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ARPC2

  • Official Full Name

    actin related protein 2/3 complex, subunit 2, 34kDa

  • Overview

    This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
  • Synonyms

    ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2 (34 kD); actin-related protein 2/3 complex subunit 2; ARC34; p34 Arc; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; PRO2446; p34-Arc; PNAS-139;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Porcine
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Brain
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC2-7566H Recombinant Human ARPC2, His-tagged E.coli His 1-300aa
Human ARPC2-9883H Recombinant Human ARPC2, His-tagged E.coli His 1-300a.a.
Human ARPC2-850H Recombinant Human ARPC2, His-tagged E.coli His
Human ARPC2-846H Recombinant Human ARPC2 protein, GST-tagged Wheat Germ GST
Human ARPC2-8685HCL Recombinant Human ARPC2 293 Cell Lysate HEK293 N/A
Human ARPC2-1207H Recombinant Human ARPC2 protein, GST-tagged E.coli GST 1-300 aa
Human ARPC2-702H Recombinant Human ARPC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARPC2-1105HF Recombinant Full Length Human ARPC2 Protein, GST-tagged In Vitro Cell Free System GST 300 amino acids
Human ARPC2-151H Recombinant Human ARPC2 Protein, His-tagged Human Cells His
Human ARPC2-5196H Recombinant Human ARPC2 protein, GST-tagged E.coli GST 1-250aa
Mouse Arpc2-1725M Recombinant Mouse Arpc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Arpc2-3105R Recombinant Rat Arpc2, His-tagged E.Coli or Yeast His 300
Porcine ARPC2-01P Native Porcine ARPC2 Protein (Arp2/3 Protein Complex) Brain
Rhesus Macaque ARPC2-416R Recombinant Rhesus monkey ARPC2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ARPC2-245R Recombinant Rhesus Macaque ARPC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ARPC2-245R-B Recombinant Rhesus Macaque ARPC2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ARPC2-11974Z Recombinant Zebrafish ARPC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARPC2 involved in several pathways and played different roles in them. We selected most pathways ARPC2 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceDNM2;KCNQ2;ROCK2;SPTBN1;GNAI3;SRGAP3;MAPK1;KALRN;NRG3
B Cell Receptor Signaling PathwayLIME1;Cd79a, Cd79b;MAPK4;PPP3R2;PIK3AP1;MAP2K2;CD79A;GRB2;VAV1
Bacterial invasion of epithelial cellsCDH1;HCLS1;ARPC3;SEPT1;GAB1;CLTA;SEPT6;ELMO2;ELMO1
CDC42 signaling eventsACTR3;ACTR2;CFL1;CTNNA1;ARPC3;ARPC5;IQGAP3;PAK4;TNK2
Developmental BiologyKIF4;KCNQ2;TRPC3;CACNG2B;SEMA4D;MED15;DUSP9;COL6A2;ANK2B
EPH-Ephrin signalingEFNA3;ACTR2;ARPC5;AP2A2;CFL1;EFNB3;SDCBP;ARPC3;ACTR2B
EPHB-mediated forward signalingKALRN;EFNB2A;EFNB3;ARPC1B;ACTR2;EPHB4B;EPHB3A;ACTR2B;KALRNB
EndocytosisPDCD6IP;ARPC2;CAV3;CAPZA3;PIP5K1AB;SMAD2;CYTH4B;SNX4;SH3GL2

ARPC2 has several biochemical functions, for example, AP-1 adaptor complex binding, Arp2/3 complex binding, contributes_to actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC2 itself. We selected most functions ARPC2 had, and list some proteins which have the same functions with ARPC2. You can find most of the proteins on our site.

Function Related Protein
AP-1 adaptor complex bindingARPC2;AP1AR;RAB32;RAB38
Arp2/3 complex bindingWHAMM;SNX9;CORO1B;ARPC2;PICK1;GMFG;HAND2;GMFB
contributes_to actin filament bindingMYH10;ACTR2;ARPC3;ARPC2;ARPC5;ARPC4;MYH9;ARPC1B;ACTR3
kinesin bindingDISC1;KTN1;SNCA;JIP1;JAKMIP1;KIAA1279;KIFAP3;ACTB;PLEKHM2
protein bindingSSX1;TAF9B;USP8;TMEM59;ABLIM3;BMPR1B;MSH2;PCBD1;XRCC2
structural constituent of cytoskeletonSPTBN2;TUBG1;YEATS4;TUBA2;ADD3;VILL;TUBB2A;TUBB;TUBA4A

ARPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC2.

CORO1B; VCL; VCL; HLA-B; Wasf1; ACTR3B; TRAF6; q7ard3_yerpe; tdh; MYH9; IQGAP1; CAPZA2; Tpm1; Actb; ACTR2; PPP1CB

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What cellular processes rely on ARPC2 and the Arp2/3 complex? 11/02/2021

The Arp2/3 complex, including ARPC2, is essential for various cellular processes. It plays a critical role in cell migration and adhesion, enabling cells to move and change shape. The complex is also involved in endocytosis, phagocytosis, and vesicle trafficking, regulating membrane dynamics. Additionally, ARPC2 and the Arp2/3 complex contribute to cell division, neuronal development, and immune cell function.

How is the expression of ARPC2 regulated at the molecular level? 11/24/2020

The expression of ARPC2 can be regulated transcriptionally through the binding of specific transcription factors to the promoter region of the ARPC2 gene. Additionally, post-transcriptional mechanisms like microRNAs or RNA-binding proteins can also affect the stability or translation efficiency of ARPC2 mRNA. Furthermore, epigenetic modifications, such as DNA methylation or histone acetylation, can play a role in regulating ARPC2 gene expression.

Are there any known diseases or disorders associated with ARPC2 mutations? 10/14/2020

Mutations in the ARPC2 gene have been linked to a rare genetic disorder called Wiskott-Aldrich syndrome (WAS). WAS is characterized by immune system abnormalities, eczema, and a higher risk of developing certain types of cancer. Although mutations in the ARPC2 gene are relatively rare in WAS, they can disrupt the normal function of the Arp2/3 complex, leading to actin cytoskeleton defects.

Is the expression of the ARPC2 gene regulated during development? 10/07/2020

Yes, the expression of the ARPC2 gene can be regulated during development. Transcription factors specific to certain developmental stages or tissues can bind to the regulatory regions of the gene and control its expression. Additionally, epigenetic modifications may also influence the expression patterns of ARPC2 during development.

Are there any known inhibitors or activators of ARPC2? 11/26/2017

Currently, there are no specific inhibitors or activators targeting ARPC2 directly. However, various compounds and drugs that target the Arp2/3 complex or actin cytoskeleton dynamics in general can indirectly impact the function of ARPC2. These include small molecule inhibitors of actin polymerization and drugs that modulate actin-binding proteins involved in regulating ARPC2 activity.

Are there any interacting proteins or complexes that interact with ARPC2? 06/13/2017

ARPC2 interacts with several other proteins and complexes involved in actin cytoskeleton regulation. It forms a stable complex with other subunits (ARPC1-5) to constitute the Arp2/3 complex. This complex interacts with nucleation promoting factors (NPFs) such as WASP and WAVE, which facilitate actin filament branching. Furthermore, ARPC2 can also interact with actin-binding proteins and signaling molecules, leading to cytoskeletal rearrangements and cellular responses.

Customer Reviews (3)

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Reviews
01/23/2023

    Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.

    08/28/2018

      Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.

      10/30/2016

        Highly recommended!

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