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Recombinant Human ARHGEF2 protein, GST-tagged

Cat.No. : ARHGEF2-785H
Product Overview : Human ARHGEF2 full-length ORF ( AAH20567, 1 a.a. - 959 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 131.12 kDa
AA Sequence : MKEAKDARYTNGHLFTTISVSGMTM CYACNKSITAKEALICPTCNVTIHN RCKDTLANCTKVKQKQQKAALLKNN TALQSVSLRSKTTIRERPSSAIYPS DSFRQSLLGSRRGRSSLSLAKSVST TNIAGHFNDESPLGLRRILSQSTDS LNMRNRTLSVESLIDEAEVIYSELM SDFEMDEKDFAADSWSLAVDSSFLQ QHKKEVMKQQDVIYELIQTELHHVR TLKIMTRLFRTGMLEELHLEPGVVQ GLFPCVDELSDIHTRFLSQLLERRR QALCPGSTRNFVIHRLGDLLISQFS GPSAEQMCKTYSEFCSRHSKALKLY KELYARDKRFQQFIRKVTRPAVLKR HGVQECILLVTQRITKYPLLISRIL QHSHGIEEERQDLTTALGLVKELLS NVDEGIYQLEKGARLQEIYNRMDPR AQTPVPGKGPFGREELLRRKLIHDG CLLWKTATGRFKDVLVLLMTDVLVF LQEKDQKYIFPTLDKPSVVSLQNLI VRDIANQEKGMFLISAAPPEMYEVH TASRDDRSTWIRVIQQSVRTCPSRE DFPLIETEDEAYLRRIKMELQQKDR ALVELLREKVGLFAEMTHFQAEEDG GSGMALPTLPRGLFRSESLESPRGE RLLQDAIREVEGLKDLLVGPGVELL LTPREPALPLEPDSGGNTSPGVTAN GEARTFNGSIELCRADSDSSQRDRN GNQLRSPQEEALQRLVNLYGLLHGL QAAVAQQDTLMEARFPEGPERREKL CRANSRDGEAGRAGAAPVAPEKQAT ELALLQRQHALLQEELRRCRRLGEE RATEAGSLEARLRESEQARALLERE AEEARRQLAALGQTEPLPAEAPWAR RPVDPRRRSLPAGDALYLSFNPPQP SRGTDRLDLPVTTRSVHRNFEDRER QELGSPEERLQDSSDPDTGSEEEGS SRLSPPHSPRDFTRMQDIPEETESR DGEAVASES
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 [ Homo sapiens ]
Official Symbol : ARHGEF2
Synonyms : ARHGEF2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; rho/rac guanine nucleotide exchange factor (GEF) 2; rho guanine nucleotide exchange factor 2; GEF H1; KIAA0651; LFP40; P40; microtubule-regulated Rho-GEF; guanine nucleotide exchange factor H1; proliferating cell nucleolar antigen p40; Rho/Rac guanine nucleotide exchange factor 2; GEF; GEFH1; GEF-H1; FLJ45440; DKFZp547L106; DKFZp547P1516;
Gene ID : 9181
mRNA Refseq : NM_001162383
Protein Refseq : NP_001155855
MIM : 607560
UniProt ID : Q92974

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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What are the potential therapeutic implications of targeting ARHGEF2? 02/18/2023

Targeting ARHGEF2 or its downstream effectors could hold therapeutic potential for various diseases. Given its role in cancer metastasis, inhibiting ARHGEF2 could help prevent or reduce tumor cell invasion and migration. Modulating ARHGEF2 activity could also be beneficial in cardiovascular diseases by regulating blood vessel contraction and cardiac hypertrophy. Furthermore, targeting ARHGEF2 in neurological disorders might help regulate neuronal development and synaptic plasticity.

Are there any known interacting partners of ARHGEF2? 01/22/2021

ARHGEF2 can interact with multiple proteins to exert its functions. It has been reported to interact with and activate several Rho GTPases, including RhoA, RhoB, and RhoC. ARHGEF2 can also interact with other signaling molecules, such as focal adhesion kinase (FAK), paxillin, and Galpha12/13 proteins, to regulate cytoskeletal dynamics and cell adhesion.

