arpc2
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  • Official Full Name
  • actin related protein 2/3 complex, subunit 2, 34kDa
  • Background
  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
  • Synonyms
  • ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2 (34 kD); actin-related protein 2/3 complex subunit 2; ARC34; p34 Arc; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; PRO2446; p34-Arc; PNAS-139
Cat.#:ARPC2-850HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARPC2, His-tagged
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Cat.#:ARPC2-7566HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARPC2, His-tagged
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Cat.#:ARPC2-846HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARPC2 protein, GST-tagged
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Cat.#:ARPC2-9883HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARPC2, His-tagged
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Cat.#:Arpc2-3105RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Arpc2, His-tagged
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Cat.#:ARPC2-416RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ARPC2 Protein, His-tagged
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Cat.#:ARPC2-11974ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARPC2
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Cat.#:ARPC2-8685HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARPC2 293 Cell Lysate
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Involved Pathway

ARPC2 involved in several pathways and played different roles in them. We selected most pathways ARPC2 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
TRPC3; ACTR2; SEMA3D; GNAI1; SLIT2; NTNG1; PEBP1; PAK4; PPP3CB; CLTA
B Cell Receptor Signaling Pathway
PTPN18; PDK2B; ARPC1B; Cd79a, Cd79b; PPP3R1; PILRB; LIME1; INPP5D; ARPC3; PDPK1A
Bacterial invasion of epithelial cells
DNM3; PIK3R5; MAD2L2; RHOG; SHC2; CLTA; CDH1; CAV3; CLTB; WAS
CDC42 signaling events
ARPC5; PAK4; ACTR2; CFL1; IQGAP3; CDC42BPA; EPS8; CTNNA1; ACTR3; ARPC2
Developmental Biology
NRG2A; ARPC1A; MED18; CACNG2B; CLTA; ARPC2; ARPC3; MED20; RND1L; DNM1
EPH-Ephrin signaling
ACTR3; SHB; CLTB; MYL12B; EFNA5; AP2S1; EPHA2; EPHA4A; ARHGEF28; EFNA1B
EPHB-mediated forward signaling
EPHB4A; CFL1; EFNB2; ARPC4; ACTR3; ITSN1; EFNB1; ARPC3; ARHGEF28; ARPC1A
Endocytosis
BIN1B; HSP70L; PLD1; GRK4; ARFGEF1; ADRBK2; LDLRAP1A; CDC42L; SNX6; ARPC5B

Protein Function

ARPC2 has several biochemical functions, for example, AP-1 adaptor complex binding, Arp2/3 complex binding, contributes_to actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC2 itself. We selected most functions ARPC2 had, and list some proteins which have the same functions with ARPC2. You can find most of the proteins on our site.
Function
Related Protein
Function AP-1 adaptor complex binding
Related Protein AP1AR; ARPC2; RAB38; RAB32
Function Arp2/3 complex binding
Related Protein ARPC2; GMFG; PICK1; WHAMM; HAND2; CORO1B; SNX9; GMFB
Function contributes_to actin filament binding
Related Protein MYH9; ARPC2; MYH10; ARPC1B; ARPC3; ARPC5; ACTR3; ACTR2; ARPC4
Function kinesin binding
Related Protein SPAG9A; FAM83D; ARPC2; CLSTN1; KTN1; AP1G1; IFT88; DISC1; KIF1B; PIFO
Function protein binding
Related Protein CD44; INTS10; IGF2R; ARHGAP9; SPANXD; SMAD1; KDM4A; C9orf116; S100A14; FOXH1
Function structural constituent of cytoskeleton
Related Protein ANK1; DSP; TUBA2; BKJ; NEFM; TUBA1L2; EPB41L3; NGS; ARPC4; ADD3

Interacting Protein

ARPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC2.
CORO1B; VCL; VCL; HLA-B; Wasf1; ACTR3B; TRAF6; q7ard3_yerpe; tdh; MYH9; IQGAP1; CAPZA2; Tpm1; Actb; ACTR2; PPP1CB