ARPC2
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Official Full Name
actin related protein 2/3 complex, subunit 2, 34kDa
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Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. -
Synonyms
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2 (34 kD); actin-related protein 2/3 complex subunit 2; ARC34; p34 Arc; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; PRO2446; p34-Arc; PNAS-139;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Porcine
- Rat
- Rhesus Macaque
- Zebrafish
- Brain
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ARPC2 involved in several pathways and played different roles in them. We selected most pathways ARPC2 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | DNM2;KCNQ2;ROCK2;SPTBN1;GNAI3;SRGAP3;MAPK1;KALRN;NRG3 |
B Cell Receptor Signaling Pathway | LIME1;Cd79a, Cd79b;MAPK4;PPP3R2;PIK3AP1;MAP2K2;CD79A;GRB2;VAV1 |
Bacterial invasion of epithelial cells | CDH1;HCLS1;ARPC3;SEPT1;GAB1;CLTA;SEPT6;ELMO2;ELMO1 |
CDC42 signaling events | ACTR3;ACTR2;CFL1;CTNNA1;ARPC3;ARPC5;IQGAP3;PAK4;TNK2 |
Developmental Biology | KIF4;KCNQ2;TRPC3;CACNG2B;SEMA4D;MED15;DUSP9;COL6A2;ANK2B |
EPH-Ephrin signaling | EFNA3;ACTR2;ARPC5;AP2A2;CFL1;EFNB3;SDCBP;ARPC3;ACTR2B |
EPHB-mediated forward signaling | KALRN;EFNB2A;EFNB3;ARPC1B;ACTR2;EPHB4B;EPHB3A;ACTR2B;KALRNB |
Endocytosis | PDCD6IP;ARPC2;CAV3;CAPZA3;PIP5K1AB;SMAD2;CYTH4B;SNX4;SH3GL2 |
ARPC2 has several biochemical functions, for example, AP-1 adaptor complex binding, Arp2/3 complex binding, contributes_to actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC2 itself. We selected most functions ARPC2 had, and list some proteins which have the same functions with ARPC2. You can find most of the proteins on our site.
Function | Related Protein |
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AP-1 adaptor complex binding | ARPC2;AP1AR;RAB32;RAB38 |
Arp2/3 complex binding | WHAMM;SNX9;CORO1B;ARPC2;PICK1;GMFG;HAND2;GMFB |
contributes_to actin filament binding | MYH10;ACTR2;ARPC3;ARPC2;ARPC5;ARPC4;MYH9;ARPC1B;ACTR3 |
kinesin binding | DISC1;KTN1;SNCA;JIP1;JAKMIP1;KIAA1279;KIFAP3;ACTB;PLEKHM2 |
protein binding | SSX1;TAF9B;USP8;TMEM59;ABLIM3;BMPR1B;MSH2;PCBD1;XRCC2 |
structural constituent of cytoskeleton | SPTBN2;TUBG1;YEATS4;TUBA2;ADD3;VILL;TUBB2A;TUBB;TUBA4A |
ARPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC2.
CORO1B; VCL; VCL; HLA-B; Wasf1; ACTR3B; TRAF6; q7ard3_yerpe; tdh; MYH9; IQGAP1; CAPZA2; Tpm1; Actb; ACTR2; PPP1CB
- Q&As
- Reviews
Q&As (6)
Ask a questionThe Arp2/3 complex, including ARPC2, is essential for various cellular processes. It plays a critical role in cell migration and adhesion, enabling cells to move and change shape. The complex is also involved in endocytosis, phagocytosis, and vesicle trafficking, regulating membrane dynamics. Additionally, ARPC2 and the Arp2/3 complex contribute to cell division, neuronal development, and immune cell function.
The expression of ARPC2 can be regulated transcriptionally through the binding of specific transcription factors to the promoter region of the ARPC2 gene. Additionally, post-transcriptional mechanisms like microRNAs or RNA-binding proteins can also affect the stability or translation efficiency of ARPC2 mRNA. Furthermore, epigenetic modifications, such as DNA methylation or histone acetylation, can play a role in regulating ARPC2 gene expression.
Mutations in the ARPC2 gene have been linked to a rare genetic disorder called Wiskott-Aldrich syndrome (WAS). WAS is characterized by immune system abnormalities, eczema, and a higher risk of developing certain types of cancer. Although mutations in the ARPC2 gene are relatively rare in WAS, they can disrupt the normal function of the Arp2/3 complex, leading to actin cytoskeleton defects.
Yes, the expression of the ARPC2 gene can be regulated during development. Transcription factors specific to certain developmental stages or tissues can bind to the regulatory regions of the gene and control its expression. Additionally, epigenetic modifications may also influence the expression patterns of ARPC2 during development.
Currently, there are no specific inhibitors or activators targeting ARPC2 directly. However, various compounds and drugs that target the Arp2/3 complex or actin cytoskeleton dynamics in general can indirectly impact the function of ARPC2. These include small molecule inhibitors of actin polymerization and drugs that modulate actin-binding proteins involved in regulating ARPC2 activity.
ARPC2 interacts with several other proteins and complexes involved in actin cytoskeleton regulation. It forms a stable complex with other subunits (ARPC1-5) to constitute the Arp2/3 complex. This complex interacts with nucleation promoting factors (NPFs) such as WASP and WAVE, which facilitate actin filament branching. Furthermore, ARPC2 can also interact with actin-binding proteins and signaling molecules, leading to cytoskeletal rearrangements and cellular responses.
Customer Reviews (3)
Write a reviewIts remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.
Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.
Highly recommended!
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