Can ARHGEF2 interact with other proteins involved in cell signaling pathways? 06/05/2020

Yes, ARHGEF2 can interact with several other proteins involved in cell signaling pathways. It can interact with integrin-associated proteins like vinculin and talin, as well as adherens junction proteins such as E-cadherin, β-catenin, and α-catenin. These interactions modulate cell adhesion and cytoskeletal dynamics. Additionally, ARHGEF2 can interact with signaling molecules like G-protein-coupled receptors (GPCRs), growth factor receptors, and non-receptor tyrosine kinases, enabling crosstalk between different signaling pathways.

What are the potential downstream effectors or signaling pathways regulated by ARHGEF2? 11/10/2018

ARHGEF2 has been shown to activate RhoA, which in turn regulates a variety of downstream effectors and signaling pathways. This includes the Rho-associated protein kinase (ROCK) pathway, which controls actin-myosin contractility and cell shape changes, as well as the mDia and IRSp53 pathways involved in actin filament assembly. Additionally, ARHGEF2 can activate Rac1, which can activate JNK and p38 MAP kinase pathways to influence cell migration and invasion.

Are there any known genetic mutations or polymorphisms in the ARHGEF2 gene? 06/11/2018

Yes, mutations in the ARHGEF2 gene have been associated with different disorders. In particular, loss-of-function mutations in ARHGEF2 have been linked to intellectual disability and developmental delay. These mutations can lead to altered Rho GTPase signaling, affecting cellular processes involved in neural development and cognition. Additionally, variations in the ARHGEF2 gene have been found to be associated with hypertension susceptibility in certain populations.

Are there any ongoing research efforts focused on ARHGEF2? 05/29/2018

Yes, research on ARHGEF2 is ongoing. Scientists continue to investigate its role in various cellular processes and its involvement in different diseases. They are studying the mechanisms of ARHGEF2 activation, its interaction partners, and the downstream pathways it regulates. Additionally, efforts are being made to explore potential therapeutic strategies targeting ARHGEF2 for diseases such as cancer and neurological disorders.

What are the cellular processes and functions associated with ARHGEF2? 01/24/2018

ARHGEF2 is involved in multiple cellular processes, including actin cytoskeleton organization, cell adhesion, cell migration, cell proliferation, and cell polarity. It regulates these processes by activating Rho GTPases, which in turn control the organization of the actin cytoskeleton and the dynamics of cell shape changes. ARHGEF2 is essential for various physiological processes, such as development, tissue homeostasis, and wound healing, and its dysregulation is associated with pathological conditions like cancer and cardiovascular diseases.

Is ARHGEF2 associated with any diseases or pathological conditions? 01/25/2017

Yes, ARHGEF2 has been implicated in various diseases and pathological conditions. It has been found to be involved in cancer progression and metastasis by promoting cell migration, invasion, and epithelial-mesenchymal transition (EMT). ARHGEF2 has also been linked to cardiovascular diseases, such as hypertension and cardiac hypertrophy, as well as neuronal disorders, including epilepsy and intellectual disability.

Customer Reviews (8)

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Reviews
10/09/2021

    the manufacturer's commitment to delivering the ARHGEF2 protein in a timely manner is greatly appreciated.

    05/02/2021

      the ARHGEF2 protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

      01/04/2021

        Their prompt and knowledgeable assistance has the potential to solve any difficulties I may encounter during my experiments.

        09/02/2020

          The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.

          10/25/2019

            The cost-effectiveness of the ARHGEF2 protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.

            01/15/2019

              Another advantage of the ARHGEF2 protein is its reliability and consistency, ensuring robust and reproducible results.

              11/29/2018

                the manufacturer's support plays a crucial role in the successful implementation of trials involving the ARHGEF2 protein.

                10/26/2016

                  I am confident that my experimental needs will be met through their assistance, ensuring successful outcomes in my trials.

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