ARHGEF9 Protein, Cdc42 guanine nucleotide exchange factor (GEF) 9

ARHGEF9

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ARHGEF9

Official Full Name Cdc42 guanine nucleotide exchange factor (GEF) 9
Background The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Synonyms ARHGEF9; Cdc42 guanine nucleotide exchange factor (GEF) 9; PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN; rho guanine nucleotide exchange factor 9; PEM-2 homolog; hPEM-2 collybistin; rac/Cdc42 guanine nucleotide exchange factor 9;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF9-791H Recombinant Human ARHGEF9 protein, GST-tagged Wheat Germ GST
    Human ARHGEF9-8728HCL Recombinant Human ARHGEF9 293 Cell Lysate HEK293 N/A
    Mouse ARHGEF9-1908M Recombinant Mouse ARHGEF9 Protein Mammalian Cell His
    Rat ARHGEF9-774R Recombinant Rat ARHGEF9 Protein Mammalian Cell His

    ARHGEF9 involved in several pathways and played different roles in them. We selected most pathways ARHGEF9 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GABA A receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell death signalling via NRAGE, NRIF and NADE KALRNB; ARHGEF18; ARHGEF17; BCL2L11; ITGB3BP; ARHGAP4A; MCF2L; ARHGEF18A; AATF; CASP2
    G alpha (12/13) signalling events MCF2L; KALRNB; ARHGAP4; ARHGEF9; FGD2; GNA13; TRIO; GNA13B; TIAM2; NET1
    GABA A receptor activation ARHGEF9
    GABA receptor activation KCNJ9; KCNJ2A; KCNJ2; KCNJ12; GNB3A; GNGT2A; ARHGEF9; KCNJ4; GABRR2A; GNGT2B
    GPCR downstream signaling NMU; CHRM5; EDN2; PENKB; RAMP1; ADORA3; SSTR1; TRIO; CCR1; OR4D2
    Ion channel transport TTYH3; ATP13A1; TPCN1; UNC79; TRPC4APA; ATP13A5; TRPC4A; TRPC5; TSC22D3; TRDN
    Ligand-gated ion channel transport HTR3C; GLRBA; GABRR2A; ARHGEF9
    NRAGE signals death through JNK AKAP13; ARHGEF3; ARHGEF9; NET1; ARHGEF18; MCF2L; ARHGEF17; FGD2; ECT2; ARHGEF16

    ARHGEF9 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF9 itself. We selected most functions ARHGEF9 had, and list some proteins which have the same functions with ARHGEF9. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity FARP2; PREX1; ARHGEF19; ARHGEF7B; BCR; ARHGEF16; ARHGEF9B; FGD6; ARHGEF1; FGD5

    ARHGEF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF9.

    PLEKHA5

    Kusuhara, S; Fukushima, Y; et al. Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells. PLOS ONE 7:-(2012).
    Guo, F; Xing, Y; et al. GUANINE-NUCLEOTIDE EXCHANGE FACTOR H1 MEDIATES LIPOPOLYSACCHARIDE-INDUCED INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR alpha EXPRESSION IN ENDOTHELIAL CELLS VIA ACTIVATION OF NUCLEAR FACTOR kappa B. SHOCK 37:531-538(2012).

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