M Recombinant Mouse ARHGEF2 Protein, C-Flag-tagged HEK293 C-Flag
Rat ARHGEF2-770R Recombinant Rat ARHGEF2 Protein Mammalian Cell His
Rat ARHGEF2-426R Recombinant Rat ARHGEF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARHGEF2-426R-B Recombinant Rat ARHGEF2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGEF2 Related Articles

ARHGEF2 involved in several pathways and played different roles in them. We selected most pathways ARHGEF2 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathogenic Escherichia coli infectionNCK2;TUBA1C;CTTN;CLDN1;YWHAZ;NCL;PRKCA;CDH1;ACTB

ARHGEF2 has several biochemical functions, for example, Rac GTPase binding, Rac guanyl-nucleotide exchange factor activity, Rho GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF2 itself. We selected most functions ARHGEF2 had, and list some proteins which have the same functions with ARHGEF2. You can find most of the proteins on our site.

Function Related Protein
Rac GTPase bindingPKN1;CORO1C;ARHGAP4A;SRGAP3;SRGAP2;DOCK7;PAK2;PAK6;SOD1
Rac guanyl-nucleotide exchange factor activityARHGEF4;VAV1;FARP2;DOCK2;SPATA13;PREX2;ARHGEF2;VAV3;FARP1
Rho GTPase bindingARHGEF16;DIAPH3;FMNL2;KIF3B;CDC42BPB;CSDA;DAAM1B;PARD6A;ANTXR2A
Rho guanyl-nucleotide exchange factor activityARHGEF25;PLEKHG7;FGD4A;ARHGEF33;RASGRF2B;NET1;ARHGEF17;PLEKHG5;ITSN2
microtubule bindingKIF15;DPYSL5;POLB;MAPT;GAPDH;SPAG8;KIF3B;CRYAB;KIF12
protein bindingNRG4;ZNF34;UBAP2L;STAT4;MYOG;CC10;KCNG3;RIBC2;PIGK
transcription factor bindingFHL2;TRERF1;TNFRSF10A;ATF7;PPID;HOXA7;IFT172;HES3;ARHGEF2
zinc ion bindingMT1M;NR1D4B;BTR16;NR6A1B;MTF2;CA4;ADAM9;ADAM15;LNX2A

ARHGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF2.

YWHAG; MYC; YWHAZ; RPP25L; ANKRD28; NFKBIE; PAK4; MARK2; KSR1; q81ql4_bacan; pi3p; 15-deoxy-delta(12,14; ssrna_ug

Zheng, ZL; Liebers, M; et al. Anchored multiplex FOR for targeted next-generation sequencing. NATURE MEDICINE 20:1479-1484(2014).
Huang, IH; Hsiao, CT; et al. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. JOURNAL OF CELL SCIENCE 127:4186-4200(2014).
  • Q&As
  • Reviews

Q&As (8)

Ask a question
What are the potential therapeutic implications of targeting ARHGEF2? 02/18/2023

Targeting ARHGEF2 or its downstream effectors could hold therapeutic potential for various diseases. Given its role in cancer metastasis, inhibiting ARHGEF2 could help prevent or reduce tumor cell invasion and migration. Modulating ARHGEF2 activity could also be beneficial in cardiovascular diseases by regulating blood vessel contraction and cardiac hypertrophy. Furthermore, targeting ARHGEF2 in neurological disorders might help regulate neuronal development and synaptic plasticity.

Are there any known interacting partners of ARHGEF2? 01/22/2021

ARHGEF2 can interact with multiple proteins to exert its functions. It has been reported to interact with and activate several Rho GTPases, including RhoA, RhoB, and RhoC. ARHGEF2 can also interact with other signaling molecules, such as focal adhesion kinase (FAK), paxillin, and Galpha12/13 proteins, to regulate cytoskeletal dynamics and cell adhesion.

Can ARHGEF2 interact with other proteins involved in cell signaling pathways? 06/05/2020

Yes, ARHGEF2 can interact with several other proteins involved in cell signaling pathways. It can interact with integrin-associated proteins like vinculin and talin, as well as adherens junction proteins such as E-cadherin, β-catenin, and α-catenin. These interactions modulate cell adhesion and cytoskeletal dynamics. Additionally, ARHGEF2 can interact with signaling molecules like G-protein-coupled receptors (GPCRs), growth factor receptors, and non-receptor tyrosine kinases, enabling crosstalk between different signaling pathways.

What are the potential downstream effectors or signaling pathways regulated by ARHGEF2? 11/10/2018

ARHGEF2 has been shown to activate RhoA, which in turn regulates a variety of downstream effectors and signaling pathways. This includes the Rho-associated protein kinase (ROCK) pathway, which controls actin-myosin contractility and cell shape changes, as well as the mDia and IRSp53 pathways involved in actin filament assembly. Additionally, ARHGEF2 can activate Rac1, which can activate JNK and p38 MAP kinase pathways to influence cell migration and invasion.

Are there any known genetic mutations or polymorphisms in the ARHGEF2 gene? 06/11/2018

Yes, mutations in the ARHGEF2 gene have been associated with different disorders. In particular, loss-of-function mutations in ARHGEF2 have been linked to intellectual disability and developmental delay. These mutations can lead to altered Rho GTPase signaling, affecting cellular processes involved in neural development and cognition. Additionally, variations in the ARHGEF2 gene have been found to be associated with hypertension susceptibility in certain populations.

Are there any ongoing research efforts focused on ARHGEF2? 05/29/2018

Yes, research on ARHGEF2 is ongoing. Scientists continue to investigate its role in various cellular processes and its involvement in different diseases. They are studying the mechanisms of ARHGEF2 activation, its interaction partners, and the downstream pathways it regulates. Additionally, efforts are being made to explore potential therapeutic strategies targeting ARHGEF2 for diseases such as cancer and neurological disorders.

What are the cellular processes and functions associated with ARHGEF2? 01/24/2018

ARHGEF2 is involved in multiple cellular processes, including actin cytoskeleton organization, cell adhesion, cell migration, cell proliferation, and cell polarity. It regulates these processes by activating Rho GTPases, which in turn control the organization of the actin cytoskeleton and the dynamics of cell shape changes. ARHGEF2 is essential for various physiological processes, such as development, tissue homeostasis, and wound healing, and its dysregulation is associated with pathological conditions like cancer and cardiovascular diseases.

Is ARHGEF2 associated with any diseases or pathological conditions? 01/25/2017

Yes, ARHGEF2 has been implicated in various diseases and pathological conditions. It has been found to be involved in cancer progression and metastasis by promoting cell migration, invasion, and epithelial-mesenchymal transition (EMT). ARHGEF2 has also been linked to cardiovascular diseases, such as hypertension and cardiac hypertrophy, as well as neuronal disorders, including epilepsy and intellectual disability.

Customer Reviews (8)

Write a review
Reviews
10/09/2021

    the manufacturer's commitment to delivering the ARHGEF2 protein in a timely manner is greatly appreciated.

    05/02/2021

      the ARHGEF2 protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

      01/04/2021

        Their prompt and knowledgeable assistance has the potential to solve any difficulties I may encounter during my experiments.

        09/02/2020

          The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.

          10/25/2019

            The cost-effectiveness of the ARHGEF2 protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.

            01/15/2019

              Another advantage of the ARHGEF2 protein is its reliability and consistency, ensuring robust and reproducible results.

              11/29/2018

                the manufacturer's support plays a crucial role in the successful implementation of trials involving the ARHGEF2 protein.

                10/26/2016

                  I am confident that my experimental needs will be met through their assistance, ensuring successful outcomes in my trials.

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